Anti-Cd314 monoclonal antibody, clone 1D11 (CABT-48441MH) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse anti Human CD314 antibody, clone 1D11 recognizes CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding toCD314 results in NK cell activation and potent costimulation of effector T cells. Clone 1D11 is reported to inhibit T cell recognition of MICA. Flow Cytometry Use 10ul of the suggested working dilution to label 106 cells in 100ul. Specificity CD314 Immunogen NKL cells. Isotype IgG1 Source/Host Mouse Species Reactivity Human Clone 1D11 Conjugate Unconjugated Applications IHC-Fr; FC; IP Format Purified IgG - liquid Size 200 μg Preservative See individual product datasheet Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Warnings For research purposes only 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name KLRC4-KLRK1 KLRC4-KLRK1 readthrough [ Homo sapiens (human) ] Official Symbol KLRC4-KLRK1 Synonyms KLRC4-KLRK1; KLRC4-KLRK1 readthrough; NKG2-D type II integral membrane protein; NK cell receptor D; NKG2-D-activating NK receptor; killer cell lectin-like receptor subfamily K member 1; CD314; Entrez Gene ID 100528032 Protein Refseq NP_001186734.1 UniProt ID P26718 Chromosome Location 12p Pathway Adaptive Immune System; DAP12 interactions; DAP12 signaling; Immune System; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Innate Immune System; Malaria; Natural killer cell mediated cytotoxicity; Function carbohydrate binding; protein binding IPI; receptor activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.