® SUMMER 2014 VOLUME 14 / ISSUE 1 A publication dedicated to providing timely and accurate anti-doping information for New Discoveries by Scientific Working those involved and interested in the Olympic and Paralympic Group Could Advance Ability to Detect Movement. hGH Doping in Sport In This Issue: Building on the existing tests for growth hormone (GH) detection window. The biomarkers test, which measures Congrats Ambassadors! abuse in sport, scientists continue to make advancements serum concentrations of IGF-1 and another protein See which TrueSport Ambassadors took home medals in Sochi… in successfully detecting doping in sport. Now, breaking produced by the action of GH, has a much longer Read more on Pg 2 research appearing in Clinical Chemistry, the journal of detection window, potentially up to a number of weeks. the American Association of Clinical Chemistry, shows The two tests complement each other, and could be Habitat For Humanity that measuring insulin-like growth factor 1 (IGF-1) used in tandem to greatly enhance the ability to detect USADA lends a helping hand to the local community… as a biomarker of GH activity, through a chemistry prohibited GH use by athletes. Read more on Pg 3 technique known as liquid chromatography-tandem mass Athletes purportedly abuse GH to obtain its muscle- spectrometry (LC-MS/MS), could increase the ability to building and fat breakdown activity. Some actions of GH PED Use More Prevalent Than HIV detect GH doping and enhance inter-laboratory precision. A new study highlights the prevalence are the result of increased IGF-1 concentrations in the and risk of PED use… A team of researchers from five laboratories in three blood from the response of the liver to GH stimulation. Read more on Pg 4 countries, formed an unprecedented international Anecdotal evidence suggests that IGF-1 abuse may also working group on this topic, led by USADA’s Chief be on the rise. Side effects of this abuse include diabetes, Energy Drinks vs. Sports Drinks Science Officer, Larry D. Bowers Ph.D. and funded by aggravation of heart disease, and abnormal organ growth, Learn the differences between these often-confused categories… the Partnership for Clean Competition (PCC). The PCC among others. Read more on Pg 5 is a unique research collaborative founded by USADA, “Not only are these research results groundbreaking, but the United States Olympic Committee (USOC), Major the selfless work and cooperation of the members of this Ask the Scientists League Baseball (MLB), and the National Football League The experts weigh in on IV infusions for working group, with the PCC’s support, demonstrates (NFL) for the express purpose of supporting the world’s re-hydration and recovery… the power of collaborative research,” said Bowers, USADA Read more on Pg 5 top scientists and innovators in conducting high quality Chief Science Officer and PCC Scientific Advisory Board anti-doping research and development, to help generate Chair. “Bringing together top scientists and innovators Paralympics Place effective methods and resources for detecting and in focused research to identify and resolve analytical Learn about the newest Paralympic sport’s deterring the use of performance-enhancing substances debut at Sochi… problems is critical to advancing anti-doping science.” and methods. Read more on Pg 6 Additionally, the PCC IGF-1 LC-MS/MS working group’s The working group, established in 2011 as part of an study demonstrates the benefits of the harmonization of TrueSport Launches in Sport Camps initiative to develop new tests for GH biomarkers, See where TrueSport is taking its first – or ensuring uniformity among – clinical laboratory test has demonstrated that using LC-MS/MS instead of summer of camps… results, an important healthcare issue. Read more on Pg 7 antibodies to measure IGF-1 concentrations increases “In addition to being an important anti-doping testing measurement precision. For anti-doping purposes, the Anti-Doping Word Search LC-MS/MS method has a second significant advantage advancement, new testing methodology arising from Test your anti-doping knowledge and over immunoassay – as IGF-1 is identified in addition these findings could also aid in the diagnosis and word-search skills… to being quantified. The results may contribute to the treatment of disorders caused by the natural over- or Read more on Pg 8 development and global adoption of the biomarkers GH under-production of GH,” said Andy Hoofnagle, M.D., test in anti-doping. Ph.D, and an associate professor of Laboratory Medicine and Pathology at the University of Washington and a THE SPIRIT OF SPORT Currently, two approaches have been developed for senior author on the paper. IS GOING DIGITAL- detecting GH in sport applications. The GH isoforms