Table S2. Protein identities included in PEA immunoassay No. Protein Biomarkers analyzed by PEA 1 Aminopeptidase N (AP-N) 2 Azurocidin (AZU1 3 Bleomycin hydrolase (BLM hydrolase) 4 C-C motif chemokine 15 (CCL15) 5 C-C motif chemokine 16 (CCL16) 6 C-C motif chemokine 24 (CCL24) 7 C-X-C motif chemokine 16 (CXCL16) 8 Cadherin-5 (CDH5) 9 Carboxypeptidase A1 (CPA1) 10 Carboxypeptidase B (CPB1) 11 Caspase-3 (CASP-3) 12 Cathepsin D (CTSD) 13 Cathepsin Z (CTSZ) 14 CD166 antigen (ALCAM) 15 Chitinase-3-like protein 1 (CHI3L1) 16 Chitotriosidase-1 (CHIT1) 17 Collagen alpha-1(I) chain (COL1A1) 18 Complement component C1q receptor (CD93) 19 Contactin-1 (CNTN1) 20 Cystatin-B (CSTB) 21 E-selectin (SELE) 22 Elafin (PI3) 23 Ephrin type-B receptor 4 (EPHB4) 24 Epidermal growth factor receptor (EGFR ) 25 Epithelial cell adhesion molecule (Ep-CAM) 26 Fatty acid-binding protein, adipocyte (FABP4) 27 Galectin-3 (Gal-3) 28 Galectin-4 (Gal-4) 29 Granulins (GRN) 30 Growth/differentiation factor 15 (GDF-15) 31 Insulin-like growth factor-binding protein 1 (IGFBP-1) 32 Insulin-like growth factor-binding protein 2 (IGFBP-2) 33 Insulin-like growth factor-binding protein 7 (IGFBP-7) 34 Integrin beta-2 (ITGB2) 35 Intercellular adhesion molecule 2 (ICAM-2) 36 Interleukin-1 receptor type 1 (IL-1RT1) 37 Interleukin-1 receptor type 2 (IL-1RT2) 38 Interleukin-17 receptor A (IL-17RA) 39 Interleukin-18-binding protein (IL-18BP) 40 Interleukin-2 receptor subunit alpha (IL2-RA) 41 Interleukin-6 receptor subunit alpha (IL-6RA) 42 Junctional adhesion molecule A (JAM-A) 43 Kallikrein-6 (KLK6 ) 44 Low-density lipoprotein receptor (LDL receptor) 45 Lymphotoxin-beta receptor (LTBR) 46 Matrix extracellular phosphoglycoprotein (MEPE) 47 Matrix metalloproteinase-2 (MMP-2) 48 Matrix metalloproteinase-3 (MMP-3) 49 Matrix metalloproteinase-9 (MMP-9) 50 Metalloproteinase inhibitor 4 (TIMP4) 51 Monocyte chemotactic protein 1 (MCP-1) 52 Myeloblastin (PRTN3) 53 Myeloperoxidase (MPO) 54 Myoglobin (MB) 55 N-terminal prohormone brain natriuretic peptide (NT-proBNP) 56 Neurogenic locus notch homolog protein 3 (Notch 3) 57 Osteopontin (OPN) 58 Osteoprotegerin (OPG) 59 P-selectin (SELP) 60 Paraoxonase (PON3) 61 Peptidoglycan recognition protein 1 (PGLYRP1) 62 Perlecan (PLC) 63 Plasminogen activator inhibitor 1 (PAI) 64 Platelet endothelial cell adhesion molecule (PECAM-1) 65 Platelet-derived growth factor subunit A (PDGF subunit A) 66 Proprotein convertase subtilisin/kexin type 9 (PCSK9) 67 Protein delta homolog 1 (DLK-1) 68 Pulmonary surfactant-associated protein D (PSP-D) 69 Resistin (RETN) 70 Retinoic acid receptor responder protein 2 (RARRES2) 71 Scavenger receptor cysteine-rich type 1 protein M130 (CD163) 72 Secretoglobin family 3A member 2 (SCGB3A2) 73 Spondin-1 (SPON1) 74 ST2 protein (ST2) 75 Tartrate-resistant acid phosphatase type 5 (TR-AP) 76 Tissue factor pathway inhibitor (TFPI) 77 Tissue-type plasminogen activator (t-PA) 78 Transferrin receptor protein 1 (TR) 79 Trefoil factor 3 (TFF3) 80 Trem-like transcript 2 protein (TLT-2) 81 Tumor necrosis factor ligand superfamily member 13B (TNFSF13B) 82 Tumor necrosis factor receptor 1 (TNF-R1) 83 Tumor necrosis factor receptor 2 (TNF-R2) 84 TNFR superfamily member 10C (TNFRSF10C) 85 Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) 86 Tumor necrosis factor receptor superfamily member 6 (FAS ) 87 Tyrosine-protein kinase receptor UFO (AXL) 88 Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS-1) 89 Urokinase