VolumeVolume 15 1 -- NumberNumber 81 MayAugust - September 2011 1997 Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Scope The Atlas of Genetics and Cytogenetics in Oncology and Haematology is a peer reviewed on-line journal in open access, devoted to genes, cytogenetics, and clinical entities in cancer, and cancer-prone diseases. It presents structured review articles ("cards") on genes, leukaemias, solid tumours, cancer-prone diseases, more traditional review articles on these and also on surrounding topics ("deep insights"), case reports in hematology, and educational items in the various related topics for students in Medicine and in Sciences. Editorial correspondance Jean-Loup Huret Genetics, Department of Medical Information, University Hospital F-86021 Poitiers, France tel +33 5 49 44 45 46 or +33 5 49 45 47 67 [email protected] or [email protected] Staff Mohammad Ahmad, Mélanie Arsaban, Marie-Christine Jacquemot-Perbal, Maureen Labarussias, Vanessa Le Berre, Anne Malo, Catherine Morel-Pair, Laurent Rassinoux, Alain Zasadzinski. Philippe Dessen is the Database Director, and Alain Bernheim the Chairman of the on-line version (Gustave Roussy Institute – Villejuif – France). The Atlas of Genetics and Cytogenetics in Oncology and Haematology (ISSN 1768-3262) is published 12 times a year by ARMGHM, a non profit organisation, and by the INstitute for Scientific and Technical Information of the French National Center for Scientific Research (INIST-CNRS) since 2008. The Atlas is hosted by INIST-CNRS (http://www.inist.fr) http://AtlasGeneticsOncology.org © ATLAS - ISSN 1768-3262 The PDF version of the Atlas of Genetics and Cytogenetics in Oncology and Haematology is a reissue of the original articles published in collaboration with the Institute for Scientific and Technical Information (INstitut de l’Information Scientifique et Technique - INIST) of the French National Center for Scientific Research (CNRS) on its electronic publishing platform I-Revues. Online and PDF versions of the Atlas of Genetics and Cytogenetics in Oncology and Haematology are hosted by INIST-CNRS. Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Editor Jean-Loup Huret (Poitiers, France) Editorial Board Sreeparna Banerjee (Ankara, Turkey) Solid Tumours Section Alessandro Beghini (Milan, Italy) Genes Section Anne von Bergh (Rotterdam, The Netherlands) Genes / Leukaemia Sections Judith Bovée (Leiden, The Netherlands) Solid Tumours Section Vasantha Brito-Babapulle (London, UK) Leukaemia Section Charles Buys (Groningen, The Netherlands) Deep Insights Section Anne Marie Capodano (Marseille, France) Solid Tumours Section Fei Chen (Morgantown, West Virginia) Genes / Deep Insights Sections Antonio Cuneo (Ferrara, Italy) Leukaemia Section Paola Dal Cin (Boston, Massachussetts) Genes / Solid Tumours Section Louis Dallaire (Montreal, Canada) Education Section Brigitte Debuire (Villejuif, France) Deep Insights Section François Desangles (Paris, France) Leukaemia / Solid Tumours Sections Enric Domingo-Villanueva (London, UK) Solid Tumours Section Ayse Erson (Ankara, Turkey) Solid Tumours Section Richard Gatti (Los Angeles, California) Cancer-Prone Diseases / Deep Insights Sections Ad Geurts van Kessel (Nijmegen, The Netherlands) Cancer-Prone Diseases Section Oskar Haas (Vienna, Austria) Genes / Leukaemia Sections Anne Hagemeijer (Leuven, Belgium) Deep Insights Section Nyla Heerema (Colombus, Ohio) Leukaemia Section Jim Heighway (Liverpool, UK) Genes / Deep Insights Sections Sakari Knuutila (Helsinki, Finland) Deep Insights Section Lidia Larizza (Milano, Italy) Solid Tumours Section Lisa Lee-Jones (Newcastle, UK) Solid Tumours Section Edmond Ma (Hong Kong, China) Leukaemia Section Roderick McLeod (Braunschweig, Germany) Deep Insights / Education Sections Cristina Mecucci (Perugia, Italy) Genes / Leukaemia Sections Yasmin Mehraein (Homburg, Germany) Cancer-Prone Diseases Section Fredrik Mertens (Lund, Sweden) Solid Tumours Section Konstantin Miller (Hannover, Germany) Education Section Felix Mitelman (Lund, Sweden) Deep Insights Section Hossain Mossafa (Cergy Pontoise, France) Leukaemia Section Stefan Nagel (Braunschweig, Germany) Deep Insights / Education Sections Florence Pedeutour (Nice, France) Genes / Solid Tumours Sections Elizabeth Petty (Ann Harbor, Michigan) Deep Insights Section Susana Raimondi (Memphis, Tennesse) Genes / Leukaemia Section Mariano Rocchi (Bari, Italy) Genes Section Alain Sarasin (Villejuif, France) Cancer-Prone Diseases Section Albert Schinzel (Schwerzenbach, Switzerland) Education Section Clelia Storlazzi (Bari, Italy) Genes Section Sabine Strehl (Vienna, Austria) Genes / Leukaemia Sections Nancy Uhrhammer (Clermont Ferrand, France) Genes / Cancer-Prone Diseases Sections Dan Van Dyke (Rochester, Minnesota) Education Section Roberta Vanni (Montserrato, Italy) Solid Tumours Section Franck Viguié (Paris, France) Leukaemia Section José Luis Vizmanos (Pamplona, Spain) Leukaemia Section Thomas Wan (Hong Kong, China) Genes / Leukaemia Sections Atlas Genet Cytogenet Oncol Haematol. 