instead of being printed in test, reported in Clinical Chemistry in 20091, has been hardcopy, regular updates can successfully used for a number of years to identify 1 Bidlingmaier M, Suhr J, Ernst A, Wu Z, Keller A, Strasburger CJ, Bergmann A. now be found at USADA.org/ athletes abusing GH; however, it is limited by a short High-sensitivity chemiluminescence immunoassays for detection of growth hormone resources/spirit-of-sport/ doping in sports. Clin Chem. 2009 Mar;55(3):445-53. Page 1 SPIRIT OF SPORT® VOLUME 14 / ISSUE 1 Congrats Ambassadors and Medal Winners! USADA Lends a Helping Hand Several TrueSport Athlete Ambassadors represented the United States nobly at GOLD MEDALS USADA’s staff is committed to serving our While Habitat for Humanity often conjures up Special thanks to the Volunteers: the 2014 Sochi Olympics and demonstrated TrueSport principles both in-and- Jamie Anderson (Snowboarding – Women’s Slopestyle) community throughout the year, and in March images of raising walls and hammering nails, out-of-competition. Maddie Bowman (Freestyle Skiing – Women’s Halfpipe) Brittany Bender Dave Knutson Joss Christensen (Freestyle Skiing – Men’s Slopestyle) we kicked off our 2014 service initiative by there are a variety of ways available for volunteers The third time was a charm for Erin Hamlin. Not only did the luger from Meryl Davis (Figure Skating – Mixed Ice Dance) volunteering with Pikes Peak Habitat for Humanity. to help. In this case, USADA’s staff worked on a Betsy Douglass Kyle McKinnis Remsen, New York win her first personal medal; she also became the first Kaitlyn Farrington (Snowboarding – Women’s Halfpipe) stone retaining wall behind an otherwise nearly- Employees across all of USADA’s departments met Jennifer Dodd Lisa McCumber American luger of either gender to win a medal in singles luge. Ice Sledge Hockey completed house. While some volunteers dug a in Fountain, Colorado to work with other Habitat Sage Kotsenburg (Snowboarding – Men’s Slopestyle) trench and leveled the foundation of the wall, Andrew Elsass Lindsey Roebken Bobsledder Lauryn Williams also made history. With her silver as part of volunteers to help build homes that will eventually Ted Ligety (Alpine Skiing – Men’s Giant Slalom) others solidified the existing work by pounding the two-woman bobsleigh team, she became just one of five athletes to win house more than 30 families. Members of our staff Nick Esares Shikha Tandon Mikaela Shiffrin (Alpine Skiing – Women’s Slalom) rebar and pouring gravel. a medal in both the Summer and Winter Games, including becoming the donated 56 man-hours helping to build retaining Evan Strong (Para Alpine Skiiing) Donna Harris Vicki Vaughan first American woman to accomplish the feat. Williams also medaled at the David Wise (Freestyle Skiing – Men’s Halfpipe) walls for a nearly completed home. Over 90% of At the end of the day, volunteers were invited London 2012 and Athens 2004 Olympics in the 4 x 100 m relay and 100 m, Charlie White (Figure Skating – Mixed Ice Dance) the work on each home is completed by volunteers. inside one of the nearly-finished homes. There was Lani Hawes Johncie Wingard respectively. an overwhelming sense of goodwill, and USADA In order to qualify for a zero interest, 30-year Jennifer Jago Eric Young will continue to volunteer their time for more There was also TrueSport representation at the Sochi Paralympics, where SILVER MEDALS mortgage home, a family must meet a financial or Eduardo Alvarez (Short-Track Speedskating – Men’s 5000m Relay) worthwhile causes in the months and years ahead. Augusto Perez participated in his third Games. Perez competed in three situational need, be willing to put in 350-450 hours Mark Bathum (Para Alpine Skiing) events in two sports; the 15km- sitting and 4x2.5km open relay cross- of ‘sweat equity’, and take finance classes. Heath Calhoun (Para Alpine Skiing) country skiing events and in biathlon’s 12.5km- sitting event. John Celski (Short-Track Speedskating – Men’s 5000m Relay) TrueSport Ambassadors give back to the sports they love and to the next Christpoher Creveling (Short-Track Speedskating – Men’s 5000m Relay) generation of athletes by advocating for the development of character and Gus Kenworthy (Freestyle Skiing – Men’s Slopestyle) Devin Logan (Freestyle Skiing – Women’s Slopestyle) integrity in athletes as well as the achievement of healthy performance Jordan Malone (Short-Track Speedskating – Men’s 5000m Relay) strategies for sport and life. We’re proud that these Ambassadors represent Oksana Masters (Para Cross-Country Skiing) TrueSport through personal stories of clean sport, sportsmanship, and peak Tatyana McFadden (Para Cross-Country Skiing) performance. Elana Meyers (Bobsled – Women’s 2-Man Competition) USADA and TrueSport would