International GPCR Symposium June 29 (Fri) -30 (Sat) Siran Kaikan, Kyoto University Programme International GPCR Symposium Date and time: Friday, June 29th - Saturday, June 30th, 2018 Venue: Shiran kaikan, Kyoto University, Kyoto University medical school area, Yoshida Konoe-chou, Sakyou-ku, Kyoto, 606-8501, Japan Purpose of the Session: G protein-coupled receptors (GPCRs), also called as seven-transmembrane receptors, are the largest family of membrane receptors in the human genome and consist of approximately 800 receptors. Importantly, about half of which are GPCRs that interact with endogenous ligands and are the targets for many therapeutic drugs currently in use. In addition, because a substantial number of GPCRs still remain orphan, their biological roles and therapeutic potential are of special interests. This WCP2018 satellite symposium is aimed to exchange the newest insights as well as up-to-date overview of GPCR research and discuss the therapeutic potentials. This satellite symposium is organized as an international meeting of the 15th GPCR Conference, which has been held annually in Japan since 2004. We sincerely look forward to seeing you in Kyoto. Chair: Prof. Atsuro Miyata Kagoshima University Vice chair: Prof. Hitoshi Hashimoto Osaka University Auditor: Prof. Seiji Shioda Hoshi University Prof. Kenji Kangawa National Cerebral and Cardiovascular Center Research Institute Committee: Prof. So Iwata Kyoto University Prof. Masayasu Kojima Kurume University Prof. Takeshi Sakurai Tsukuba University Dr. Yutaka Takahashi Kobe University Prof. Masaki Tanaka Kyoto Prefectual University of Medicine Prof. Kazuwa Nakao Kyoto University Dr. Mikiya Miyazato National Cerebral and Cardiovascular Center Research Institute Dr. Mayumi Furuya Kyoto University Dr. Makiko Suwa Aoyama Gakuin University Prof. Toshihiko Yada Jichi Medical University Prof. Masamitsu Nakazato University of Miyazaki Secretary General: Dr. Yuki Kambe Kagoshima University 1 Venue Shiran Kaikan Stage Oral presentation Inamori Hall Poster Registration desk Gala dinner Yamauchi Hall From Kansai International Airport to Kyoto Kyoto city map Local map 2 For chairpersons and speakers For Chairpersons Please take the next chairperson’s seat at least 15 minutes before the beginning of your session. For Symposists and Oral Presenters Presenters are asked to bring your own laptop PC. The types of connecters available are a D-sub 15 pin (mini) and an HDMI (type A) only. Please bring your own connecter in case your PC does not accept the D-sub 15 pin (mini) or HDMI (type A) connecter. The resolution of the projection screen is XGA (1024 ×768 pixels). Be sure to disable a screensaver and a power-saving mode prior to your presentation. For presenters who want to use PC in the presentation room (Windows PC only), save your presentation data on a USB flash drive, register it at the Operation Desk no later than 60 minutes prior to your presentation. Please visit the Operation Desk located inside the Inamori Hall, no later than 30 minutes prior to your presentation in order to check the connection and operation. Please take the next speaker’s seat during the presentation up to 15 minutes prior to your own presentation. For Poster Presenters Posting and removal times are scheduled as shown below. Note that any posters remaining past the removal time will be disposed of by the Secretariat. The size of panel is 160 * 90 cm. The Presentation number will be provided in advance. Posting June 29 (Fri) 12:30 - 14:30 Presentation June 29 (Fri) 16:30 - 17:30 Removal June 30 (Sat) 12:00 - 13:30 3 Programme Day 1, Jun/29/2018 (Fri) 12:00 - 12:50 Registration 12:50 - 13:00 Opening remark 13:00 - 14:30 Session 1. Historical comments on GPCR by Japanese pioneers Chair: Seiji Shioda (Hoshi University) Chair: Mayumi Furuya (Kyoto University) 1. Dynamic control of glutamatergic transmission via distinct neurotransmitter-receptor interactions Shigetada Nakanishi SUNTORY Foundation for Life Sciences, Bioorganic Research Institute 2. Personal Memories of Biochemical Studies on G Protein-Coupled Receptors Tatsuya Haga Tokyo University Medical School 3. GPCR biology of lipid ligands Takao Shimizu Lipid Signaling Project, National Center for Global Health and Medicine, Department of Lipidomics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan 14:30 - 14:50 Coffee break 14:50 - 16:20 Session 2. New technologies for GPCRs Chair: Masayasu Kojima (Kurume University) Chair: Takanori Ida (University of Miyazaki) 1. The G protein-coupled receptor database, GPCRdb David E. Gloriam Department of Drug Design and Pharmacology, University of Copenhagen Denmark 2. Fluorescence and bioluminescence approaches to study ligand binding to GPCRs and RTKs Stephen J Hill School of Life Sciences, University of Nottingham, Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UK 3. Split-luciferase-based G protein biosensors Francois Marie Ngako Kadji Graduate School of Pharmaceutical Sciences, Tohoku University 4 Programme 16:30 - 17:30 Poster session 17:40 - 18:40 Plenary Lecture 1 Chair: Yumiko Saito (Hiroshima University) Orphan GPCRs history Olivier Civelli Department of Pharmacology, University of California, Irvine, USA 19:00 - Gala dinner 5 Programme Day 2, Jun/30/2018 (Sat) 9:00 - 10:30 Session 3. 