USOO6342350B1 (12) United States Patent (10) Patent No.: US 6,342,350 B1 Tanzi et al. (45) Date of Patent: Jan. 29, 2002 (54) ALPHA-2-MACROGLOBULIN DIAGNOSTIC with Chinese late onset Alzheimer's Disease,” Neuroscience TEST Letters 269:173–177 (1999). Dodel, R.C., et al., “C-2 Macroglobulin and the Risk of (75) Inventors: Rudolph E. Tanzi, Hull; Bradley T. Alzheimer's Disease,” Neurology 54:438-442 (2000). Hyman, Swampscott; George W. Dow, D.J., et al., “C-2 Macroglobulin Polymorphism and Rebeck, Somerville; Deborah L. Alzheimer Disease risk in the UK,” Nature Genetics Blacker, Newton, all of MA (US) 22:16–17 (May 1999). (73) Assignee: The General Hospital Corporation, Du, Y., et al., “c-Macroglobulin Attenuates B-Amyloid Boston, MA (US) Peptide 1-40 Fibril Formation and Associated Neurotoxicity of Cultured Fetal Rat Cortical Neurons,” J. of Neurochem. 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