Definite High Risk Moderate to Significant Risk Generic Name Brand Name/Manufacturer Labeled Uses Generic Name Brand Name/Manufacturer Labeled Uses Oncovin/Eli Lilly; Fluoroquinolones (see specific drug names) Vincasar PFS/Pfizer; Acute leukemia; malignant Vincristine sulfate Vincristine Sulfate Injection/ lymphomas and carcinomas Pneumonia and bronchitis; Tequin/Bristol-Myers Squibb; Abbott, Mayne sinus, respiratory tract, and Gatifloxacin Tequin Injection/Bristol-Myers urinary tract infections; sexually Squibb Cabazitaxel Jevtana/Sanofi-Aventis Advanced prostate cancer transmitted diseases Breast and prostate Docetaxel Taxotere/Sanofi-Aventis Gold Salts (see specific drug names) carcinomas; lung cancer Gold Sodium Onxol/IVAX; Breast, lung, ovarian Aurolate/Taylor Rheumatoid arthritis Paclitaxel Paclitaxel Injection/UDL, Bedford and esophageal Thiomalate Taxol/Bristol-Myers Squibb carcinomas Charcot-Marie-Tooth Association Ipilimumab Yervoy/ Bristol-Myers Squibb Melanoma Taxols (see specific drug names) Metastatic or locally Ixabepilone Ixempra/Bristol-Myers Squibb advanced breast cancer Moderate to Significant Risk Leflunomide Arava/Aventis Rheumatoid arthritis Ventricular arrhythmias (fibrilla- Amiodarone HCL Cordarone/Wyeth-Ayerst tion and tachycardia) Lenalidomide Revlimid/Celgene Myelodysplastic syndrome Arsenic Trioxide Trisenox/Cephalon Acute promyelocytic leukemia Infections, including skin, Levofloxacin Levaquin/Ortho-McNeil respiratory, and urinary tract CMT MEDICAL Auranofin Ridaura/Prometheus Rheumatoid arthritis infections; venereal diseases Aurothioglucose Solganal/Schering Rheumatoid arthritis Intestinal, vaginal and Metronidazole (risk with other bacterial infections; Flagyl/Pfizer ALERT extended use) septicemia; peritonitis; Multiple myeloma (bone Bortezomib Velcade/Millenium cancer) endocarditis Hodgkin’s lymphoma; systemic Misonidazole (risk with Cancer treatment; Brentuximab Vedotin Adcetris/Seattle Genetics Neurotoxic Medication List anaplastic large cell lymphoma extended use) radiotherapy Cancer of the head, neck or Skin and respiratory tract Cetuximab Erbitux/Lilly Moxifloxacin Avelox/Bayer colon infections Bacterial infections, including Nitrofurantoin Capsules/ Nitrofurantoin; Sandoz; skin, bone, blood, urinary, Urinary tract infections Ciprofloxacin Cipro; Cipro IV/Bayer respiratory, and gastrointestinal Macrodantin Macrobid/Proctor & Gamble; tract infections; pneumonia; Furadantin/Elan sinusitis; typhoid fever Nitrous Oxide (risk with The medications listed in this table are potentially toxic Cisplatin Injection/Abbot, inhalation abuse or General anesthesia American Pharmaceutical vitamin B12 deficiency) to CMT patients. Vincristine has been proven hazardous Bladder, ovarian, and testicular Cisplatin Partners, Baxter; Melanoma, advanced renal cell and should be avoided by all CMT patients, including carcinomas Nivolumab Opdivo/ Bristol-Myers Squibb Platinol-AQ/Bristol-Myers carcinoma those with no symptoms. Taxols also pose a high risk to Squibb Urinary tract infections; prosta- people with CMT. The remainder of the medications listed Colchicine Tablets/Abbot; Norfloxacin Noroxin/Merck Gout prevention; gouty arthritis; titis; gonorrhea