ALABAMA’S BIO-INDUSTRY OVERVIEW Alabama’s multifaceted biosciences industry generates $7.3 billion in economic activity BIOSCIENCES annually while supporting 780 companies and nearly 48,000 direct and indirect jobs GENERATED across the state, according to an analysis by researchers at the University of Alabama. $7.3 BILLION Alabama’s biosciences sector is a robust combination of research institutions, labs, medical devices, innovative startups, pharmaceutical manufacturers, and more. IN ECONOMIC ACTIVITY BIO-INDUSTRY INNOVATION SUPPORTING Bioscience-Related U.S. Patents Bioscience-Related U.S. Patents 2014-2017 by Segment 2014-2017 780 53 Agricultural Chemicals COMPANIES 2014 161 Biochemistry 134 Bioinformatics & Health IT 9 2015 142 Biological Sampling & Analysis 42 Drugs & Pharmaceuticals 335 2016 159 Genetics 19 2017 141 Medical & Surgical Devices 240 Microbiology & Enzymes 37 Novel Plant Variants 14 Source: Bio.org, Alabama: Investment, Innovation and Job Creation in a Growing U.S. Bioscience Industry 2018 www.bio.org/value-bioscience-innovation-growing-jobs-and- improving-quality-life-2018 Bioscience Academic R&D Expenditures 48,000 $ Millions FY 2016 DIRECT AND Health Sciences $373.3 INDIRECTJOBS Biological & Biomedical $152.1 ACROSS THE Sciences Agricultural STATE Sciences $72.0 Other Life $29.4 Sciences Bioengineering Source: BioAlabama / Biomedical $4.0 Engineering www.edpa.org / (205)943-4700 / ALABAMA’S BIO-INDUSTRY NATIONAL INSTITUTES OF HEALTH FUNDING $450,000 NIH Funding ($ thousands) Alabama’s Top NIH-funded Research Institutions $400,000 $350,000 University of Alabama at Birmingham $300,000 University of South Alabama $250,000 Auburn University $200,000 University of Alabama $150,000 Southern Research Institute $100,000 $294,964 $298,159 $280,132 $228,361 $350,735 $391,578 $253,111 HudsonAlpha Institute of Biotechnology $50,000 $254,389 Source: National Institutes of Health, NIH Awards by Location & $- Organization - U.S. FY2019 2012 2013 2014 2015 2016 2017 2018 2019 ASSETS SUPPORTING BIO-INDUSTRY AIMTech Access to partnerships between higher Innovation Depot is a 140,000 sq. ft. education and the research community incubation facility and program that creates a favorable environment for the BioAlabama is a nonprofit that focuses on the development of emerging biotech industry. AIMTech is an assists startups in a number of biotechnology, life sciences, information example of this partnership. It is a joint ways, including matching them technology, and service business. The project between the University of with mentors and helping them Center has 20,000 square feet of wet Alabama at Birmingham and identify sources of capital, from laboratory space and a shared equipment Southern Research to increase grants to early- and growth-stage lab with an autoclave, centrifuge, low commercialization potential of medical equity funding. temp freezer and micro-optics. devices. Southern Research (SR) is an independent, 501(c)(3) nonprofit, The 270,000-square-foot Institute is scientific research organization pursuing a world-class genomic research entrepreneurial and collaborative center that is continually working to Alabama initiatives to develop and maintain a improve human health and well- pipeline of intellectual property and being, while facilitating the Innovation innovative technologies that positively entrepreneurial growth of scientific Fund impact real-world problems. discoveries in collaboration with over Southern Research has Developed 30 diverse associate companies Provides support to the state’s universities 7 FDA Approved Cancer Drugs. located on site. and other research institutions to promote commercialization and create economic development opportunities. www.edpa.org / (205)943-4700 / ALABAMA’S BIO-INDUSTRY TALENT PRODUCER—GREAT UNIVERSITIES Alabama has eight research universities across the state that have a strong bioscience-related focus. University of Alabama at Birmingham Bill L. Harbert Institute for Innovation and Entrepreneurship actively seeks national and international companies that wish to develop and commercialize UAB's innovations. University of Alabama in Huntsville Office of Technology Commercialization acts as a liaison between university innovators and industry investors. 8 Auburn University Office of RESEARCH Innovation Advancement & Commercialization serves as the link UNIVERSITIES between the commercial marketplace IN ALABAMA and Auburn University faculty. University of South Alabama’s University of Alabama Office for Technology Office of Commercialization and Transfer is responsible for commercializing the Industry Collaboration assists innovations generated by UA faculty, staff and faculty in turning their inventions into students, through licenses to industry or via the marketable products. formation of spin-off enterprises. www.edpa.org / (205)943-4700 / ALABAMA’S BIO-INDUSTRY COMPANY HIGHLIGHTS Throughout Alabama are concentrations of large and small, new and well-established bioscience and related companies. A UAB spinout company located in Pharmavite is one of the nation’s largest Birmingham, Discovery BioMed specializes manufacturers of high quality vitamins, Cummings Research Park is home in custom human cell engineering and human minerals and other dietary supplements. In to the 2nd largest research park in cell-based drug discovery. The company 2013, after conducting an extensive site the U.S. supports the commercial and academic drug search in the U.S., Pharmavite, the maker of discovery community by integrating human Nature Made vitamins and supplements, cell research platforms at any and all points opened a $76 million manufacturing facility within the drug discovery critical path. in Opelika. With international headquarters in Evonik Industries is a leader in Birmingham, BioHorizons is one of the fastest bioresorbable polymer and injectable drug -growing global implant and biologics delivery technologies. In 2014, Evonik companies in the dental implant industry. Its opened its first U.S. Innovation Center in portfolio includes dental implants, instruments Birmingham. The Center is focused on and biologics products. medical devices and technology. BioHorizons is a medical technology company Evonik specializes in drug delivery University of South Alabama focused on dental implants, as well as hard and technologies and manufacturing for soft tissue regeneration products, for the pharmaceutical, biotechnology, and medical Technology Park, located in replacement of missing teeth. BioHorizons has device companies and employs 800 people in Mobile, serves to facilitate products in 90 markets around the globe. Alabama. interaction between the University and the high-tech and biomedical businesses. Baxter Incorporated makes hemodialysis Located in the HudsonAlpha, Huntsville dialyzers, and high-tech blood filtering iCubate is a privately-held molecular product used in kidney dialysis treatment. In diagnostic company. The integrated iCubate 2017, the facility, located in Opelika, System enables extraction, multiplexed completed a $270 million expansion project amplification and detection automatically in a that more than doubled the size of its closed and disposable cassette. iCubate production facility to increase production of provides a sample-in answer-out diagnostic dialyzers to serve patients with end-stage test with high multiplexing ARM-PCR renal disease. technology in a user friendly, flexible platform. Other iCubate products are available world- wide for non-clinical, research-use only in the areas of health, agriculture, and food safety. Auburn Research Park is 170 acre mixed-use campus GeneCapture in Huntsville was awarded a incorporating high technology $1 million, two-year Small Business companies, university research Serina Therapeutics in Huntsville developed Technology Transfer Research (STTR) facilities, business support a proprietary polymer technology designed to contract to develop a portable disease centers, and technology transfer optimize drug delivery to maximize detector. This is a “gene signature matching compliance, therapeutic outcomes, safety and platform” that screens for hundreds of capabilities quality of life for patients. pathogens in less than one hour. www.edpa.org / (205)943-4700 .