Supplement Table 1: Genes downregualted by CSA in skin and associated cell types Associated cell types: Symbol resting cells cytokine activation T cell activation Description PITPNB _ T cell+PBMC act. phosphatidylinositol transfer protein, beta IDH3A _ T cell+PBMC act. isocitrate dehydrogenase 3 (NAD+) alpha RCC1 _ T cell+PBMC act. regulator of chromosome condensation 1 BZW1 _ T cell+PBMC act. basic leucine zipper and W2 domains 1 SYNCRIP _ T cell+PBMC act. synaptotagmin binding, cytoplasmic RNA interacting protein CXCL1 _ IL-17 *, TNF PBMC act. chemokine (C-X-C motif) ligand 1 CXCL11 _ IFN PBMC act. chemokine (C-X-C motif) ligand 11 CXCL9 _ IFN PBMC act. chemokine (C-X-C motif) ligand 9 CXCL10 _ IFN PBMC act. chemokine (C-X-C motif) ligand 10 MMP12 _ PBMC act. matrix metallopeptidase 12 (macrophage elastase) TGM3 _ PBMC act. transglutaminase 3 CCNE2 _ PBMC act. cyclin E2 RRM2 _ PBMC act. ribonucleotide reductase M2 polypeptide DHFR _ PBMC act. dihydrofolate reductase RABGGTA _ TNF Rab geranylgeranyltransferase, alpha subunit DEFB4 _ IFN defensin, beta 4 TAP2 _ IFN transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) LCN2 _ IL-17* lipocalin 2 (oncogene 24p3) TRIP13 common Fb+KC T cell+PBMC act. thyroid hormone receptor interactor 13 RPP40 common Fb+KC T cell+PBMC act. ribonuclease P 40kDa subunit TYMS common Fb+KC PBMC act. thymidylate synthetase CDC6 common Fb+KC PBMC act. cell division cycle 6 homolog (S. cerevisiae) TOP2A common Fb+KC PBMC act. topoisomerase (DNA) II alpha 170kDa CDC2 common Fb+KC PBMC act. cell division cycle 2, G1 to S and G2 to M CCNA2 common Fb+KC PBMC act. cyclin A2 CCNB1 common Fb+KC PBMC act. cyclin B1 PHLDA2 common Fb+KC PBMC act. pleckstrin homology-like domain, family A, member 2 ZWINT common Fb+KC PBMC act. ZW10 interactor KIAA0101 common Fb+KC PBMC act. KIAA0101 KIF11 common Fb+KC PBMC act. kinesin family member 11 TK1 common Fb+KC PBMC act. thymidine kinase 1, soluble MCM4 common Fb+KC PBMC act. MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) OSMR common Fb+KC IFN KC+IFN oncostatin M receptor SERPINB7 common Fb+KC serpin peptidase inhibitor, clade B (ovalbumin), member 7 ALDH1A3 common Fb+KC aldehyde dehydrogenase 1 family, member A3 CASP7 common iDC+mDC TNF PBMC act. caspase 7, apoptosis-related cysteine peptidase NOS2A common iDC+mDC nitric oxide synthase 2A (inducible, hepatocytes) BCL2A1 common myeloid T cell+PBMC act. BCL2-related protein A1 NP common myeloid T cell+PBMC act. nucleoside phosphorylase ECGF1 common myeloid TNF, IFN PBMC act. endothelial cell growth factor 1 (platelet-derived) IL1B common myeloid IL-17^, TNF PBMC act. interleukin 1, beta MMP9 common myeloid TNF PBMC act. matrix metallopeptidase 9 SOD2 common myeloid TNF PBMC act. superoxide dismutase 2, mitochondrial PLAUR common myeloid IFN PBMC act. plasminogen activator, urokinase receptor CTSL1 common myeloid IFN PBMC act. cathepsin L1 ALAS1 common myeloid TNF PBMC act. aminolevulinate, delta-, synthase 1 CCL18 common myeloid PBMC act. chemokine (C-C motif) ligand 18 PTPRE common myeloid PBMC act. protein tyrosine phosphatase, receptor type, E GM2A common myeloid PBMC act. GM2 ganglioside activator LILRB4 common myeloid PBMC act. leukocyte immunoglobulin-like receptor, subfamily B UPP1 common myeloid PBMC act. uridine phosphorylase 1 GK common myeloid PBMC act. glycerol kinase GK3P common myeloid PBMC act. glycerol