ISSN 2278- 4136 ZDB-Number: 2668735-5 IC Journal No: 8192 Volume 1 Issue 6 Online Available at www.phytojournal.com Journal of Pharmacognosy and Phytochemistry Phytochemistry of Medicinal Plants Mamta Saxena*1, Jyoti Saxena1, Rajeev Nema2, Dharmendra Singh2 and Abhishek Gupta2 1. Sarojini Naidu Government Girls Post Graduate (Autonomous) College, Shivaji Nagar, Bhopal - 462016 (M.P.), India. [E-mail: [email protected]] 2. Center for Microbiology & Bio-Technology Research and Training, Bhopal, India Medicinal plants are a rich source of bioactive phytochemicals or bionutrients. Studies carried out during the past 2– 3 decades have shown that these phytochemicals have an important role in preventing chronic diseases like cancer, diabetes and coronary heart disease. The major classes of phytochemicals with disease-preventing functions are dietary fibre, antioxidants, anticancer, detoxifying agents, immunity-potentiating agents and neuropharmacological agents. Each class of these functional agents consists of a wide range of chemicals with differing potency. Some of these phytochemicals have more than one function. There is, however, much scope for further systematic research in screening Indian medicinal plants for these phytochemicals and assessing their potential in protecting against different types of diseases Keyword: Phytochemicals, Alkaloids, Terpenoids, Flavonoids, Saponins, Tannins and Phenolics. 1. Introduction In wide-ranging dietary phytochemicals are found Phytochemicals (from the Greek word phyto, in fruits, vegetables, legumes, whole grains, nuts, meaning plant) are biologically active, naturally seeds, fungi, herbs and spices[3]. Broccoli, occurring chemical compounds found in plants, cabbage, carrots, onions, garlic, whole wheat which provide health benefits for humans further bread, tomatoes, grapes, cherries, strawberries, than those attributed to macronutrients and raspberries, beans, legumes, and soy foods are micronutrients[1]. They protect plants from common sources[6]. Phytochemicals accumulate disease and damage and contribute to the plant’s in different parts of the plants, such as in the color, aroma and flavor. In general, the plant roots, stems, leaves, flowers, fruits or seeds7. chemicals that protect plant cells from Many phytochemicals, particularly the pigment environmental hazards such as pollution, stress, molecules, are often concentrated in the outer drought, UV exposure and pathogenic attack are layers of the various plant tissues. Levels vary called as phytochemicals[2,3]. Recently, it is from plant to plant depending upon the variety, clearly known that they have roles in the processing, cooking and growing conditions[8]. protection of human health, when their dietary Phytochemicals are also available in intake is significant. More than 4,000 supplementary forms, but evidence is lacking that phytochemicals have been cataloged[4] and are they provide the same health benefits as dietary classified by protective function, physical phytochemicals[4]. characteristics and chemical characteristics[5] and About 150 phytochemicals have been studied in These compounds are known as secondary detail[4]. plant metabolites and have biological properties Vol. 1 No. 6 2013 www.phytojournal.com Page | 168 Journal of Pharmacognosy and Phytochemistry such as antioxidant activity, antimicrobial effect, modulation of detoxification enzymes, 2. The Journey of Medicinal Plant Research stimulation of the immune system, decrease of An assessment of the previous trends and impact platelet aggregation and modulation of hormone of research into the phytochemistry on medicinal metabolism and anticancer property. There are plants of the world is quite desirable before more than thousand known and many unknown considering recent trends. After centuries of phytochemicals. It is well-known that plants empirical use of herbal preparation, the first produce these chemicals to protect themselves, isolation of active principles alkaloids such as but recent researches demonstrate that many morphine, strychnine, quinine etc. in the early phytochemicals can also protect human against 19th century marked a new era in the use of diseases[9]. medicinal plants and the beginning of modern medicinal plants research. Emphasis shifted away from plant derived drugs with the tremendous development of synthetic pharmaceutical chemistry and microbial fermentation after 1945. Plant metabolites were mainly investigated from a phytochemical and chemotaxonomic viewpoint during this period. Over the last decade, however, interest in drugs of plant and probably animal origin has grown steadily[10]. Utilization of medicinal plants has almost doubled in Western Europe during that period. Ecological awareness, the efficacy of a good