Curriculum Vitae Sofia Kasradze, MD CURRENT POSITION Ass. Prof in Neurology – Caucasus International Universiti, Tbilisi, Georgia Director of the LTD “Institute of Neurology and Neuropsychology”, Tbilisi, Georgia President of the Georgian Chapter of the International League Against Epilepsy (ILAE) Expert on problems of Epilepsy of the MoH of Georgia ORCID N 0000-0002-3266-4077 Address: 83/11 Vazha-Pshavela Ave., 0186 Tbilisi, Georgia Tel (Off): (032) 2 912 947 (off) Tel-Mob: +995 599 581 556 E-mail: [email protected] RESEARCH INTERESTS Neurology - Epilepsy, Clinical Electrophysiology/electroencephalography, Sleep disorders Women’s health in women with neurological conditions. IT technologies for management and care systems for chronic neurological conditions (Telemedicine, preventive and informative systems, distance education etc.). ACADEMIC DEGREE /EDUCATION Ass. Prof. in Neurology, Caucasus International University (since 2015) MD Ph.D., Sarajishvili Institute of Neurology and Neurosurgery and Georgian Academy of Sciences, Tbilisi, Georgia (2006) MD Neurologist –in the P. Sarajishvili Institute of Neurology and Neurosurgery (1987-2002) Clinical Ordinate - Post-graduate Course in Neurology/Epileptology, epilepsy Centre at the Sarajishvili Institute of Neurology and Neurosurgery, Tbilisi Georgia (1985-1987) Student of Pediatric faculty, Tbilisi State Medical University, Tbilisi, Georgia (1974-1981) EXPERIENCE IN TEACHING WORK HEAD OF MD PhD THESIS (DEFENDED/ONGOING) Epidemiology of epilepsies in Ajara Region of Georgia (Ongoing, started in 2016) Epidemiological and specific parameters of the Depression and suicide in patients with Epilepsy (Ongoing, started in 2016) EEG-specificity by the menstrual cycles in women with epilepsy (Ongoing, started in 2016) Specificity of sleep disorders in children with genetic generalized epilepsies (Ongoing, started in 2016) Cognitive functions in children exposed to antiepileptic drugs in utero (Defended in 2018) Peculiarities of the Drug-resistant epilepsies and Perspectives of Epilepsy Surgery in Georgia (Defended in 2016) The attitudes and stigma towards people with epilepsy in Georgia (Defended in 2015) Epidemiology of Epilepsies in Georgia (Defended in 2014) INTENSIVE EDUCATIONAL COURSE ON BOUNDARY SPECIALITY ILAE/ILAE-Europe/GLAE Caucasian Summer School on Clinical Epileptology Chair – 9th (2019, Tbilisi), Co- Chair-2nd (2009, Bazaleti), 4th (2012, Lopota), 6th (2014, Bakuriani) and 7th (2016, Tbilisi)(Georgia) (http://www.ilae.org ) Eight-months Intensive teaching course of sub-specialty on Clinical Neurophysiology/ Electroencephalography (Approved by the Georgian MoH in 2016) CONTINUOUS MEDICAL EDUCATION Organizer and board member of the 30th EACD International Conference (May 28-31, 2018, Tbilisi Georgia. www.eacd2018.net/organization/ ) Organizer and Chair of the “GLAE International Conferences Devoted to 65th anniversary of Georgian Clinical Electrophysiology/Electroencephalography” (Tbilisi, Georgia 2013). Organizer and Chair of the Iv. Javakhishvili TSU-Jefferson University “2nd International conferences on New Horizons of Epilepsy” (Tbilisi, Georgia 2014) Organizer and Chair of the TSMU-Jefferson University “1st International conferences on New Horizons of Epilepsy” (Tbilisi, Georgia 2012); Organizer and Chair of the 9th ILAE/ILAE-Europe Caucasian International Summer School on clinical epileptology (2019, in Tbilisi Georgia) Organizer and Co-Chair of the 2nd (2009, Bazaleti, Georgia), 4th (2012, Lopota, Georgia), 6th (2014, Bakuriani, Georgia), 8th (2016, Tbilisi, Georgia) ILAE/ILAE-Europe Caucasian International Summer Schools on clinical epileptology. Organizer and Chair of the“1st ESRS-GSSS teaching Course on Sleep Disorders” (2011, Tbilisi, Georgia http://www.esrs.eu/cms/front_content.php?idcat=125) EDUCATION OF THE BACHELOR’S DEGREE Neurology- (Caucasus International University - since 2015) SCIENTIFIC PROJECTS AND EXPERIENCE IN ACADIMA 1. ECV - Epihunter Clinical Validation – a multicentre study (2019 –2020) (Sub- Investigator) 2. To identify epileptogenic foci and seizure propagation neuronal networks through the Janashia-Lagvilava mathematical method among the individuals with drug-resistant epilepsy – a pilot multicentre study (2019-2021) (PI) 3. Validation of a Georgian version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) (2018-2019) (PI) 4. e-Health technologies for Epilepsy follow-up Management in Georgia (2018-2020) (PI) 5. A multicenter, open-label, long-term extension study to investigate the efficacy and safety of Lacosamide as Adjunctive therapy in pediatric subjects with epilepsy with partial-onset seizures (EP0034)(UCB) (2014 – current)(Sub-Investigator) 6. A