plasminogen activator surface receptor (U-PAR) 90 Urokinase-type plasminogen activator (uPA) 91 von Willebrand factor (vWF) 92 5'-nucleotidase (5'-NT) 93 ADAM-TS 15 94 Alpha-taxilin (TXLNA) 95 Amphiregulin (AREG) 96 Annexin A1 (ANXA1) 97 C-type lectin domain family 4 member K (CD207) 98 C-X-C motif chemokine 13 (CXCL13 ) 99 Carbonic anhydrase IX (CAIX) 100 Carboxypeptidase E (CPE) 101 Carcinoembryonic antigen (CEA) 102 CEACAM1 103 Cathepsin L2 (CTSV) 104 CD160 antigen (CD160) 105 CD27 antigen (CD27) 106 CD48 antigen (CD48) 107 CD70 antigen (CD70) 108 Cornulin (CRNN) 109 Cyclin-dependent kinase inhibitor 1 (CDKN1A) 110 Delta-like protein 1 (DLL1) 111 ADAM8 112 Endothelial cell-specific molecule 1 (ESM-1) 113 Ephrin type-A receptor 2 (EPHA2) 114 Fas antigen ligand (FasL) 115 FAS-associated death domain protein (FADD) 116 Fc receptor-like B (FCRLB) 117 Fibroblast growth factor-binding protein 1 (FGF-BP1) 118 Folate receptor alpha (FR-alpha) 119 Folate receptor gamma (FR-gamma) 120 Furin (FUR) 121 Galectin-1 (Gal-1) 122 Glypican-1 (GPC1) 123 Granzyme B (GZMB) 124 Granzyme H (GZMH) 125 Hepatocyte growth factor (HGF) 126 ICOS ligand (ICOSLG) 127 Insulin-like growth factor 1 receptor (IGF1R) 128 Integrin alpha-V (ITGAV) 129 Integrin beta-5 (ITGB5) 130 Interferon gamma receptor 1 (IFN-gamma-R1) 131 Interleukin-6 (IL6) 132 Kallikrein-11 (hK11) 133 Kallikrein-13 (KLK13) 134 Kallikrein-14 (hK14) 135 Kallikrein-8 (hK8) 136 Ly6/PLAUR domain-containing protein 3 (LYPD3) 137 Melanoma-derived growth regulatory protein (MIA) 138 Mesothelin (MSLN) 139 Methionine aminopeptidase 2 (MetAP 2) 140 MHC class I polypeptide-related sequence A/B (MIC-A/B) 141 Midkine (MK) 142 Mothers against decapentaplegic homolog 5 (MAD homolog 5) 143 Mucin-16 (MUC-16) 144 Nectin-4 (PVRL4) 145 Pancreatic prohormone (PPY) 146 Podocalyxin (PODXL) 147 Pro-epidermal growth factor (EGF) 148 Protein CYR61 (CYR61) 149 Protein S100-A11 (S100A11) 150 Protein S100-A4 (S100A4) 151 Proto-oncogene tyrosine-protein kinase receptor Ret (RET) 152 R-spondin-3 (RSPO3) 153 Receptor tyrosine-protein kinase erbB-2 (ErbB2/HER2) 154 Receptor tyrosine-protein kinase erbB-3 (ErbB3/HER3) 155 Receptor tyrosine-protein kinase erbB-4 (ErbB4/HER4) 156 Secretory carrier-associated membrane protein 3 (SCAMP3) 157 Seizure 6-like protein (SEZ6L) 158 SPARC (SPARC) 159 Stem cell factor (SCF) 160 Syndecan-1 (SYND1) 161 T-cell leukemia / lymphoma protein 1A (TCL1A) 162 T-lymphocyte surface antigen Ly-9 (LY9) 163 TGF-beta receptor type-2 (TGFR-2) 164 Tissue factor pathway inhibitor 2 (TFPI-2) 165 TNF-related apoptosis-inducing ligand (TRAIL) 166 Toll-like receptor 3 (TLR3) 167 Transforming growth factor alpha (TGF-alpha) 168 Transmembrane glycoprotein NMB (GPNMB) 169 Tumor necrosis factor ligand superfamily member 13 (TNFSF13) 170 Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) 171 Tumor necrosis factor receptor superfamily member 4 (TNFRSF4 ) 172 Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) 173 Tyrosine-protein kinase ABL1 (ABL1) 174 Tyrosine-protein kinase Lyn (LYN) 175 Vascular endothelial growth factor A (VEGF-A) 176 Vascular endothelial growth factor receptor 2 (VEGFR-2) 177 Vascular endothelial growth factor receptor 3 (VEGFR-3) 178 VEGF-co regulated chemokine 1 (CXCL17) 179 Vimentin (VIM) 180 WAP four-disulfide core domain protein 2 (WFDC2) 181 Wnt inhibitory factor 1 (WIF-1) 182 WNT1-inducible-signaling pathway protein 1 (WISP-1) 183 Xaa-Pro aminopeptidase 2 (XPNPEP2) .