Cancer Center Grand Rounds Yi Zhang, PhD Investigator, Howard Hughes Medical Institute Fred Rosen Professor of Pediatrics, Boston Children’s Hospital Professor of Genetics, Harvard Medical School “Role of H3K27me3-Mediated Genomic Imprinting in Development & SCNT Reprogramming” Mammalian sperm and oocytes have different epigenetic landscapes and are organized in different fashion. Following fertilization, the initially distinct parental epigenomes become largely equalized with the exception of certain loci including imprinting control regions (ICRs). How parental chromatin becomes equalized and how ICRs escape from this reprogramming is largely unknown. Based on allelic chromatin accessibility and gene expression analyses, we identified a DNA methylation-independent, H3K27me3-dependent imprinting mechanism. We demonstrate H3K27me3-mediated genomic imprinting plays an important role in imprinted X-chromosome inactivation, placenta development, and somatic cell nuclear transfer reprogramming. Tuesday, September 11, 2018 12:00pm – 1:00pm NRT-LG, Aresty Auditorium Lunch is promptly at 11:30 am Please be sure to sign in to obtain CME credit PRESENTATION OBJECTIVES: Following participation in this activity, the participants will learn: GLOBAL OBJECTIVE: a. Apply new advances and emerging knowledge in clinical to practice b. Synthesize laboratory and basic science insight to clinical applicable therapeutic trials c. Evaluate and compare practice strategies to improve delivery of quality cancer care DISCLOSURE: All have indicated that they have nothing to disclose (No commercial support was provided for this session) Accreditation Statement: The Keck School of Medicine of the University of Southern California is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Credit Designation: The Keck School of Medicine of the University of California designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Webcast: http://keckmedia.usc.edu/NorrisGR .