multicenter, open-label, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of Lacosamide as Adjunctive therapy in subjects with epilepsy >1month to <4 years of age with partial- onset seizures (SP0967)(UCB)(2015 – 2020)(Sub-Investigator) 7. Phase 3, multicenter, double blind, randomized, placebo controlled, parallel group study to evaluate the efficacy and safety of lacosamide (LCM), as adjunctive therapy in subjects with epilepsy ≥4 years to <17 years of age with partial-onset seizures(SP0969)(UCB)(2015 – 2017)(Sub-Investigator) 8. EpilepCure – German-Georgian Project “Development of diagnosis, treatment, care and research on Epilepsy in Georgia” (2017- 2020)(PI-Georgian Branch) 9. Effectiveness of Selenium in persons with Restless Legs Syndrome – Georgian-Danish Project (2017 -2019)(PI) 10. Epidemiology and risk factors of pharmacoresistant epilepsy in Georgia” (2012-2014) Scientific project of the Shota Rustaveli National Science Foundation (Project number DI/40/8-313/11). 11. Mobile Telemedicine for Georgian Health Care System – a pilot study (2010) [MTM- Geo](Funded by SRDF/GRDF, MAGTICom)(Sub-Investigator). 12. WHO/ ILAE/IBE/SEIN - Demonstration Project – “Epilepsy Management in Primary Health Care Settings in Georgia” (2008-2011)(Sub-Investigator) 13. EURAP – International Registry of Antiepileptic Drugs and Pregnancy (since 2000-ungoing)(Head of Regional Office) DEVELOPMENT OF NATIONAL STATE PROGRAMS 1. National State Program on Pre-surgical Evaluation of People with Drug-resistant epilepsies (Submitted in MoH in 2019) 2. National State Program on providing free anti-seizure medication for people with epilepsy (Approved by the MoH in 2018) 3. National State program “Prevention and Early diagnosis of Developmental delay in Children aged up to 6 years” (Approved by the MoH of Georgia in 2009). 4. National State Program “Epilepsy Management in Primary Health Care Settings” (Approved by the MoH of Georgia in 2005). 5. Development of Patients’ e-Registry and Electronic Medical Records (EMR) as Cost-Effective Management System for Epilepsy (Approved by MoH and NCDC.Ge in 2015) PUBLICATIONS Articles 1. Dugladze T., Bäuerle P., Kasradye S., Lomidye G., et all. Initiating a new national epilepsy surgery program: Experiences gathered in Georgia. Epilepsy Behav. 2020; 111:107259. 2. Silagadze K., Kasradze S., Silagadze T., Lomidze T. Validation of a Georgian version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E). Epilepsy Behav. 2019 Dec;101(Pt A):106587. doi: 10.1016/j.yebeh.2019.106587. 3. Kasradze S., Tatishvili N. Epilepsy Pioneers and Current Educational Programs in Georgia. J Pediatr Epilepsy 2019; 08(01):023-025. DOI: 10.1055/s-0039-1683972. 4. Sleep disturbances associated with restless legs syndrome in the students living in Georgia. Sleep Medicine, December 2019, 64:S240-S241. 5. Japaridze G., Kasradze S., Maisuradze L., Popp R., C.Wetter T.C. A Comprehensive Review of the Restless Legs Syndrome (Review). Georgian Medical News, 2018;12(285):74-81. 6. Zhizhiashvili L., Japaridze G., Lomidze G., Kasradze S. Effect of Levetiracetam on EEG activity and menstrual cycle in women suffering from epilepsy. Neurophysiology, 2018; 50(5):382-88. 7. Kasradze S, Gogatishvili N, Lomidze G, Ediberidze T, Lazariashvili M, Khomeriki K, Mamukadze S, Metreveli M, Gagoshidze T, Tatishvili N, Tomson T. Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia. Epilepsy Behav. 2017 Jan;66:105-112. doi: 10.1016/j.yebeh.2016.10.014. 8. Mosiashvili Zh, Kasradze S, Gagoshidze T. Working Memory Deficit in Patients with Temporal and Frontal Lobe Epilepsy (2017). JSM Brain Science 2(2):2015. 9. Alkhidze M, Lomidze G, Kasradze S, Tsiskaridze A. Characteristics and predictive biomarkers of drug resistant epilepsy - study in Georgia. Neuroimmunol Neuroinflamation 2017;4:191-8. https://doi.org/10.20517/2347- 8659.2017.14 10. Gogatishvili N, Khachapuridze N, Ediberidze T, Lomidze G, Mamukadze Sh, Gagoshidze T, Kasradze S. Aspects of cognitive functioning and autism in children with antiepileptic drugs exposure in utero. Experimental and Clinical medicine 2017; 1:40-43 (Georgian). 11. Silagadze K, Kasradze S. Psychogenic nonepileptic seizures. Therapia 2017; 1(6):12-14 (Georgian) 12. Gogatishvili N, Khachapuridze N, Japaridze G, Kasradze S. Electroencephalographic discharges and epileptic seizures in children with antiepileptic drugs exposure in utero. Experimental and Clinical medicine 2017; 1:72-76 (Georgian). 13. Japaridze G, Kasradze S, Lomidze G, Zhizhiashvili L, Kvernadze D, Geladze K, Beniczky S. Focal EEG features and therapeutic response in patients with juvenile absence and myoclonic epilepsy. Clin Neurophysiol. 2016 Feb;127(2):1182-1187. doi: 10.1016/j.clinph.2015.11.048. 14. Gogatishvili