Table of Contents School of Medicine .................................... 2 Anesthesiology and Perioperative Medicine ...................................................................... 15 Department of Anatomy ............................ 16 Department of Biochemistry .................... 21 Department of Bioethics ........................... 30 Department of Genetics ............................ 39 Department of Neurosciences .................. 45 Department of Nutrition ............................ 48 Department of Pathology .......................... 56 Department of Pharmacology .................. 64 Department of Physiology and Biophysics ...................................................................... 71 Doctor of Medicine (MD) ........................... 77 Dual Degree Programs .............................. 89 Environmental Health Sciences ............... 95 Epidemiology and Biostatistics ............... 97 General Medical Sciences ...................... 116 Graduate Programs in the Biomedical Sciences ................................................... 131 Molecular Biology and Microbiology ..... 133 Molecular Medicine Program .................. 139 School of Medicine Faculty .................... 142 Index ....................................................... 233 2 School of Medicine School of Medicine The mission of the Case Western Reserve University School of Medicine • Earl W. Sutherland Jr., MD, who had been professor and director (http://casemed.case.edu) is to advance the health of humankind through of pharmacology from 1953 to 1963, won the 1971 Nobel Prize in the four interrelated components of Education, Research, Clinical Care Physiology or Medicine for establishing the identity and importance and Public Service. of cyclic adenosine monophosphate (AMP) in the regulation of cell metabolism. The School of Medicine provides two tracks leading to the MD degree: the longstanding School of Medicine program, also called the University • Paul Berg, PhD, who earned his biochemistry degree at the university track, and the Cleveland Clinic Lerner College of Medicine at Case in 1952, received the 1980 Nobel Prize in Chemistry for pioneering Western Reserve University, also known as the College track, which research in recombinant DNA technology. first admitted students in 2004. The School boasts a longstanding • H. Jack Geiger, MD, a 1958 alumnus of the medical school, is Medical Scientist Training Program, or MSTP, and, through the School of a founding member and past president of Physicians for Social Graduate Studies, programs resulting in PhD and MS degrees, as well as Responsibility, which shared the 1985 Nobel Peace Prize as part certificates in disciplines led by faculty in the School of Medicine. of International Physicians for the Prevention of Nuclear War, and Physicians for Human Rights (PHR), which shared the 1997 Nobel As a research institution, the School of Medicine has a tradition of Peace Prize as part of the International Campaign to Ban Landmines. national leadership. The School of Medicine consistently ranks in the top tier of the nation’s medical schools for federal research funding from • George H. Hitchings, PhD, who had been a biochemistry instructor the National Institutes of Health, and is proud of its Clinical Translational from 1939 to 1942, shared the 1988 Nobel Prize in Physiology or Service Award in partnership with its affiliates. In fiscal year 2010, the Medicine for research leading to the development of drugs to treat School earned more than $340 million in grants from the NIH including leukemia, organ transplant rejection, gout, the herpes virus and AIDS- grants through the affiliated Cleveland Clinic Lerner College of Medicine. related bacterial and pulmonary infections. Faculty and trainee research is routinely reported in the nation’s top • Alfred G. Gilman, MD, PhD, a 1969 graduate of the medical school, journals, leading to biomedical discoveries and improved health. shared the 1994 Nobel Prize for Physiology or Medicine for identifying the role of G proteins in cell communication. The School of Medicine engages the community in public service in • Ferid Murad, MD, PhD, a 1965 graduate of the medical school, many ways. The School of Medicine’s commitment links researchers shared the 1998 Nobel Prize in Physiology or Medicine for discoveries and medical students to the community. The school’s faculty provide 90 concerning nitric oxide as a signaling molecule in the cardiovascular percent of the indigent health care in Cuyahoga County and a majority system. of the care for indigent patients in Ohio. A major economic influence on the northern Ohio area, the School of Medicine and its affiliated • Paul C. Lauterbur, PhD, a 1951 