Curriculum Vitae Yasuhiro Torashima, MD, PhD Nagasaki University School of Medicine April 2018 1 Yasuhiro Torashima, MD, PhD Sex: Male Place of Birth: Nagasaki, Japan Business Address: 1-12-4 Sakamoto Nagasaki-shi, 852-85 Japan E-mail Address: [email protected] Education: Medical School Apr. 1992 – March. 1998 Nagasaki University, Nagasaki, Japan School of medicine Post-graduate School Apr. 2004 – March 2009 Nagasaki University Graduate School of Biomedical Sciences, Department of Surgery, PhD course Medical Training & Professional Career: Apr. 2000 – March 2001 Nagasaki University Hospital, Nagasaki, Japan Intern in Surgery Apr. 2004 - March 2007 Department of Surgery Graduate school of biomedical Sciences Nagasaki University, Nagasaki, Japan Graduate Student and Clinical learning Apr. 2008 - May 2010 Department of Surgery Graduate school of biomedical Sciences Nagasaki University, Nagasaki, Japan Attending Staff June 2010 - June 2012 Children’s Hospital Los Angeles Saban Research Institute Research Fellow 2 July 2012 – March 2015 Department of Surgery Graduate school of biomedical Sciences Nagasaki University, Nagasaki, Japan Assistant Professor April 2015 – March 2017 Research and Development Division Health Policy Bureau Ministry of Health, Labour and Welfare Deputy Director April 2017 – March 2018 Division of Biobank, Department of Research Infrastructure Japan Agency for Medical Research and Development Manager April 2018 – Present Medical University Research Administrator Office (MEDURA) Nagasaki University School of Medicine Assistant Professor Medical License and Degree: Degree of Medical Doctor, 4/28/2000 Degree of Post-graduate Doctor, 2/2009 Specialty for Japanese Surgical Society, 11/2009 Society Memberships: Japan Surgical Society Japanese Society of Gastroenterological Surgery Japanese Society of Gastroenterology Japan Society of Coloproctolgy Japanese Gastroenterological Association Japanese Society for Regenerative Medicine, Executive Secretary 3 Research Support The Saban Research Institute Research Career Development Fellowship 7/1/2011-6/30/2012 Genetic Manipulation in Bioengineering: Overexpression of Fibroblast Growth Factor 10 (FGF10) to Optimize Mouse Tissue-Engineered Small Intestine (TESI) Role:Investigator Grant-in-Aid for Young Scientists (B) 4/1/2013- TESI from Cultured Intestinal stem cells Role:PI Nagasakiken Medical Association Research Grant 4/1/2013-3/31/2014 TESI from Cultured Intestinal stem cells Role:PI PUBLICATIONS: PAPERS 1) Torashima Y, Yamaguchi J, Taniguchi K, Fujioka H, Shimokawa I, Izawa K, Kanematsu T. Surgery for ileal mesenteric lymphangioma during pregnancy: case report and review of the literature. J Gastrointest Surg. 2004 Jul-Aug;8(5):616-20. Review. 2) Taniguchi K, Fujioka H, Torashima Y, Yamaguchi J, Izawa K, Kanematsu T. Rectal cancer with paraneoplastic nephropathy: association of vascular endothelial growth factor. Dig Surg. 2004;21(5-6):455-7. Epub 2005 Jan 19. 3) Torashima Y, Uezono Y, Kanaide M, Enjoji A, Kanematsu T, Taniyama K Presence of GABAB receptors forming heterodimers with GABAB1 and GABAB2 subunits in the human lower esophageal sphincter. J Pharmacol Sci. 2009;111(3):253-259 4) Haraguchi M, Fujita F, Torashima Y, Inokuma T, Tajima Y, Kanematsu T The serum level of carcinoembryonic antigen in drainage venous blood is not a sensitive predictor of metachronous hepatic metastasis for patients with colorectal cancer. Surg. Today 2010;40(8):745-751 5) Sala FG, Matthews JA, Speer AL, Torashima Y, Barthel ER, Grikscheit TC. A multicellular approach forms a significant amount of tissue-engineered small intestine in the mouse. Tissue Eng Part A. 2011 Jul;17(13-14):1841-50. 