3D Structure of GPCRs Chair: Hitoshi Hashimoto (Osaka University) Chair: Yosuke Toyoda (Tsinghua University) 1. Crystal structure of the human prostaglandin E receptor EP4 Yosuke Toyoda Department of Medical Chemistry and Cell Biology, Kyoto University Graduate School of Medicine; School of Medicine, Tsinghua University 2. A crystal structure of the lysophospholipid receptor LPA6and insights into lipid ligand entry and a hereditary hair disease Asuka Inoue Graduate School of Pharmaceutical Sciences, Tohoku University, PRIME, Japan Agency for Medical Research and Development (AMED) 3. Endothelin Receptor – Ligand binding and conformational changes Tomoko Doi Graduate School of Science, Department of Biophysics, Kyoto University, Japan 10:30 - 10:50 Coffee break 11:00 - 12:00 Plenary Lecture 2 Chair: Takao Shimizu (The University of Tokyo) BLT1 and BLT2, two GPCRs for lipid mediators Takehiko Yokomizo Department of Biochemistry, Graduate School of Medicine, Juntendo University, Japan 12:00 - 13:00 Break for lunch (by your own) 6 Programme 13:00 - 14:30 Session 4. Drug discovery based on GPCRs Chair: Kenji Kangawa (National Cerebral and Cardiovascular Center), Chair: Hiroyuki Kaiya (National Cerebral and Cardiovascular Center) 1. The Discovery of Histamine H4 Receptor Antagonists for the treatment of Inflammation Robin L. Thurmond Janssen Research & Development, LLC San Diego, CA 92121 2. Employing novel chemogenetic approaches to defining GPCR-biology Andrew B. Tobin Institute for Molecular and cell and systems biology, University of Glasgow, Glasgow, G12 8QQ, UK 3. Prediction of cancer-associated hotspot mutations that affect GPCR oligomerization Wataru Nemoto Department of Science and Technology, Tokyo Denki University, Saitama, Japan 14:30 - 15:00 Coffee break 15:00 - 16:30 Session 5. GPCR and Diseases Chair: Kazuwa Nakao (Kyoto University) Chair: Masaki Tanaka (Kyoto Prefectural University of Medicine) 1. Structure-based Discovery of Non-metabolite Synthetic Ligands for Metabolite Receptors - exploding Orthosteric versus Allosteric Locks Thue W.Schwartz Center for Basic metabolic Research, University of Copenhagen, Copenhagen Denmark 2. Autocrine Regulation of Metabolic Functions Through Metabolite GPCRs Stefan Offermanns Dept. of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany, Medical Faculty, J. W. Goethe University, Frankfurt, Germany 3. Functional analysis of dry syndrome by PACAP and its prevention and possible use for therapeutic application Seiji Shioda Peptide Drug Innovation, Global Research Center for Innovative Life Science, Hoshi University 16:30 - 16:40 Closing remark 7 Programme Poster presentations (16:30 - 17:30, Day 1, Jun/29/2018 (Fri)) 1. Allosteric transmission with rigidity propagation across GPCR networks Adnan Sljoka Kwansei Gakuin University, Japan 2. Illuminating G12-coupled GPCRs Asuka Inoue Graduate School of Pharmaceutical Sciences, Tohoku University, PRIME, Japan Agency for Medical Research and Development (AMED) 3. Identification of ghrelin and its receptor in Schlegel's Japanese gecko, Gekko japonicus Hiroyuki Kaiya Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Japan 4. Effect of MRS2578, a P2Y6 receptor inhibitor, on IgE-dependent activation of human basophils Manabu Nakano Graduate School of Health Sciences, Department of Bioscience and Laboratory Medicine, Hirosaki University, Japan, 2 Graduate School of Health Sciences, Research Center for Biomedical Sciences, Hirosaki University Japan 5. RNA editing of 5-HT2C in the nucleus accumbens participates in alcohol drinking behavior Masaki Tanaka Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan 6. The Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide increases food intake by modulating the expression of neuropeptides in the mouse hypothalamus Nguyen Thanh Trung Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan 7. Recent progress on screening for novel GPCR ligands using GPCR-G fusion proteins Shigeki Takeda Faculty of Science and Technology, Division of Molecular Science, Gunma University 8 Programme 8. Functional analysis