2011; 15(8) Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Volume 15, Number 8, August 2011 Table of contents Gene Section ING4 (inhibitor of growth family, member 4) 626 Angela Greco, Claudia Miranda LRIG1 (leucine-rich repeats and immunoglobulin-like domains 1) 631 Dongsheng Guo, Baofeng Wang MAPK14 (mitogen-activated protein kinase 14) 634 Almudena Porras, Carmen Guerrero RAD51L3 (RAD51-like 3 (S. cerevisiae)) 638 Mary K Taylor, Michael K Bendenbaugh, Susan M Brown, Brian D Yard, Douglas L Pittman SLC9A3R1 (solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1) 643 Wendy S McDonough, Michael E Berens USP15 (ubiquitin specific peptidase 15) 651 Monica Faronato, Sylvie Urbé, Judy M Coulson CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)) 658 Joanna Fares, Linda Wolff, Juraj Bies DLX4 (distal-less homeobox 4) 664 Patricia E Berg, Saurabh Kirolikar IL17A (interleukin 17A) 668 Norimitsu Inoue, Takashi Akazawa MYBBP1A (MYB binding protein (P160) 1a) 673 Claudia Perrera, Riccardo Colombo PLCD1 (phospholipase C, delta 1) 676 Xiaotong Hu PYY (peptide YY) 680 Maria Braoudaki, Fotini Tzortzatou-Stathopoulou SIAH2 (seven in absentia homolog 2 (Drosophila)) 683 Jianfei Qi, Ze'ev Ronai TP53BP2 (tumor protein p53 binding protein, 2) 687 Kathryn Van Hook, Zhiping Wang, Charles Lopez Leukaemia Section 8p11 myeloproliferative syndrome (EMS, eight p11 myeloproliferative syndrome) 692 Paula Aranaz, José Luis Vizmanos i(5)(p10) in acute myeloid leukemia 701 Nathalie Douet-Guilbert, Angèle Herry, Audrey Basinko, Marie-Josée Le Bris, Nadia Guéganic, Clément Bovo, Frédéric Morel, Marc De Braekeleer Atlas Genet Cytogenet Oncol Haematol. 2011; 15(8) Atlast(11;14)(q 13;q32)of Genetics in multiple myeloma and Cytogenetics Huret JL, Laï JL in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS +20 or trisomy 20 (solely) 703 Jean-Loup Huret Deep Insight Section TMPRSS2:ETS gene fusions in prostate cancer 705 Julia L Williams, Maisa Yoshimoto, Alexander H Boag, Jeremy A Squire, Paul C Park Atlas Genet Cytogenet Oncol Haematol. 2011; 15(8) Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Review ING4 (inhibitor of growth family, member 4) Angela Greco, Claudia Miranda Dept Experimental Oncology, Molecular Mechanisms Unit, Istituto Nazionale Tumori IRCCS Foundation - via Venezian 1 - 20133 Milan Italy (AG, CM) Published in Atlas Database: December 2010 Online updated version : http://AtlasGeneticsOncology.org/Genes/ING4ID40978ch12p13.html Printable original version : http://documents.irevues.inist.fr/bitstream/DOI ING4ID40978ch12p13.txt This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology homology search for expressed tag clones with a Identity PHD finger motif (Shiseki et al., 2003). ING4 gene Other names: MGC12557; my036; p29ING4 is located on chromosome 12p13.31 and consists of HGNC (Hugo): ING4 eight exons encoding a 29-kDa protein expressed in multiple human tissues. Location: 12p13.31 Transcription DNA/RNA Multiple alternatively spliced transcript variants have been observed using different splice sites in Description the coding region; transcript variants span from ING4 belongs to family of highly homologous five 1461 bp to 1313 bp. members containing PHD domain and has been Wobble splicing events have been described at exon identified through a computational sequence 4 and 5 boundary. Figure adapted from Atlas of Genetics and Cytogenetics in Oncology and Haematology. Atlas Genet Cytogenet Oncol Haematol. 2011; 15(8) 626 ING4 (inhibitor of growth family, member 4) Greco A, Miranda C Different splicing variants have been identified regulation, chromatin remodeling, and regulation of (among them -v1, -v2, -v3 and -v4/Δ4AA) gene expression. Several ING4 partners have been involving 12 bp (379-390) and resulting in in frame described. Similarly to the other ING members, deletions of one to four aminoacids in NLS (Tsai ING4 was described to interact with p53 and to and Lin, 2006). modulate p53 transcriptional activity (Shiseki et al., Several splicing variants have been described 2003). The interaction of ING4 with p53 is lacking exon 2, 3 and 6 (entirely or in part), and mediated by