number of phytopharmaceutical preparations, such as ginkgo, garlic or valerian and increased interest of major pharmaceutical companies in higher medicinal plants as sources for new lead structures has been the main reasons for this renewal of interest. With the development of chemical science and pharmacognosy physicians began to extract chemical products from medicinal plants. A few examples of the products extracted from medicinal plants are - in 1920, quinine was isolated from Cinchona by the Fig.1: Phytochemistry of medicinal plants. French pharmacist, Peletier & Caventou. In the mid-nineteenth century, a German chemist, Phytochemicals are not essential nutrients and are Hoffmann obtained Aspirin from the bark of the not required by the human body for sustaining willow. With the active principles in medicinal life, but have important properties to prevent or to plants identified and isolated, plant-based fight some common diseases. Many of these prescriptions began to be substituted more and benefits suggest a possible role for more with pure substances, which were more phytochemicals in the prevention and treatment powerful and easier to prescribe and administer11. of disease, Because of this property; many Phytomedicine almost went into extinction during researchers have been performed to reveal the the first half of the 21st century due to the use of beneficial health effects of phytochemicals. The the ‘more powerful and potent synthetic drug’. purpose of the present review is to provide an However, because of the numerous side effects of overview of the extremely diverse these drugs, the value of medicinal plants is being phytochemicals presents in medicinal plants. rediscovered as some of them have proved to be Vol. 1 No. 6 2013 www.phytojournal.com Page | 169 Journal of Pharmacognosy and Phytochemistry as effective as synthetic medicines with fewer or normalizing blood pressure and clotting, and no side effects and contraindications. It has been improving arterial elasticity[3,13]. Phytochemicals proved that although the effects of natural may detoxify substances that cause cancer. They remedies may seem slower, the results are appear to neutralize free radicals, inhibit enzymes sometimes better on the long run especially in that activate carcinogens, and activate enzymes chronic diseases[12]. that detoxify carcinogens. For example, according to data summarized by Meagher and 3. Biological Activities of Phytochemicals Thomson, genistein prevents the formation of The phytochemicals present in plants are new capillaries that are needed for tumor growth responsible for preventing disease and promoting and metastasis[5]. The physiologic properties of health have been studied extensively to establish relatively few phytochemicals are well their efficacy and to understand the underlying understood and more many research has focused mechanism of their action. Such studies have on their possible role in preventing or treating included identification and isolation of the cancer and heart disease[3]. Phytochemicals have chemical components, establishment of their also been promoted for the prevention and biological potency both by in vitro and in vivo treatment of diabetes, high blood pressure, and studies in experimental animals and through macular degeneration[4]. While phytochemicals epidemiological and clinical-case control studies are classified by function, an individual in man. Study findings suggest that compound may have more than one biological phytochemicals may reduce the risk of coronary function serving as both an antioxidant and heart disease by preventing the oxidation of low- antibacterial agent13. Bioactive and Disease- density lipoprotein (LDL) cholesterol, reducing preventing phytochemicals present in plant are the synthesis or absorption of cholesterol, shown in Table 1. Table 1. Bioactive Phytochemicals In Medicinal Plants. Classification Main groups of compounds Biological function NSA Cellulose, hemicellulose, gums, Water holding capacity, delay in nutrient (Non-starch poly- mucilages, pectins, lignins absorption, binding toxins and bile acids saccharides.) Antibacterial & Terpenoids, alkaloids, phenolics Inhibitors of micro-organisms, reduce the risk Antifungal of fungal infection Antioxidants Polyphenolic compounds, flavonoids, Oxygen free radical quenching, inhibition of carotenoids, tocopherols, ascorbic acid lipid peroxidation Anticancer Carotenoids, polyphenols, curcumine, Inhibitors of tumor, inhibited development of Flavonoids lung cancer, anti-metastatic activity Detoxifying Reductive acids, tocopherols, phenols, Inhibitors of procarcinogen activation, Agents indoles, aromatic isothiocyanates, coumarins, inducers of drug binding of carcinogens, flavones, carotenoids, retinoids,