Volume Number 116 3 March 2020 Brazilian Society of Cardiology ISSN-0066-782X Controls Rheumatic mitral valves Figure 1, page 406 The Method and the Mantra Chief Editor Carlos Rochitte Impact of COVID-19 on cardiovascular diseases Internacional Coeditor Prognosis of B-lines in heart failure João Lima Hemophagocytic syndrome and heart failure Editors Alexandre Colafranceschi Rheumatic mitral valve disease Gláucia Moraes Ieda Jatene mir-34a and mir-125b on cardiac cell death Marcio Bittencourt Marina Okoshi Cardiovascular Risk in the Brazilian Population Mauricio Scanavacca Nuno Bettencourt Paulo Jardim Cardiac Rehabilitation and Mean Platelet Volume Pedro Lemos Ricardo Stein Infliximab therapy in resistant hypertension Ruhong Jiang Tiago Senra Validation of ECG Algorithm for VT Vitor Guerra Gensini, thrombus burden and SYNTAX in no-reflow JOURNAL OF BRAZILIAN SOCIETY OF CARDIOLOGY - Published since 1943 Contents Editorial The Method and the Mantra Andre d’Avila and Marcos F. Vidal Melo .....................................................................................................................................................................page 367 Original Article Reduction in Hospitalization and Increase in Mortality Due to Cardiovascular Diseases during the COVID-19 Pandemic in Brazil Paulo Garcia Normando, José de Arimatéia Araujo-Filho, Gabriela de Alcântara Fonseca, Rodrigo Elton Ferreira Rodrigues, Victor Agripino Oliveira, Ludhmila Abrahão Hajjar, André Luiz Cerqueira Almeida, Edimar Alcides Bocchi,Vera Maria Cury Salemi,Marcelo Melo .....................................................................................................................................................................page 371 Short Editorial Avoidable Cardiovascular Events: A Serious Side Effect of the COVID-19 Pandemic Fernando H. Y. Cesena .....................................................................................................................................................................page 381 Original Article Prognostic Value of Lung Ultrasound for Clinical Outcomes in Heart Failure Patients: A Systematic Review and Meta-Analysis Yushu Wang, Di Shi, Fuqiang Liu, Ping Xu, Min Ma .....................................................................................................................................................................page 383 Short Editorial Is There a Role for Lung Ultrasonography in the Prognosis of Heart Failure Patients? Mônica Samuel Avila e Deborah De Sá Pereira Belfort .....................................................................................................................................................................page 393 Original Article Mortal İnteraction Between Hemophagocytic Syndrome and Newly Developed Heart Fail Devrim Bozkurt, Sukriye Miray Kilincer Bozgul, Omer Emgin, Osman Butun, Timur Kose, Evrim Simsek, Mine Hekimgil, Salih Kilic .....................................................................................................................................................................page 395 Arquivos Brasileiros de Cardiologia - Volume 116, Nº 3, March 2021 Short Editorial Hyperinflammatory Syndrome as a Cardiac Injury Mechanism Silvia Moreira Ayub-Ferreira e Maria Tereza Sampaio de Sousa Lira .....................................................................................................................................................................page 402 Original Article Histopathological Characterization of Mitral Valvular Lesions from Patients with Rheumatic Heart Disease Nayana F. A. Gomes,Marcelo A. Pascoal-Xavier, Livia S. A. Passos, Thiago Mendonça Nunes Paula, João Marcelo de Souza Aguiar, Felipe Vieira Guarçoni, Maria Cecília Landim Nassif, Claudio Leo Gelape,Renato Braulio, Paulo Henrique N. Costa, Luiz Guilherme Passaglia, Raquel Braga Martins, Walderez O. Dutra, Maria Carmo P. Nunes .....................................................................................................................................................................page 404 Short Editorial Histopathological Characterization of Mitral Valvular Lesions in Patients With Rheumatic Heart Disease: Is Inflammation Also to Blame for Chronic Valvular Heart Disease Progression? Vitor Emer Egypto Rosa .....................................................................................................................................................................page 413 Original Article Inhibiting Glucose Metabolism By miR-34a and miR-125b Protects Against Hyperglycemia- Induced Cardiomyocyte Cell Death Chao-rui Xu and Qiu-ju Fang .....................................................................................................................................................................page 