SunLong Biotech Co.,LTD Tel: 0086-571- 56623320 Fax:0086-571- 56623318 E-mail:[email protected] www.sunlongbiotech.com Rabbit Anti-Junctophilin 1/FITC Conjugated antibody SL17209R-FITC Product Name: Anti-Junctophilin 1/FITC Chinese Name: FITC标记的亲联蛋白1抗体 DKFZp762L0313; JP 1; JP1; JPH 1; JPH1; Junctophilin 1; Junctophilin type 1; Alias: Junctophilin type1; Junctophilin1; Mitsugumin 72; Mitsugumin72. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 72kDa Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human Junctophilin 1 Lsotype: IgG Purification: affinitywww.sunlongbiotech.com purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk Product Detail: between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. [provided by RefSeq, Jul 2008] Function: JPH1 (Junctophilin 1) contributes to the stabilization of junctional membrane complexes, which are a common feature of all excitable cells and mediate cross talk between the cell surface and intracellular ion channels. It may act by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum (ER/SR). It is composed of a C terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. Subcellular Location: Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane; Single pass type IV membrane protein (By similarity). Sarcoplasmic reticulum membrane; Single pass type IV membrane protein. Note: Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands. Database links: Entrez Gene: 56704 Human Omim: 605266 Human SwissProt: Q9HDC5 Human Unigene: 657367 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeuticwww.sunlongbiotech.com or diagnostic applications. .