graduate of the engineering school hospitals are among the largest employers of personnel in the area and and a visiting professor of radiology at Case in 1993, shared the further stimulate the economy by providing concepts for technology 2003 Nobel Prize in Physiology or Medicine for pioneering work in the transfer to the business sector. On the international level, the School of development of magnetic resonance imaging. Medicine has a global health and diseases program focusing on AIDS, • Peter C. Agre, MD, who completed a fellowship in hematology at Case tuberculosis, malaria and other diseases that directly threaten world while a medical student at Johns Hopkins, shared the 2003 Nobel health. Prize in Chemistry for discoveries that have clarified how salts and water are transported out of and into the cells of the body, leading to a The school is very proud of the contributions made by its educators better understanding of many diseases of the kidneys, heart, muscles and graduates but doesn’t rest on its laurels. The curriculum constantly and nervous system. responds to the latest findings in education and medicine and sets the pace for other schools with input from gifted and committed scholars. Two other distinguished alumni have served as U.S. surgeon general: At least eleven Nobel Prize holders have ties to the School of Medicine: Jesse Steinfeld, MD, a 1949 graduate, was surgeon general from 1969 to 1973, and David Satcher, MD, PhD, who graduated in 1970 and was • John J.R. Macleod, MB, ChB, DPH, physiology professor at Case surgeon general from 1998 to 2002. from 1903 to 1918, shared the 1923 Nobel Prize in Physiology or Medicine for the discovery of insulin. Dr. Macleod completed much of Dr. Satcher also served as director of the Centers for Disease Control his groundwork on diabetes in Cleveland. and Prevention from 1993 to 1998, and another medical school graduate, Julie Gerberding, MD, MPH, followed in his footsteps, in 2002 becoming • Corneille J.F. Heymans, MD, who was a visiting scientist in the the first woman to be named CDC director. Department of Physiology in 1927 and 1928, received the Nobel Prize in Physiology or Medicine in 1938 for work on carotid sinus reflexes. History • Frederick C. Robbins, MD, shared the 1954 Nobel Prize in Physiology Since its founding in 1843, the Case Western Reserve University School or Medicine for his work on the polio virus, which led to the of Medicine has been an innovator in medical education and a leader in development of polio vaccines. He received the award two years after pioneering research. Beginning as the Medical Department of Western joining the medical school. Dr. Robbins was active at the school until Reserve College (and popularly known then as the Cleveland Medical his death in 2003, at which time he held the titles of medical school College), the school moved into its first permanent home, in downtown dean emeritus, University Professor emeritus, and emeritus director of Cleveland, in 1846. In 1915, a 20-acre site was secured for a medical the Center for Adolescent Health. center in University Circle, the current home of Case Western Reserve University, its School of Medicine, and two of the school’s affiliated hospitals, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center. University Case Western Reserve University 3 Circle also is home to many of the country’s outstanding cultural and Hospitals of Cleveland dedicated the new, eight-floor Iris S. and Bert L. educational institutions. Wolstein Research Building, adding 320,000 square feet of space for up to 700 researchers. The school was one of the first medical schools in the country to employ instructors devoted to full-time teaching and research. Six of the first seven women to receive medical degrees from accredited American Affiliated Hospitals medical schools graduated from Western Reserve College (as it was called then) between 1850 and 1856. University Hospitals (http:// Already a leading educational institution for more than a century, in 1952 www.uhhospitals.org) the School of Medicine initiated the most advanced medical curriculum in University Hospitals serves the needs of patients through an integrated the country, pioneering integrated education, a focus on organ systems network of hospitals, outpatient centers and primary care physicians. and team teaching in the preclinical curriculum. This curriculum instituted At the core of the health system is University Hospitals Case Medical a pass/fail grading system for the first two years of medical school Center. The primary affiliate of Case Western Reserve University School to promote cooperation among students instead of competitiveness, of Medicine, University Hospitals Case Medical Center is home