Chicago | October 17-21 Sunday Scienti ic Session Listings 96–268 Information at a Glance Important Phone Numbers Annual Meeting Headquarters Office Mercy Hospital Key to Poster Floor by Themes Logistics and Programming 2525 S Michigan Avenue The poster floor begins with Theme A and ends Logistics Chicago, IL 60616 with Theme H. Refer to the poster floor map at McCormick Place: Hall A, (312) 791‑6700 (312) 567‑2000 the end of this booklet. Programming Physicians Immediate Care Theme McCormick Place: Hall A, (312) 791‑6705 811 S. State Street A Development Chicago, IL 60605 B Neural Excitability, Synapses, and Glia: Volunteer Leadership Lounge (312) 566‑9510 Cellular Mechanisms McCormick Place: S505A, (312) 791‑6735 Walgreens Pharmacy C Disorders of the Nervous System General Information Booths (closest to McCormick Place) D Sensory and Motor Systems McCormick Place: 3405 S. Martin Luther King Drive E Integrative Systems: Neuroendocrinology, Gate 3 Lobby, (312) 791‑6724 Chicago, IL 60616 Neuroimmunology and Homeostatic Challenge Hall A (312) 791‑6725 (312) 326‑4064 F Cognition and Behavior Press Offices Venues G Novel Methods and Technology Development Press Room McCormick Place H History, Teaching, Public Awareness, and McCormick Place: Room S501ABC 2301 S. Martin Luther King Drive Societal Impacts in Neuroscience (312) 791‑6730 Chicago, IL 60616 Exhibit Management Fairmont Chicago, Millennium Park Hotel Note: Theme H Posters will be located in Hall A McCormick Place: Hall A, (312) 791‑6740 200 N. Columbus Drive beginning at 1 p.m. on Saturday, Oct. 17, and will Chicago, IL 60601 remain posted until 5 p.m., Sunday, Oct. 18. First Aid and Hospital Numbers (312) 565‑8000 First Aid Station McCormick Place: Level 2.5S, (312) 791‑6060 Hyatt Regency Chicago Downtown Hotel (not connected to McCormick Place) 151 E. Wacker Drive Chicago, IL 60601 (312) 565‑1234 Cover Image: Coronal head section of an E16.5 Cxcr4‑eGFP transgenic mouse, stained for GFP (green) and peripherin (red). Chemokine receptor CXCR4 is expressed in the olfactory epithelium, olfactory bulb, and peripherin‑positive olfactory axons. Fani Memi, Philipp Abe, Anna Cariboni, Fabienne MacKay, John G. Parnavelas, and Ralf Stumm, 2013, The Journal of Neuroscience, 33 (44): 17527‑17537. Complete Session Listing Sunday AM Sun. AM Sun. SPECIAL LECTURE McCormick Place SYMPOSIUM McCormick Place 096. Genetic Dissection of Neocortical Circuits — CME 098. Cellular and Circuit Mechanisms of Multisensory Integration and Plasticity — CME Sun. 8:30 AM - 9:40 AM — Hall B1 Speaker: Z. JOSH HUANG, Cold Spring Harbor Lab. Sun. 8:30 AM - 11:00 AM — S406A The computational power of the neocortex emerges from Chair: H. LEE a basic neural architectural plan rooted in the genome and Co-Chair: P. O. KANOLD conserved across species. Whereas a set of glutamatergic Multisensory integration occurs even at the early stages projection neurons constitute inter-areal processing of sensory processing across diverse organisms. Such streams and cortical output channels, diverse GABAergic interactions also serve as substrates for cross-modal interneuorns regulate the spatiotemporal configuration plasticity in the event of losing a sensory modality. This of neural ensembles. Systematic cell targeting and cell session will present recent evidence demonstrating synaptic fate mapping provide entry points for integrating multiple and circuit mechanisms of multisensory interactions approaches toward understanding the assembly and and cross-modal plasticity. Mechanisms underlying the organization of cortical circuits. This lecture will discuss the development of multisensory circuits and their adaptive progress and prospect on genetic targeting of glutamatergic plasticity in adults will be highlighted. and GABAergic neurons in the mouse, focusing on the 8:30 98.01 Introduction. construction and function of a chandelier cell-pyramidal cell module. 8:35 98.02 Cellular mechanisms underlying temporal tuning of multisensory integration. C. D. AIZENMAN. Brown Univ. 9:10 98.03 Cross-modal synaptic plasticity in adult cortex. H. SYMPOSIUM McCormick Place LEE. Johns Hopkins Univ. 097. Identifying and Manipulating the Synapses, Cells, and 9:45 98.04 Crossmodal induced refinement of intracortical Circuits of Memory Engrams: Implications for Memory circuits. P. O. KANOLD. Univ. of Maryland. and Memory Disorders — CME 10:20 98.05 Multisensory processing within cortico-cortical Sun. 8:30 AM - 11:00 AM — S100A and thalamocortical networks: Mechanisms, ontogeny and behavioral correlates. I. HANGANU-OPATZ. Univ. Med. Ctr. Chair: A. JOSE SILVA Hamburg-Eppendorf. Ground-breaking technological developments in neuroscience have transformed efforts to identify, 10:55 98.06 Closing Remarks. understand, and manipulate the engram at a synaptic, cellular and circuit level. This symposium will review these advances and discuss their implications for the MINISYMPOSIUM McCormick Place understanding of memory as well as memory disorders. 