6) Barthel ER, Levin DE, Speer AL, Sala FG, Torashima Y, Hou X, Grikscheit TC. Human tissue-engineered colon forms from postnatal progenitor cells: an in vivo murine model. Regen Med. 2012 Nov;7(6):807-18. 7) Inokuma T, Haraguchi M, Fujita F, Torashima Y, Eguchi S, Kanematsu T. Suppression of reactive oxygen species develops lymph node metastasis in colorectal cancer. Hepatogastroenterology. 2012 Nov-Dec;59(120):2480-3. 4 8) Miyazaki K, Torashima Y, Mochizuki S, Susumu S, Kanetaka K, Eguchi S, Kanematsu T, Abe K, Fujita F. Hand-assisted laparoscopic subtotal colectomy with cecorectal anastomosis for chronic idiopathic colonic pseudo-obstruction: report of a case. Surg Today. 2014 Mar;44(3):581-5. 9) Barthel ER, Speer AL, Levin DE, Sala FG, Hou X, Torashima Y, Wigfall CM, Grikscheit TC. Tissue engineering of the intestine in a murine model. J Vis Exp. 2012 Dec 1;(70):e4279. 10) Levin DE, Barthel ER, Speer AL, Sala FG, Hou X, Torashima Y, Grikscheit TC. Human tissue-engineered small intestine forms from postnatal progenitor cells. J Pediatr Surg. 2013 Jan;48(1):129-37. 11) Torashima Y, Levin DE, Barthel ER, Speer AL, Sala FG, Hou X, Grikscheit TC. Fgf10 overexpression enhances the formation of tissue-engineered small intestine. J Tissue Eng Regen Med. 2013 Mar 7. 12) Levin DE, Sala FG, Barthel ER, Speer AL, Hou X, Torashima Y, Grikscheit TC. A "living bioreactor" for the production of tissue-engineered small intestine. Methods Mol Biol. 2013;1001:299-309. 13) Eguchi S, Takatsuki M, Soyama A, Torashima Y, Tsuji A, Kuroki T. False positivity for the human immunodeficiency virus antibody after influenza vaccination in a living donor for liver transplantation. Liver Transpl. 2013 Jun;19(6):666. 14) Tanaka T, Takatsuki M, Soyama A, Torashima Y, Kinoshita A, Yamaguchi I, Adachi T, Kitasato A, Kuroki T, Eguchi S. Evaluation of immune function under conversion from Prograf to Advagraf in living donor liver transplantation. Ann Transplant. 2013 Jun 14;18:293-8. 15) Soyama A, Takatsuki M, Adachi T, Kitasato A, Torashima Y, Natsuda K, Tanaka T, Yamaguchi I, Tanaka S, Kinoshita A, Kuroki T, Eguchi S. A hybrid method of laparoscopic-assisted open liver resection through a short upper midline laparotomy can be applied for all types of hepatectomies. Surg Endosc. 2014 Jan;28(1):203-11. 16) Fujita F, Torashima Y, Kuroki T, Eguchi S. The risk factors and predictive factors for anastomotic leakage after resection for colorectal cancer: reappraisal of the literature. Surg Today. 2014 Sep;44(9):1595-602. 17) Yoneda A, Taniguchi K, Torashima Y, Susumu S, Kanetaka K, Kuroki T, Eguchi S. The detection of gastric cancer cells in intraoperative peritoneal lavage using the reverse transcription--loop-mediated isothermal amplification method. J Surg Res. 2014 Mar;187(1):e1-6. 5 18) Natsuda K, Soyama A, Takatsuki M, Yamaguchi T, Torashima Y, Kitasato A, Adachi T, Kuroki T, Ichikawa T, Nakao K, Eguchi S. Acoustic radiation force impulse elastography for liver disease staging in human immunodeficiency virus and hepatitis C virus co-infection. Nihon Shokakibyo Gakkai Zasshi. 