kinase 3 pseudogene KYNU common myeloid PBMC act. kynureninase (L-kynurenine hydrolase) GPX3 common myeloid PBMC act. glutathione peroxidase 3 (plasma) CTSC common myeloid TNF, IFN cathepsin C LYN common myeloid TNF, IFN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog CXCL2 common myeloid TNF, IFN chemokine (C-X-C motif) ligand 2 MALT1 common myeloid IFN mucosa associated lymphoid tissue lymphoma translocation gene 1 CASP1 common myeloid IFN caspase 1, apoptosis-related cysteine peptidase ACP5 common myeloid IFN acid phosphatase 5, tartrate resistant CD14 common myeloid CD14 molecule SERPINA1 common myeloid serpin peptidase inhibitor, clade A FCER1G common myeloid Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide CYBB common myeloid cytochrome b-245, beta polypeptide AMPD3 common myeloid adenosine monophosphate deaminase (isoform E) C1QB common myeloid complement component 1, q subcomponent, B chain MYO5A common myeloid myosin VA (heavy chain 12, myoxin) S100A9 common myeloid S100 calcium binding protein A9 LPHN2 Fb latrophilin 2 PLAT Fb PBMC act. plasminogen activator, tissue HSPA4 housekeeping T cell+PBMC act. heat shock 70kDa protein 4 housekeeping T cell+PBMC act. MRPS12 housekeeping T cell+PBMC act. mitochondrial ribosomal protein S12 UCK2 housekeeping T cell+PBMC act. uridine-cytidine kinase 2 AHCY housekeeping T cell+PBMC act. S-adenosylhomocysteine hydrolase TSR1 housekeeping T cell+PBMC act. TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) YKT6 housekeeping T cell+PBMC act. YKT6 v-SNARE homolog (S. cerevisiae) CD47 housekeeping IFN T cell act. CD47 molecule CEBPG housekeeping T cell act. CCAAT/enhancer binding protein (C/EBP), gamma PGK1 housekeeping IFN PBMC act. phosphoglycerate kinase 1 WARS housekeeping IFN PBMC act. tryptophanyl-tRNA synthetase APOL1 housekeeping IFN PBMC act. apolipoprotein L, 1 CSTB housekeeping PBMC act. cystatin B (stefin B) CCNE1 housekeeping PBMC act. cyclin E1 PCNA housekeeping proliferating cell nuclear antigen CHI3L2 housekeeping chitinase 3-like 2 VRK2 housekeeping vaccinia related kinase 2 SSR1 housekeeping signal sequence receptor, alpha DPAGT1 housekeeping dolichyl-phosphate (UDP-N-acetylglucosamine) KLK13 housekeeping kallikrein-related peptidase 13 SLC23A2 housekeeping solute carrier family 23 (nucleobase transporters), member 2 SLC25A13 housekeeping solute carrier family 25, member 13 (citrin) DUSP3 housekeeping dual specificity phosphatase 3 HIPK3 housekeeping homeodomain interacting protein kinase 3 PDXK iDC T cell+PBMC act. pyridoxal (pyridoxine, vitamin B6) kinase CD53 iDC CD53 molecule IL1RN iDC PBMC act. interleukin 1 receptor antagonist HMGCS1 KC T cell+PBMC act. 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) SLC16A1 KC T cell+PBMC act. solute carrier family 16, member 1 FEN1 KC T cell+PBMC act. flap structure-specific endonuclease 1 EVA1 KC T cell act. epithelial V-like antigen 1 MCM2 KC PBMC act. MCM2 minichromosome maintenance deficient 2, mitotin KIF2C KC PBMC act. kinesin family member 2C PTTG1 KC PBMC act. pituitary tumor-transforming 1 MALL KC IFN mal, T-cell differentiation protein-like XDH KC IFN xanthine dehydrogenase VSNL1 KC IFN visinin-like 1 SERPINB3 KC serpin peptidase inhibitor, clade B (ovalbumin), member 3 EPHA2 KC EPH receptor A2 CDH3 KC cadherin 3, type 1, P-cadherin (placental) S100A2 KC S100 calcium binding protein A2 ABCA12 KC ATP-binding