Colchicine (risk with Colchicine Injection/Bedford; present varying degrees of potential risk for worsening CMT (unlabeled use: hepatic cirrho- extended use) Probenecid and Colchicine sis due to alcohol) Oxaliplatin Eloxatin/Sanofi-Synthelabo Colorectal carcinoma neuropathy. Tablets/IVAX, Truxton Urinary tract, skin, bone, and Bullous herpetiformis dermati- Ofloxacin Floxin/Ortho-McNeil Dapsone Dapsone Tablets/Jacobus heart infections Before taking any medication or changing medication, all tis; leprosy Melanoma, non-small-cell lung CMT patients should make sure the treating physician is Didanosine; Pembrolizumab Keytruda/Merck Videx/Bristol-Myers Squibb HIV infection cancer fully aware of their medical condition. Dideoxyinosine (ddI) Perhexiline (not used Pexsig/Sigma (Australia and Not FDA approved; in clinical Angina pectoris Dichloroacetate (DCA) Chronic lactic acidosis in US) New Zealand) (Note: This table is not a complete list of brand names, trials manufacturers, or labeled uses. There may be others, and Pomalidomide Pomalyst/Celgene Multiple myeloma Disulfiram Antabuse/Odyssey Alcoholism patients should be aware that many drugs have off-label Urinary tract infections; uses. Always check the ingredients before taking any Enoxacin Penetrex/Aventis gonorrhea Vitamin B6 deficiency; medication.) Pyridoxine (risk with Vitelle Nestrex/Fielding antidote to drug-induced Metastatic breast cancer (pa- megadoses) neuropathy Revised 04/2017 Eribulin Mesylate Halaven/Eisai tients who have received two prior chemotherapy regimens) Moderate to Significant Risk Uncertain or Minor Risk Negligible or Doubtful Risk Generic Name Brand Name/Manufacturer Labeled Uses Generic Name Brand Name/Manufacturer Labeled Uses Generic Name Brand Name/Manufacturer Labeled Uses Lower respiratory Apresoline/IVAX; Zyloprim/Prometheus; Gout; gouty arthritis; kidney Sparfloxacin Zagam/Bertek tract infections Hydra-zide/Par; Allopurinol Hydralazine Hypertension Aloprim/Nabi and urinary tract stones Apresazide/Novartis; Stavudine (d4T) Zerit/Bristol-Myers Squibb HIV infection Marpres/Marnel Amitriptyline Elavil/Zeneca Depression Testicular germ cell carcinoma; African sleeping sickness; river Ifosfamide Ifex/Bristol-Myers Squibb Cloramphenicol Sodium bone and soft tissue sarcomas Suramin Awaiting FDA approval blindness; experimental cancer Succinate/American Chloramphenicol Meningitis; typhoid fever treatment (prostate) Rheumatoid arthritis; Infliximab Remicade/Centocor Pharmaceutical Partners; Erythema (reddening of the Crohn’s disease Chloromycetin/Monarch skin); nosodum leprosum (a Nydrazid/Sandoz; rash associated with treatment Isoniazid (INH) Tuberculosis Chlorprothixene Taractan/Roche Psychosis Thalidomide Thalomid/Celgene Laniazid/Lannett of leprosy); many other off-la- Ulcers;gastroesophageal Tagamet/GlaxoSmithKline; bel uses (mainly autoimmune Gastric and duodenal Lansoprazole Prevacid/TAP Phramaceuticals reflux disease (GERD); Zolliger- Cimetadine Hydrocloride disease and chemotherapy) Cimetidine ulcers; gastroesophageal Ellison Syndrome Injection/American Trovafloxacin Pneumonia; abdominal, pelvic, reflux Trovan/Pfizer Regent, Hospira, Endo (Alatrofloxacin) and skin infections