Vishesh Rohatgi et al DOPING IN SPORTS- PAST, PRESENT AND FUTURE DOPING IN SPORTS- PAST, PRESENT AND FUTURE IJCRR Vishesh Rohatgi, Narayana Reddy S. Vol 04 issue 22 Section: Healthcare Department of Pharmacology, Bangalore Medical College and Research Institute, Category: Review Bangalore, India Received on: 15/08/12 Revised on: 07/09/12 Accepted on: 28/09/12 E-mail of Corresponding Author: [email protected] ABSTRACT Doping is widely known as the use of banned substances and practices by sports personnel particularly athletes in an attempt to improve sporting performances. There are at least two essential reasons to support the fight against doping: the depth of corruption on the „fair competition‟- the sine qua non of all sporting events, and the potential harmful effects on athletes. To ensure equal competitive conditions and to protect the health of athletes, the International Olympic Committee, WADA (World Anti-Doping Agency) and International Sports Federations have accepted use of performance-enhancing substances and methods by competitors directly or indirectly as „doping‟, and have forbidden them. Nevertheless, the desire to win for acclaim and/or associated benefits drives athletes to misuse these drugs and methods. When current antidoping programmes were developed, the most frequently used doping agents were xenobiotics, such as adrenergic stimulants and anabolic steroids that are readily detectable in urine with the use of gas chromatography and mass spectrometry. As effective and stringent laws came into effect, use of traditional doping agents were restrained but some athletes turned to other means to improve performance, including blood doping and use of recombinant peptide hormones such as Erythropoietin and insulin-like Growth factor-1. And hence highlighted the potential misuse of this technology and „gene doping‟ .With progress in genetic engineering, many other genes with this potential for abuse will be discovered and tried subsequently. For this reason, it is important to promote research and to develop timely legal regulations in the field of gene doping. Key words: doping, dope, sports, androgenic steroids, gene doping, biological passport INTRODUCTION Doping in sports is not a new phenomenon; The word „Dope‟ comes from the Dutch word Arthurian knights supposedly drank magical "doop"[1] (a thick dipping sauce) that entered potions from the cup of Merlin. The Ancient American slang to describe how robbers Olympics in Greece were filled with corruption stupefied victims by mixing tobacco with the and doping to such an extent that the games had seeds of Datura stramonium, known as to be dissolved. In Ancient Rome, gladiators used jimsonweed, which contains a number of tropine to drink herbal infusions to strengthen them alkaloids, causing sedation, hallucinations and before chariot races and going into battle [2] confusion. Int J Cur Res Rev, Nov 2012 / Vol 04 (22) Page 133 Vishesh Rohatgi et al DOPING IN SPORTS- PAST, PRESENT AND FUTURE Perhaps the most sinister of all is the publication experienced androgenic changes.[2], [3] Heidi of the book "Faust's Gold" which gives an in- Krieger, the GDR shot-putter had so many depth look at the systematic doping machine testosterone injections that she opted for a sex implemented by the German Democratic change operation and now lives as Mr. Andreas Republic (GDR) in the 1970s. Many of the Krieger. It is estimated that around 10,000 athletes were given performance enhancing athletes were processed through the GDR doping agents and around 142 former female athletes machine. [2], [3] Figure 1 HEIDI KRIEGER ANDREAS KRIEGER A famous case of illicit use of androgenic Testosterone Cypionate, Furazabol, and Human steroids in a competition was Canadian Ben growth hormone amongst other things. Johnson Johnson's victory in the 100 m at the 1988 was therefore stripped of his gold medal and lost Summer Olympics. He failed the drug test when his recognition of what had been a world-record Stanozolol was found in his urine. He later performance. [4] admitted of using steroid as well as Dianabol, 1988 Summer Olympics (What played the trick)?? Ben Johnson Figure 2 Int J Cur Res Rev, Nov 2012 / Vol 04 (22) Page 134 Vishesh Rohatgi et al DOPING IN SPORTS- PAST, PRESENT AND FUTURE In 1998 the entire Festina cycling team were In November 1999, The World Anti-Doping excluded from the Tour de France following the Program [9] was developed and implemented to discovery of a team car containing large amounts harmonize anti-doping policies and of various performance-enhancing drugs. The regulations within sports‟ organizations and team director later admitted that few of them among governments. The three levels of the routinely given banned substances. Operación World Anti-Doping Program are: Puerto (Operation Mountain Pass) [5] is the code 1. World Anti-Doping Code (Code) name of a Spanish Police operation against the 2. International Standards doping network of Doctor Eufemiano Fuentes, 3. Models of Best Practice and Guidelines started in May 2006, which resulted in a