cassette, sub-family A (ABC1), member 12 CKMT1B KC creatine kinase, mitochondrial 1B SLPI KC secretory leukocyte peptidase inhibitor PKP1 KC plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) ATP12A KC ATPase, H+/K+ transporting, nongastric, alpha polypeptide PRSS1 KC protease, serine, 1 (trypsin 1) ALOX12B KC arachidonate 12-lipoxygenase, 12R type C14orf147 KC chromosome 14 open reading frame 147 SPRR1A KC small proline-rich protein 1A DSG3 KC desmoglein 3 (pemphigus vulgaris antigen) KRT17 KC keratin 17 AASS KC aminoadipate-semialdehyde synthase TGM1 KC transglutaminase 1 ETHE1 KC ethylmalonic encephalopathy 1 KLK10 KC kallikrein-related peptidase 10 SPRR1B KC small proline-rich protein 1B (cornifin) KRT16 KC keratin 16 (focal non-epidermolytic palmoplantar keratoderma) AKR1B10 KC aldo-keto reductase family 1, member B10 (aldose reductase) MDFI KC MyoD family inhibitor FGFBP1 KC fibroblast growth factor binding protein 1 KRT6C KC keratin 6C DSC2 KC desmocollin 2 PRSS3 KC protease, serine, 3 (mesotrypsin) PI3 KC peptidase inhibitor 3, skin-derived (SKALP) SPRR2C KC small proline-rich protein 2C SPRR2D KC small proline-rich protein 2D CFLAR leukocytes TNF, IFN T cell+PBMC act. CASP8 and FADD-like apoptosis regulator CCL20 leukocytes TNF T cell+PBMC act. chemokine (C-C motif) ligand 20 PBEF1 leukocytes T cell+PBMC act. pre-B-cell colony enhancing factor 1 CCL4 leukocytes T cell+PBMC act. chemokine (C-C motif) ligand 4 GZMB leukocytes T cell+PBMC act. granzyme B LCP2 leukocytes T cell+PBMC act. lymphocyte cytosolic protein 2 PSMB10 leukocytes TNF, IFN PBMC act. proteasome (prosome, macropain) subunit, beta type, 10 IRF1 leukocytes TNF, IFN PBMC act. interferon regulatory factor 1 IL8 leukocytes TNF PBMC act. interleukin 8 GBP1 leukocytes IFN PBMC act. guanylate binding protein 1, interferon-inducible, 67kDa RAB27A leukocytes IFN PBMC act. RAB27A, member RAS oncogene family SUB1 leukocytes PBMC act. SUB1 homolog (S. cerevisiae) RGS1 leukocytes PBMC act. regulator of G-protein signalling 1 KIF2A leukocytes PBMC act. kinesin heavy chain member 2A STAT3 leukocytes IFN signal transducer and activator of transcription 3 ZFP36 leukocytes IFN zinc finger protein 36, C3H type, homolog (mouse) IL7R leukocytes interleukin 7 receptor PTPN22 leukocytes protein tyrosine phosphatase, non-receptor type 22 (lymphoid) CD3D leukocytes CD3d molecule, delta (CD3-TCR complex) C1orf9 leukocytes chromosome 1 open reading frame 9 STK17A leukocytes serine/threonine kinase 17a AMD1 macrophages T-cell+PBMCact adenosylmethionine decarboxylase 1 AGPS macrophages T-cell+PBMCact alkylglycerone phosphate synthase HK2 macrophages T-cell+PBMCact hexokinase 2 RALA macrophages IFN PBMCact,KC+IFN v-ral simian leukemia viral oncogene homolog A (ras related) RAC2 macrophages PBMCact ras-related C3 botulinum toxin substrate 2 RAB31 macrophages RAB31, member RAS oncogene family ADAMDEC1 macrophages ADAM-like, decysin 1 CD83 mDC TNF T cell+PBMC act. CD83 molecule CCL3 mDC T cell+PBMC act. chemokine (C-C motif) ligand 3 MPHOSPH6 mDC T cell+PBMC act. M-phase phosphoprotein 6 N4BP1 mDC TNF, IFN PBMCact,KC+TNFand IFN Nedd4 binding protein 1 UBD mDC IFN PBMC act. ubiquitin D IL13RA1 mDC TNF interleukin 13 receptor, alpha 1 CFB mDC IFN complement factor B IL4R mDC IFN interleukin 4 receptor TOP1 monocytes IFN T cell+PBMC act. topoisomerase (DNA) I PTP4A1 monocytes T cell+PBMC act.