This document contains information regarding the safe handling of laboratory chemicals and was prepared to comply with OSHA standard CFR 1910.1450. It was authored by Donald Albert and Joseph Bruno, and was adapted from a similar plan in effect at Yale University; the authors acknowledge invaluable assistance rendered by Thomas C. Oimet, Yale University. Edited 9 September 2016 C. Keeler Reviewed 21 September 2016 W. Nelligan 1 Contents LIST OF EMERGENCY CALL NUMBERS ................................................................................ 6 1.0 CHEMICAL HYGIENE PLAN .......................................................................................... 7 1.1 INTRODUCTION ............................................................................................................ 7 1.2 CHEMICAL HYGIENE RESPONSIBILITIES .............................................................. 8 CHEMICAL HYGIENE HIERARCHY....................................................................................... 10 1.3 DEFINITIONS ............................................................................................................... 11 1.3.1 Laboratory Definition ............................................................................................. 11 1.3.2 Hazardous Chemical Definition .............................................................................. 11 1.4 HAZARD IDENTIFICATION ...................................................................................... 13 1.5 TRAINING & INFORMATION ................................................................................... 13 1.5.1 Chemical Safety Training ....................................................................................... 13 1.5.2 Chemical Safety Information Sources .................................................................... 14 1.5.2.1 Safety Reference Literature ................................................................................. 14 1.5.2.2 Container Labeling .............................................................................................. 14 1.5.2.3 Safety data sheets (SDS) ..................................................................................... 15 1.5.2.4 Laboratory Signs ................................................................................................. 18 1.5.2.5 Hazard Communication Standard Pictograms .................................................... 20 1.6 CHEMICAL EXPOSURE ASSESSMENT ................................................................... 22 1.7 MEDICAL CONSULTATION & EXAMINATION .................................................... 22 PROCEDURE: ON-THE-JOB INJURIES ................................................................................... 24 1.8 CHEMICAL FUME HOOD EVALUATION ............................................................... 25 1.9 RESPIRATORY PROTECTION ................................................................................... 25 1.9.1 Respiratory Protection Program .............................................................................. 26 1.9.2 Inspection Checklist for Purifying Respirators ....................................................... 28 1.10 RECORDKEEPING ................................................................................................... 29 1.11 PROTOCOL SAFETY REVIEW .............................................................................. 29 2.0 STANDARD OPERATING PROCEDURES FOR WORKING WITH CHEMICALS .. 30 2.1 GOOD WORK PRACTICES/PROCEDURES FOR HANDLING LABORATORY CHEMICALS ........................................................................................................................... 30 2.1.1 General Guidelines.................................................................................................. 30 2.1.2 Personal Hygiene .................................................................................................... 31 2.1.3 Housekeeping .......................................................................................................... 31 2.2 WHEN NOT TO PROCEED WITHOUT REVIEWING SAFETY PROCEDURES ... 31 2 2.3 PROTECTIVE CLOTHING AND LABORATORY SAFETY EQUIPMENT ............ 32 2.3.1 General Consideration - Personal Protective Clothing/Equipment ........................ 32 2.3.2 Protection of Skin and Body .................................................................................. 33 2.3.2.1 Normal clothing worn in the laboratory .............................................................. 33 2.3.2.2 Protective clothing............................................................................................... 33 GLOVE TYPE SELECTION GUIDE .......................................................................................... 34 2.3.3 Protection of the Eyes ............................................................................................ 35 2.3.4 Protection of the Respiratory System .................................................................... 35 2.3.5 Laboratory Safety Equipment ................................................................................ 36 2.3.5.1 Chemical Fume Hoods ........................................................................................ 36 GUIDELINES FOR CHEMICAL FUME HOOD USE ............................................................... 38 2.3.5.2 Eyewashes and safety showers ............................................................................ 39 2.3.5.3 Fire Safety Equipment ......................................................................................... 39 2.4 CHEMICAL PROCUREMENT, DISTRIBUTION, AND STORAGE ........................ 39 2.4.1 Procurement ............................................................................................................ 39 2.4.2 Distribution ............................................................................................................. 40 2.4.3 Chemical Storage in the Laboratory ....................................................................... 40 2.4.3.1 Chemical Storage - Chemical Stability ............................................................... 41 2.4.3.2 Chemical Storage - Incompatible Chemicals ...................................................... 41 2.4.3.3 Chemical Storage in Cold Rooms and Refrigerators .......................................... 45 2.5 CHEMICAL SPILLS & ACCIDENTS.......................................................................... 45 2.5.1 General Information ................................................................................................ 45 2.5.2 Cleaning Up Chemical Spills .................................................................................. 45 2.5.3 Minor Chemical Spill .............................................................................................. 46 2.5.4 Major Chemical Spill .............................................................................................. 46 2.5.5 Mercury Spills ......................................................................................................... 47 2.5.6 Alkali Metal Spills .................................................................................................. 47 2.5.7 White Phosphorus ................................................................................................... 47 2.6 PERSONAL CONTAMINATION AND INJURY ....................................................... 47 2.6.1 General Information ................................................................................................ 47 2.6.2 Chemicals Spills on the Body ................................................................................. 48 2.6.2.1 Hydrofluoric Acid Skin Exposure ....................................................................... 48 2.6.3 Chemical Splash in the Eye ................................................................................... 49 2.6.4 Ingestion of Hazardous Chemicals ........................................................................ 49 3 2.6.5 Inhalation of Smoke, Vapors and Fumes ............................................................... 49 2.6.6 Burning Chemicals on Clothing.............................................................................. 50 2.6.7 Actions to be Avoided During Emergencies .......................................................... 50 2.7 FIRE AND FIRE RELATED EMERGENCIES ............................................................ 51 2.8 CHEMICAL WASTE DISPOSAL PROGRAM ........................................................... 52 2.8.1 Silica Gel Waste ...................................................................................................... 52 2.9 LABORATORY SHARPS DISPOSAL ........................................................................ 52 Chart #1 ..................................................................................................................................... 54 Chart #2 ..................................................................................................................................... 55 3.0 HEALTH AND SAFETY INFORMATION FOR WORK WITH CHEMICALS OF SPECIFIC HAZARD CLASS ...................................................................................................... 56 3.1 FLAMMABLE LIQUIDS .............................................................................................. 56 3.1.1 General Information ...............................................................................................