PROGRAM PLANNING COMMITTEE Jim Wells, Ph.D. (Chair) Oscar Millet, Ph.D Mark A. Lemmon, Ph.D. Professor and Chair, Dept of Structural Biology Unit Professor and Chair, Dept of Pharmaceutical Chemistry CIC bioGUNE Biochemistry and Biophysics University of California, San University of Pennsylvania Francisco Perelman School of Medicine Miquel Pons, Ph.D. Gary Pielak, Ph.D. Professor, Dept of Organic Chemistry Distinguished Term Professor of Chemistry, Universitat de Barcelona Biochemistry and Biophysics University of North Carolina, Chapel Hill THANK YOU TABLE OF CONTENTS Symposium Overview .................................................................................................... 3 Executive Council & Leadership ................................................................................. 4 Committees ...................................................................................................................... 5 Protein Society Awards ................................................................................................. 6 Call for 2015 Nominations ............................................................................................... 8 Hotel Floorplan ............................................................................................................... 9 General Information .................................................................................................... 10 Travel Awards ................................................................................................................ 12 Donor Acknowledgements ......................................................................................... 13 Daily Program ............................................................................................................... 14 Day 1 ................................................................................................................................14 Day 2................................................................................................................................ 17 Day 3 ................................................................................................................................21 Day 4............................................................................................................................... 24 Poster Sessions ............................................................................................................. 26 Exhibitors ....................................................................................................................... 47 Exhibitor Workshops .................................................................................................. 54 Speaker Abstracts ......................................................................................................... 55 Poster Abstracts ............................................................................................................ 71 Author Index ............................................................................................................... 274 THANK YOU THE 2014 PROGRAM PLANNING COMMITTEE Todd O. Yeates, Ph.D. Jennifer R. Potts, Ph.D. Professor, Department of Chemistry and Professor and Chair of Molecular Biochemistry Biophysics University of California, Los Angeles Department of Biology The University of York Tarun Kapoor, Ph.D. Pels Family Professor Laboratory of Chemistry and Cell Biology The Rockefeller University CORPORATE SUPPORT The Protein Society is grateful to the following corporate partnerns for supporting the 28th Annual Symposium & The Protein Society: 28TH ANNUAL SYMPOSIUM SPONSORS Proteins in Disease & Therapeutics Research Session Best Poster Competition Complimentary Tote Bags 2014 CORPORATE MEMBERS Gold Level Bronze Level SYMPOSIUM OVERVIEW DAY 1 DAY 2 DAY 3 DAY 4 SUNDAY JULY 27TH MONDAY JULY 28TH TUESDAY JULY 29TH WEDNESDAY JULY 30TH 7:00 AM Members Business Meeting/New Member Welcome Breakfast (75 min) - Marina Room 8:30 AM Opening Plenary Session Protein Proteins in Protein Proteins In Closing Plenary Session & & 2014 Hans Neurath Evolution Disease & Engineering Dynamic & 2014 Stein & Moore Award Winner Talk Grand HAll C Thera- & Synthetic Driven Award Winner Talk Grand Hall C & D peutics Biology Processes Grand Hall C & D Grand HAll D Grand HAll C Grand HAll D 9:40 AM Translation Bacterial Protein Membrane & Folding Interactions Degra- Proteins & Grand HAll C Grand Hall D dation Receptors Grand HAll C Grand HAll D 11:30 AM 11:30 -Exhibits & Poster Displays LUNCH (2 hrs) - Grand Hall A & B (2 hrs) Exhibitor Workshop Exhibitor Workshop Exhibitor Workshop GE Healthcare NanoTemper GE Healthcare EW I-47 NEW Amersham™ 600 Technologies EW III-49 Multimodal