Table S4. Proteins in the first and secondary interactomes of beta-Catenin I. Genes/proteins in the first interactome of betaCatenin UniProtKB Genes in the UniProtKB Query Gene Entry Interactome Entry Protein Name CTNNB1 P35222 MUC1 P15941 Mucin-1 BTRC Q9Y297 F-box/WD repeat-containing protein 1A AR A0A0B4J1T2 Androgen receptor SMAD3 P84022 Mothers against decapentaplegic homolog 3 UBC P0CG48 Polyubiquitin-C PSEN1 P49768 Presenilin-1 NR5A2 O00482 Nuclear receptor subfamily 5 group A member 2 TRRAP Q9Y4A5 Transformation/transcription domain-associated protein AXIN1 O15169 Axin-1 HDAC1 Q13547 Histone deacetylase 1 GSK3B P49841 Glycogen synthase kinase-3 beta TCF4 P15884 Transcription factor 4 CUL1 Q13616 Cullin-1 RUVBL1 Q9Y265 RuvB-like 1 CTNNA1 P35221 Catenin alpha-1 CHD8 Q9HCK8 Chromodomain-helicase-DNA-binding protein 8 PTPRF P10586 Receptor-type tyrosine-protein phosphatase F PARD3 Q8TEW0 Partitioning defective 3 homolog AXIN2 Q9Y2T1 Axin-2 EGFR P00533 Epidermal growth factor receptor MEN1 O00255 Menin TCF7L2 Q9NQB0 Transcription factor 7-like 2 FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 CTNNBIP1 Q9NSA3 Beta-catenin-interacting protein 1 CDH5 P33151 Cadherin-5 APC P25054 Adenomatous polyposis coli protein SKP1 P63208 S-phase kinase-associated protein 1 CREBBP Q92793 CREB-binding protein CDH1 P12830 Cadherin-1 RUVBL2 X6R2L4 RuvB-like 2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 LEF1 Q9UJU2 Lymphoid enhancer-binding factor 1 BCL9 O00512 B-cell CLL/lymphoma 9 protein CDH3 P22223 Cadherin-3 TCF7 P36402 Transcription factor 7 CDH2 P19022 Cadherin-2 PITX2 Q99697 Pituitary homeobox 2 RBBP5 Q15291 Retinoblastoma-binding protein 5 APC2 O95996 Adenomatous polyposis coli protein 2 II. Genes/proteins in the Secondary Interactome of beta-Catenin (Genes interacting with the genes in the first interactome of beta-Catenin) UniProtKB Genes in the UniProtKB Query Gene Entry Interactome Entry Protein Name MUC1 P15941 SRC P12931 Proto-oncogene tyrosine-protein kinase Src EGFR P00533 Epidermal growth factor receptor CTNNB1 P35222 Catenin beta-1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa BTRC Q9Y297 OGT O15294 subunit HIVEP1 P15822 Zinc finger protein 40 C13orf34 B5LMG6 Aurora borealis NUDC Q9Y266 Nuclear migration protein nudC NFKB2 Q00653 Nuclear factor NF-kappa-B p100 subunit SKP1 P63208 S-phase kinase-associated protein 1 USP47 Q96K76 Ubiquitin carboxyl-terminal hydrolase 47 IKBKB J3KNS5 Inhibitor of nuclear factor kappa-B kinase subunit beta NFKB1 P19838 Nuclear factor NF-kappa-B p105 subunit APC P25054 Adenomatous polyposis coli protein HIVEP2 P31629 Transcription factor HIVEP2 CTNNB1 P35222 Catenin beta-1 CDC25A P30304 M-phase inducer phosphatase 1 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 MED20 Q9H944 Mediator of RNA polymerase II transcription subunit 20 CLPX O76031 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial SMAD4 Q13485 Mothers against decapentaplegic homolog 4 CLSPN Q9HAW4 Claspin SNAI1 O95863 Zinc finger protein SNAI1 TUBGCP3 Q96CW5 Gamma-tubulin complex component 3 CDC34 P49427 Ubiquitin-conjugating enzyme E2 R1 NRD1 B1AKJ5 Nardilysin FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 PDCD4 Q53EL6 Programmed cell death protein 4 NFKBIA P25963 NF-kappa-B inhibitor alpha CUL1 Q13616 Cullin-1 AR A0A0B4J1T2 TGFB1I1 O43294 Transforming growth factor beta-1-induced transcript 1 protein PIAS2 A0A0A0MS92 E3 SUMO-protein ligase PIAS2 NCOA4 Q13772 Nuclear receptor coactivator 4 NCOA2 Q15596 Nuclear receptor coactivator 2 MDM2 J3KN53 E3 ubiquitin-protein ligase Mdm2 RB1 P06400 Retinoblastoma-associated protein EGFR P00533 Epidermal growth factor receptor KLK3 P07288 Prostate-specific antigen RNF14 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RCHY1 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 EP300 Q09472 Histone acetyltransferase p300 SRC P12931 Proto-oncogene tyrosine-protein kinase Src STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP HDAC1 Q13547 Histone deacetylase 1 TMPRSS2 O15393 Transmembrane protease serine 2 SMAD3 P84022 Mothers against decapentaplegic homolog 3 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 SMARCA4 P51532 Transcription activator BRG1 UBC P0CG48 Polyubiquitin-C HSP90AA1 P07900 Heat shock protein HSP 90-alpha CREBBP Q92793 CREB-binding protein CTNNB1 P35222 Catenin beta-1 PA2G4 Q9UQ80 Proliferation-associated protein 2G4 SP1 P08047 Transcription factor Sp1 KAT5 Q92993 Histone acetyltransferase KAT5 NCOA3 Q9Y6Q9 Nuclear receptor coactivator 3 NCOA1 Q15788 Nuclear receptor coactivator 1 NCOR2 Q9Y618 Nuclear receptor corepressor 2 NCOR1 O75376 Nuclear receptor corepressor 1 STAT3 P40763 Signal transducer and activator of transcription 3 SMAD3 P84022 AR A0A0B4J1T2 Androgen receptor CTNNB1 P35222 Catenin beta-1 HDAC1 Q13547 Histone deacetylase 1 JUN P05412 Transcription factor AP-1 NEDD9 Q14511 Enhancer of filamentation 1 RUNX2 Q13950 Runt-related transcription factor 2 SKI P12755 Ski oncogene MAPK1 P28482 Mitogen-activated protein kinase 1 SMURF2 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 KAT2B Q92831 Histone acetyltransferase KAT2B ZEB2 O60315 Zinc finger E-box-binding homeobox 2 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 CREBBP Q92793 CREB-binding protein TFE3 P19532 Transcription factor E3 SP1 P08047 Transcription factor Sp1 PIN1 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 SKIL P12757 Ski-like protein EP300 Q09472 Histone acetyltransferase p300 ZFYVE9 O95405 Zinc finger FYVE domain-containing protein 9 RNF111 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia SMAD4 Q13485 Mothers against decapentaplegic homolog 4 SMURF1 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 TRIM33 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 UBC P0CG48 Polyubiquitin-C UBC P0CG48 ABCA1 O95477 ATP-binding cassette sub-family A member 1 ACTB P60709 Actin, cytoplasmic 1 APOBEC3G Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G AR A0A0B4J1T2 Androgen receptor ARHGEF7 Q14155 Rho guanine nucleotide exchange factor 7 ATP1B1 P05026 Sodium/potassium-transporting ATPase subunit beta-1 ATXN3 D3VVP3 Ataxin 3 variant h AUP1 Q9Y679 Ancient ubiquitous protein 1 BECN1 Q14457 Beclin-1 BIRC6 Q9NR09 Baculoviral IAP repeat-containing protein 6 BMI1 P35226 Polycomb complex protein BMI-1 BRCA1 P38398 