2014 Apr;111(4):737-42. 19) To the editor: is the serum level of reactive oxygen metabolites appropriate for evaluating short-term surgical stress of patients undergoing colectomy? Fujita F, Torashima Y, Takatsuki M, Kuroki T, Eguchi S. Int Surg. 2015 Apr;100(4):770-2. 20) Tobita M, Konomi K, Torashima Y, Kimura K, Taoka M, Kaminota M Japan's challenges of translational regenerative medicine: Act on the safety of regenerative medicine Regen Therapy. 4,:78-81, 2016 21) Baimakhanov Z , Torashima Y, Soyama A, Inoue Y, Sakai Y, Takatsuki M, Fujita F, Kanetaka K, Kuroki T, Eguchi S Generating tissue-engineered intestinal epithelium from cultured Lgr5 stem cells in vivo Author links open overlay panel Regen Therapy. 5,:46-48, 2016 PUBLICATIONS: ABSTRACTS / PRESENTATIONS 1) Torashima Y, Tajima Y, Matsuzaki S, Kuroki T, Furui J, Kanematsu T. The Denver shunt is effective against obstinate chylous ascites. : report of a case. 38th Annual Meeting of Kyushu Surgical Society, Oita, June 1, 2001. 2) Torashima Y, Maeda S, Minami S, Furui J, Kanematsu T. A Case of huge thyroid tumor that underwent VANS. 26th Japan College of Surgeons, Tokyo, July 28, 2001. 3) Torashima Y, Taniguchi K, Yamaguchi J, Fujioka H, Nakamichi M, Izawa K. Surgery for ileal mesenteric lymphangioma during pregnancy: report of a case. 39th Annual Meeting of Kyushu Surgical Society. Okinawa, July 1, 2002. 4) Torashima Y, Taniguchi K, Yamaguchi J, Fujioka H, Izawa K. A case of carcinoid of the appendix. 80th Annual Meeting of Japanese Society of Gastroenterology (Kyusyu section), Saga, Nov. 29, 2002. 5) Torashima Y, Taniguchi K, Yamaguchi J, Fujioka H, Izawa K. A case of rectal cancer with the paraneoplastic syndrome. 234th Nagasaki Surgical Meeting, Nagasaki, Mar. 15, 2003. 6) Torashima Y, Kawashita Y, Kamohara Y, Kisikawa H. A case of hemangioma which was difficult to differentiate from HCC. 19th Annual Meeting for Nagasaki HBP Conference, July 12, 2003 7) Torashima Y, Okudaira S, Kisikawa H. A case of vesico-cutaneous fistula because of sigmoid diverticulum. 82nd Annual Meeting of Japanese Society of Gastroenterology Kyushu branch, Nagasaki, Nov. 22, 2003. 6 8) Torashima Y, Okudaira S, Kisikawa H. A case of gastric cancer with metastatic liver tumors that was offered a long-term survival by combined modality therapy. 235th Nagasaki Surgical Meeting, Nagasaki, Mar. 6, 2004. 9) Torashima Y, Okudaira S, Kisikawa H. Two cases of gastric cancer with metastatic liver tumors that was offered a long-term survival. 59th Annual Meeting of Japanese Society of Gastroenterological Surgery, July 23, 2004. 10) Torashima Y, Fujita H, Nagata Y, Enjoji A, Maeda S, Kanematsu T, Tanaka K. The technique of esophageal reconstruction for the esophageal cancer with gastric cancer. 236th Nagasaki Surgical Meeting, Nagasaki, Mar. 26, 2005. 11) Torashima Y, Uezono Y, Enjoji A, Kanematsu T, Taniyama K. Characterization of GABA B Receptor in the Human Esophagus and Human Stomach. 47th Annual Meeting for Japan Society of Smooth Muscle Research, Sendai, July 8, 2005. 12) Torashima Y, Uezono Y, Kanaide M, Enjoji A, Kanematsu T, Taniyama K. Characterization of GABA B Receptor in the Human Esophagus and Human Stomach. 2nd Annual Meeting of the Japanese Gastroenterological Association, Tokyo, Feb. 12, 2006. 13) Torashima Y, Uezono Y, Kanaide M, Enjoji A, Kanematsu T, Taniyama K.