099. Transcriptomic Approaches to Neural 8:30 97.01 Introduction. Regeneration — CME 8:35 Deactivating hippocampal fear memories: 97.02 Sun. 8:30 AM - 11:00 AM — S105 Implications for psychiatric and memory disorders. C. A. DENNY. Columbia Univ. Chair: M. H. TUSZYNSKI Understanding why injured adult central nervous system 9:10 97.03 Genetic control of memory circuits. M. MAYFORD. axons fail to regenerate remains a central challenge of The Scripps Res. Inst, Inst. Childhood & Neglected Dis. neuroscience research. Recently, the use of high-throughput 9:45 97.04 Synaptic, cellular and circuit mechanisms that genetic screening has greatly illuminated the molecular link contextual memories across time. A. J. SILVA. Univ. of mechanisms governing neuronal regeneration programs. California-Los Angeles Med. Ctr. This minisymposium will highlight how transcriptomics approaches have led to the identification of novel regulatory 10:20 97.05 Identification and engineering of memory engram networks and molecular targets that can be successfully cells. S. TONEGAWA. Massachusetts Inst. Technol. manipulated to promote axon regeneration. 10:55 97.06 Closing Remarks. 8:30 99.01 Introduction. 8:35 99.02 A systems-level analysis of the peripheral nerve intrinsic axonal growth program. V. CHANDRAN. Univ. of California - Los Angeles. 8:55 99.03 Transcriptome and high content analysis reveal coding and non-coding RNAs in sensory neuron plasticity and axon regeneration. J. K. LERCH. The Ohio State Univ. Col. of Med. • Indicated a real or perceived conflict of interest, see page 152 for details. Neuroscience 2015 | Sunday AM | 1 Indicates a high school or undergraduate student presenter. * Indicates abstract’s submitting author 9:15 99.04 Genome-wide transcriptional changes elicited by MINISYMPOSIUM McCormick Place peripheral nerve injury. A. ANTUNES-MARTINS. King’s Col. London. 101. Learning to Generalize: Neural, Behavioral, and Computational Basis of Categorization — CME 9:35 99.05 cAMP-induced CREB sufficient/AP1-dependent transcriptional programs in axon regeneration. D. E. WILLIS. Sun. 8:30 AM - 11:00 AM — S406B Burke Med. Res. Inst. Chair: M. V. CHAFEE 9:55 99.06 The role of the activin cascade in CNS axonal Co-Chair: H. MERCHANT growth. M. COSTIGAN. Children’s Hosp. Boston, Harvard The ability to group objects and events into flexible Med. Sch. categories depending on their behavioral utility is fundamental to many forms of intelligent behavior 10:15 99.07 “Omics” insights into corticospinal tract shared between human and nonhuman primates. This regeneration. J. N. DULIN. Univ. of California - San Diego. minisymposium will synthesize alternative views of how 10:35 99.08 Closing Remarks. the brain implements categorization based on studies of statistical learning in humans, lesions in monkeys, the activity of single neurons and dynamics of cortical networks MINISYMPOSIUM McCormick Place in monkeys, as well as the properties of computational models. 100. Sex-Specific Mechanisms of Stress 8:30 101.01 Introduction. Susceptibility — CME 8:35 101.02 Relative and absolute representation of temporal Sun. 8:30 AM - 11:00 AM — S103 and spatial categories in the primate pre-SMA. H. Chair: D. BANGASSER MERCHANT. Inst. de Neurobiologia UNAM. Co-Chair: M. R. FARRELL 8:55 101.03 Executive control of categorization in the prefrontal- Stress-related mental illnesses are twice as prevalent in parietal network. M. V. CHAFEE. Univ. Minnesota. women as in men. Because many factors that contribute to pathology are likely sex-dependent, the development 9:15 101.04 Categorization: The roles of prefrontal and of improved treatments for both men and women relies temporal. M. A. ELDRIDGE. NIMH. on preclinical studies that include both male and female 9:35 101.05 Neural circuit basis of category learning in the animals. This minisymposium will highlight recent advances prefrontal cortex and striatum. E. K. MILLER. Massachusetts in rodent models that dissect the genes, hormones, and Inst. Technol. circuits that underpin sex differences in the brain’s response to stress. 9:55 101.06 Incidental auditory category learning. L. L. HOLT. Carnegie Mellon Univ. 8:30 100.01 Introduction. 10:15 101.07 Neural mechanisms of category learning: A tale of 8:35 100.02 Sex differences in receptors: “Micro” differences two approaches. X. WANG. New York Univ. with “macro” implications for the treatment of stress-related psychiatric disorders. D. BANGASSER. Temple Univ. 10:35 101.08 Closing Remarks. 8:55 100.03 Sex-specific activation of the Nucleus Accumbens transcriptome