Breast cancer type 1 susceptibility protein BRCA2 P51587 Breast cancer type 2 susceptibility protein BRCC3 H9KVA9 Lys-63-specific deubiquitinase BRCC36 CCDC50 Q8IVM0 Coiled-coil domain-containing protein 50 CCT4 P50991 T-complex protein 1 subunit delta CDK9 P50750 Cyclin-dependent kinase 9 CDKN2A A0A0A0MRI0 Cyclin-dependent kinase inhibitor 2A COPS5 Q92905 COP9 signalosome complex subunit 5 CRKL P46109 Crk-like protein CXCR4 P61073 C-X-C chemokine receptor type 4 DAPK1 P53355 Death-associated protein kinase 1 DDX58 O95786 Probable ATP-dependent RNA helicase DDX58 DHX9 Q08211 ATP-dependent RNA helicase A DNTT P04053 DNA nucleotidylexotransferase E2F1 Q01094 Transcription factor E2F1 EIF3A Q14152 Eukaryotic translation initiation factor 3 subunit A EPN1 Q9Y6I3 Epsin-1 EPS15 P42566 Epidermal growth factor receptor substrate 15 ETS1 P14921 Protein C-ets-1 FAF1 Q9UNN5 FAS-associated factor 1 FAM175A Q6UWZ7 BRCA1-A complex subunit Abraxas FBP1 P09467 Fructose-1,6-bisphosphatase 1 FGFR1 P11362 Fibroblast growth factor receptor 1 FOXO1 Q12778 Forkhead box protein O1 FOXO4 P98177 Forkhead box protein O4 FTL P02792 Ferritin light chain FYN P06241 Tyrosine-protein kinase Fyn G6PD P11413 Glucose-6-phosphate 1-dehydrogenase GNAS Q5JWF2 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas GPI P06744 Glucose-6-phosphate isomerase H2AFX P16104 Histone H2AX HDAC1 Q13547 Histone deacetylase 1 HIST2H2BE Q16778 Histone H2B type 2-E HNRNPA3 P51991 Heterogeneous nuclear ribonucleoprotein A3 HNRNPH1 P31943 Heterogeneous nuclear ribonucleoprotein H HNRNPK P61978 Heterogeneous nuclear ribonucleoprotein K HSF2 Q03933 Heat shock factor protein 2 HTT P42858 Huntingtin IGHG1 A0A0A0MS08 Ig gamma-1 chain C region (Fragment) IKBKE Q14164 Inhibitor of nuclear factor kappa-B kinase subunit epsilon IKBKG Q9Y6K9 NF-kappa-B essential modulator INPP5D Q92835 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 IRAK1 P51617 Interleukin-1 receptor-associated kinase 1 ITCH Q96J02 E3 ubiquitin-protein ligase Itchy homolog JAK2 O60674 Tyrosine-protein kinase JAK2 JUN P05412 Transcription factor AP-1 KLF5 Q13887 Krueppel-like factor 5 KRT18 P05783 Keratin, type I cytoskeletal 18 L1CAM P32004 Neural cell adhesion molecule L1 LDHA P00338 L-lactate dehydrogenase A chain MAP3K1 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 MAVS Q7Z434 Mitochondrial antiviral-signaling protein MCL1 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 MDC1 Q14676 Mediator of DNA damage checkpoint protein 1 MDM2 J3KN53 E3 ubiquitin-protein ligase Mdm2 MDM4 O15151 Protein Mdm4 MYC P01106 Myc proto-oncogene protein MYLIP Q8WY64 E3 ubiquitin-protein ligase MYLIP NCOA3 Q9Y6Q9 Nuclear receptor coactivator 3 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 NEDD4L Q96PU5 E3 ubiquitin-protein ligase NEDD4-like NFE2L1 J9JIE5 Nuclear factor erythroid 2-related factor 1 NFE2L2 Q16236 Nuclear factor erythroid 2-related factor 2 NHLRC1 Q6VVB1 E3 ubiquitin-protein ligase NHLRC1 NTRK1 J3KP20 Tyrosine-protein kinase receptor OCLN Q16625 Occludin OTUD7B Q6GQQ9 OTU domain-containing protein 7B PARK2 O60260 E3 ubiquitin-protein ligase parkin PARP1 P09874 Poly [ADP-ribose]