Lovastatin/Mylan, Par, Sandoz, Teva; Clioquinol is an ingredient in Zalcitabine; Lovastatin Elevated LDL cholesterol Hivid/Roche HIV infection Mevacor/Merck; Dideoxycytidine (ddC) many formulations (often Dermatitis; folliculitis; Altocor/Andrx Clioquinol with hydrocortisone) used eczema; athlete’s foot; Prevention and treatment of to treat bacterial and fungal jock itch; ringworm Uncertain or Minor Risk Mefloquine Lariam/Roche malaria infections of the skin Adrucil/Pfizer; Breast, colorectal, gastric and Ulcers; gastroesophageal 5-Fluorouracil; (5-FU) Fluorouracil injection/Baxter, Prilosec/Proctor and Gamble; Clofibrate Atromid/Wyeth-Ayerst Hyperlipidaemias pancreatic carcinomas Omeprazole reflux disease (GERD); Zolliger- Valeant, SoloPak, APP Zegerid/ Santarus Ellison Syndrome Prevention of rejection of Adriamycin Adriamycin/Bedford; Leukemia; lymphomas; Dilantin/Pfizer; Sandimmune; organ transplants; severe (Doxorubicin HCL) Adriamycin RDF/Pfizer carcinomas Cyclosporin A Phenytoin Phenytoin Sodium Injection/ Epilepsy; convulsions; seizures Neoral/Novartis cases of psoriasis and Vectarion/Not manufactured Baxter, Hospira, Sanofi rheumatoid arthritis Almitrine Acute respiratory failure bin US Podophyllin resin (high Removal of benign growths Vasotec/Biovail; Hypertension; congestive Elevated LDL risk with excessive time and warts, esp. external genital Enalapril Enalaprilat Injection/Abbott, Atorvastatin Lipitor/Pfizer heart failure cholesterol exposure or unintended Podocon-25/Paddock and perianal exophytic warts Baxter, Bedford, Faulding route--oral; deep caused by human papilloma- Aralen Phosphate/Sanofi- injection) virus (HPV) Gluthethimide Not currently in use Insomnia Synthelabo; Chloroquine Amebiasis; malaria Aralen Hydrochloride/Sanofi- Pravachol; Pravigard/Bristol- Pravastatin Elevated LDL cholesterol Lithium Carbonate/Rugby, Synthelabo Myers Squibb Roxane; Bipolar disorder (manic/ Cytarabine (Ara-C; Cytarabine Injection/Mayne, Lithium Leukemias; Rosuvastatin Crestor/AstraZeneca Elevated LDL cholesterol Lithobid/Solvay; depressive disorder) Cytosine arabinoside); Bedford; Lymphomatous Eskalith/GlaxoSmithKline Cytarabine liposomal Cytosar-U/Pfizer meningitis Depression; panic attacks; (risk with high doses) DepoCyt/Enzon Sertraline Zoloft/Pfizer obsessivecompulsive disor- Phenelzine Nardil/Pfizer Depression Ethambutol Tablets/Versa; der; PTSD; social disorder Ethambutol Tuberculosis Propafenone HCL/Watson; Atrial fibrillation; Myambutol/Elan Propafenone Simvastatin Zocor/Merck Elevated LDL cholesterol Rythmol/Abbott ventricular arrhythmias Etoposide Capsules/Mylan; Acne; seborrheic dermatitis; VePescid/Bristol-Myers Squibb Statins (see specific Statins are generally prescribed to control cholesterol and Sulfacetamide Sulfathiazole eye and vaginal infections Etoposide for Injection/ drug names) triglyceride levels and to prevent coronary events. Abbot, Bedford, Gensia Sicor, Small cell lung carcinoma; Etoposide (VP-16) SuperGen; refractory testicular neoplasm Prevention of liver, kidney, Sulfabenzamide Numerous brand names Vaginitis Toposar/Pfizer; Tacrolimus (FK506) Prograf/Fujisawa and other organ transplant Sulfadiazine Tablets/Eon, VePescid,