Imager series (CCD-based Some like it hot: Determination chromatography: A new camera systems) of Biomolecular Interactions generation of high selectivity (1 hr) - Gaslamp A using MicroScale media for challenging Thermophoresis purifications (1 hr) - Gaslamp A (1 hr) - Gaslamp A All Lunch Workshops from Noon - 1PM Workshop: Undergrad Educator’s Workshop: Workshop: Workshop: How to Research Luncheon How to Write WikiPedia for How to Improve Your Session (1 hr) an Effective Protein Navigate End of Program Writing (1 hr) Bankers Hill Paper Scientists Your Career (1 hr) Bankers Hill (1 hr) (1 hr) (1 hr) Gaslamp C & D Gaslamp C & D Bankers Hill Gaslamp C & D 1:30 PM Frontier Proteins in Chemical Cellular Plenary Awards Session High- Altered Biology & Structures 1:30 PM - 5:50 PM Throughput States Enzymology Grand HAll D Techniques Grand HAll D Grand HAll C Grand Hall C & D Grand HAll C 4:30 PM Exhibits & Poster Displays (2 hrs) - Grand Hall A & B 7:00 PM Networking Dinners (3hrs) Members Reception - Locations Vary (3hrs) - Please View the 8:00 PM Education & Mentoring Program Addendum for Committees’ Mixer Location (3 hrs) Kin Spa Pool Deck, 3rd Floor Following the Symposium, please take a few moments to share your feedback when you receive the Attendee Survey 3 EXECUTIVE COUNCIL & LEADERSHIP President Secretary/Treasurer Past-President James Bowie, University of Jacquelyn Fetrow, University of Lynne Regan, Yale University California, Los Angeles Richmond Lars Baltzer, Uppsala Paula Booth, University Charles Brooks, III, Johannes Buchner, University of Bristol University of Michigan Technische Universität München Zengyi Chang, Peking Stewart Fisher, SL Amy Keating, Jacqui Matthews, University Fisher Consulting Massachusetts Institute University of Sydney of Technology Haruki Nakamura, Andreas Plückthun, Catherine Royer, Michael Summers, Osaka University Universität Zurich Rensselaer Polytechnic University of Maryland, Institute Baltimore County Sarah Teichmann, Brian Matthews (ex officio), Jody McGinness (ex officio), EMBL-EBI/Wellcome Trust Editor in Chief, University of Executive Director, The Protein Sanger Institute Oregon Society 4 NOMINATING COMMITTEE ABSTRACT REVIEW COMMITTEE Mary Munson, University of Massachusetts John Osterhout, Angelo State University (Chair) Medical School (Chair) Cory L Brooks, California State University - Fresno Judith Frydman, Stanford University Christopher Bystroff, Rensselaer Polytechnic Matthais Mann, Max-Planck-Institut für Biochemie Institute Thomas Magliery, The Ohio State University Paola Di Lello, Genentech, Inc. Andrew Miranker, Yale University John J. Dwyer, Ferring Research Institute Mary Munson, University of Massachusetts Francisco J. Enguita, University of Lisbon Medical School Angelo M. Figueiredo, University of East Anglia Brenda Schulman, St. Jude Children's Research Hospital Azucena G. Horta, Universidad Autonoma de Nuevo Leon Wei Yang, LMB, NIDDK, NIH Mary Konkle, Eastern Illinois Univerrsity PUBLICATIONS COMMITTEE Suresh Kumar, University of Arkansas Amy Keating, Massachusetts Institute of Patricia Ann Mabrouk, Northeastern University Technology (Chair) Todd Naumann, USDA-ARS-NCAUR James Bowie, University of California - Los Angeles Matthew Torres, Georgia Institute of Technology Arthur Palmer, III, Columbia University Sudha Veeraraghavan, University of Maryland Lynne Regan, Yale University School of Pharmacy Jacquelyn Fetrow, University of Richmond Bo Zhang, DuPont Industrial Biosciences Zhiwen Zhang, Santa Clara University Brian Matthews, University of Oregon MENTORING COMMITTEE Andrew Vendel, Eli Lilly and Company (Chair) Judith Klein-Seetharaman, University of Pittsburgh Blake Hill, Medical College of Wisconsin School of Medicine Kevin Lumb, Merck & Company Giovanna Ghirlanda, Arizona State University Matthew Cordes, University of Arizona Janel McLean, Vanderbilt University Medical Center Patricia Jennings, University of California, San Diego Carly Huitema, SIAF institute Olve Peersen, Colorado State University Eric Sundberg, University of Maryland School of Medicine Stephen Fuchs, Tufts University EDUCATION COMMITTEE Ellis Bell, University of Richmond (Chair) John Osterhout, Angelo State University Margaret Cheung, University of Houston Jane Richardson, Duke University Matthew Gage, Northern Arizona University Srebrenka Robic, Agnes Scott College Lisa Gentile, University of Richmond Michael Summers, University of Maryland - Peter Kahn, Rutgers University Baltimore County/HHMI Betsy Komives, University of California - San Diego Frieda Texter, Albright College Mary Konkle, Eastern Illinois University Jeff Watson, Gonzaga University 5 2014 PROTEIN SOCIETY AWARDS The Carl Brändén Award, sponsored by Rigaku Corporation, is given to an outstanding protein scientist