415 Original Article Cardiovascular Risk Estimates in Ten Years in the Brazilian Population, a Population-Based Study Deborah Carvalho Malta, Pedro Cisalpino Pinheiro, Renato Azeredo Teixeira, Isis Eloah Machado, Filipe Malta dos Santos, Antônio Luiz Pinho Ribeiro .....................................................................................................................................................................page 423 Short Editorial “Know the Enemy and Know Yourself”. Cardiovascular Risk in the National Health Survey Itamar S. Santos ......................................................................................................................................................................................page 432 Original Article Exercise-Based Cardiac Rehabilitation Has a Strong Relationship with Mean Platelet Volume Reduction İsmet Durmuş, Ezgi Kalaycıoğlu, Mustafa Çetin, Hanife Baykal Şahin, Tuncay Kırış ......................................................................................................................................................................................page 434 Arquivos Brasileiros de Cardiologia - Volume 116, Nº 3, March 2021 Short Editorial Reduction in Platelet Activation: A Potential Mechanistic Link between Regular Exercise and Its Benefits for Coronary Artery Disease Christina Grüne de Souza e Silva ......................................................................................................................................................................................page 441 Original Article Effects of Anti-TNF alpha Therapy on Blood Pressure in Resistant Hypertensive Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study Ana Paula de Faria, Alessandra M. V. Ritter, Arthur Santa-Catharina, Débora P. Souza, Estephania P. Naseri, Manoel B. Bertolo, Mariana Rodrigues Pioli, Caio C. Carvalho, Rodrigo Modolo, Heitor Moreno ......................................................................................................................................................................................page 443 Short Editorial New Perspectives in the Treatment of Hypertension Heno F. Lopes ......................................................................................................................................................................................page 452 Original Article Validation of a Simple Electrocardiographic Algorithm for Detection of Ventricular Tachycardia Francisco Santos Neto, Cristiano F. Pisani, Francisco Carlos da Costa Darrieux, Celia M. F. Cirino, Denise Tessariol Hachul, Astrid M. Santos, Andrés Ricardo Pérez-Riera, Raimundo Barbosa-Barros, Mauricio Scanavacca ......................................................................................................................................................................................page 454 Short Editorial Simplified Algorithm for Differential Diagnosis of Tachycardias with Wide QRS. Is this the Best Way to Train Young Doctors? Enrique Indalécio Pachón Mateo ......................................................................................................................................................................................page 464 Original Article Gensini Score and Thrombus Burden Add Predictive Value to the SYNTAX Score in Detecting No-Reflow after Myocardial Infarction Luís Carlos V. Matos, Luiz Sergio Carvalho,Rodrigo Modolo, Simone Santos,José Carlos Quinaglia e Silva,Osório Luis Rangel de Almeida, Andrei C. Sposito ......................................................................................................................................................................................page 466 Short Editorial Angiographic Scores in Prediction of No-Reflow, Myocardial Injury May not end with Reperfusion Adriano Ossuna Tamazato,Thais Chang Valente Tamazato, Cristiano Guedes Bezerra ......................................................................................................................................................................................page 473 Arquivos Brasileiros de Cardiologia - Volume 116, Nº 3, March 2021 Original Article Arterial Stiffness Changes in Severe Aortic Stenosis Patients Submitted to Valve Replacement Surgery Renata Raimundo, Francisca Saraiva, Raquel Moreira, Soraia Moreira, Ana Filipa Ferreira, Rui J. Cerqueira, Mario Jorge Amorim,Paulo Pinho,António Sousa Barros,André P. Lourenço,Adelino Leite-Moreira ......................................................................................................................................................................................page 475 Short Editorial