scandal Levels 1 (Code) and 2 (International Standards) that involved several of the world most famous are mandatory for all Code signatories. cyclists at the time. Level 3 (Models of Best Practice and Guidelines, India has been making strides on the international including Model Rules) is recommended by sports scene and now has been associated with WADA, and is made available to Code what often comes with success — a doping signatories upon request but is not mandatory. scandal. Indian team players in the 4x400-meter And since then, Doping is defined as the relay squad that won gold at the Commonwealth occurrence of one or more of the anti-doping rule and Asian games were among eight track and violations set forth in the Code [9]. The Code is field athletes banned for out-of-competition the fundamental and universal document upon doping violations. While the trial is going on, which the World Anti- Doping Program in sports according to athletes, they tested positive due to is based. [9] Going upon WADA standards, intake of Ginseng found commonly in various National Anti-Doping agency was established in ayurvedic products as well as many March 2008, which follows the Code. health/nutritional supplements [6] like Revital. In February 2011, the United States Olympic Ginseng has been used as an energy booster; Committee and the Ad Council launched an anti- ginseng root does not contain prohibited steroid campaign called Play Asterisk Free, substances, but products containing ginseng have which was aimed at teens. The campaign first tested positive for ephedrine. [7] launched in 2008 under the name "Don't Be an No game is spared from doping. In Kabaddi Asterisk" world cup 2011, India lifted the title. It was found Anti-doping research (ADR) contributes to the out later that 53 players including an Indian development and implementation of efficient player were tested positive for anabolic steroids. programs for the control of doping and to provide [8] much needed information and education Fighting to save the soul of sport regarding doping to the concerned sports bodies In 1967 The International Olympic Committee as well as the public. It utilizes research, (IOC) was established in order to deal with the analytical services and education to identify increasing problem of doping in the sports world. dangerous and banned substances in sports and The initial goal of putting in place an anti-doping help halt their use. In 2009, Anti doping research structure was rapidly widened to encompass the developed an equine test for the blood-boosting following three fundamental principles: drug CERA (short for the brand name Mircera; Protection of the health of athletes. also known as Continuous erythropoietin receptor Respect for both medical and sport ethics. activator).[10] Testing and analysis of samples are Equality for all competing athletes. done in WADA-accredited laboratories and the results are reviewed and notified and appropriate Int J Cur Res Rev, Nov 2012 / Vol 04 (22) Page 135 Vishesh Rohatgi et al DOPING IN SPORTS- PAST, PRESENT AND FUTURE action taken including suspension from athletics and forfeiture of medals, points and prizes. Continuous Erythropoietin Receptor activator Figure 3 Athletes seeking to avoid testing positive for intravenously. Beta-blockers are banned in doping use various methods to cheat on the drug control sports only e.g. archery, shooting, tests. The most common methods include: bobsleigh, snooker, darts, and synchronized Urine replacement, which involves swimming. Alcohol is banned in sports such as replacing dirty urine with clean urine from motor-racing and shooting where performance of someone who is not taking banned skilled tasks may be affected. [12], [13] substances. Urine replacement can be done Many athletes do not realise that caffeine is also by catheterization or with a prosthetic penis banned in sport; a level greater than 12 such as The Original Whizzinator. micrograms/ml constitutes an offence. Many of Diuretics, used to cleanse the system (dilute the over the counter analgesics contain caffeine the urine) before having to provide a sample. as do beverages, sports drinks and dietary Blood transfusions, which increase the supplements. [14] blood's oxygen carrying capacity, could Doping in Sports: Future trigger a positive test result without the Gene doping is defined as the "non therapeutic presence of drugs use of cells, genes, genetic elements, or Banned Drugs modulation of gene expression, having the According to WADA 2011 prohibited list [11] capacity to improve athletic performance"[15] prohibited drugs include (list not complete) Gene doping is done using techniques developed Anabolic Androgenic Steroids (AAS): for gene therapy. The most commonly used Testosterone, Stanozolol, Danazol method is a viral vector, a “delivery vehicle” that Peptide hormones, growth factors and related does not cause disease, contains the gene of substances interest, and can be engineered to inject this gene Erythropoietin (EPO), Insulin, Growth hormone, into a specific type of tissue.