Common Name: ISOPROPYL ACETATE CAS Number: 108-21-4 RTK Substance number: 1074 DOT Number: UN 1220 Date: April 1997 Revision: April 2004 --------------------------------------------------------------------------- --------------------------------------------------------------------------- HAZARD SUMMARY * Isopropyl Acetate can affect you when breathed in. * If you think you are experiencing any work-related health * Contact can irritate and burn the eyes. problems, see a doctor trained to recognize occupational * Contact can cause severe skin burns. Repeated exposure diseases. Take this Fact Sheet with you. can cause dryness and cracking of the skin. * ODOR THRESHOLD = 4.1 ppm. * Breathing Isopropyl Acetate can irritate the nose, throat * The range of accepted odor threshold values is quite and lungs causing coughing, wheezing and/or shortness of broad. Caution should be used in relying on odor alone as breath. a warning of potentially hazardous exposures. * High exposure can cause headache, drowsiness, poor muscle coordination, unconsciousness and coma. WORKPLACE EXPOSURE LIMITS * Isopropyl Acetate may affect the liver. OSHA: The legal airborne permissible exposure limit * Isopropyl Acetate is a FLAMMABLE LIQUID and a (PEL) is 250 ppm averaged over an 8-hour DANGEROUS FIRE HAZARD. workshift. IDENTIFICATION NIOSH: No exposure limit has been established. Isopropyl Acetate is a colorless liquid with a fruity odor. It is used as a solvent for cellulose, plastics, oils and fats, and in ACGIH: The recommended airborne exposure limit is printing inks and perfume. 100 ppm averaged over an 8-hour workshift and 200 ppm as a STEL (short term exposure limit). REASON FOR CITATION * Isopropyl Acetate is on the Hazardous Substance List WAYS OF REDUCING EXPOSURE because it is regulated by OSHA and cited by ACGIH, * Where possible, enclose operations and use local exhaust DOT, NIOSH and NFPA. ventilation at the site of chemical release. If local exhaust * This chemical is on the Special Health Hazard Substance ventilation or enclosure is not used, respirators should be List because it is FLAMMABLE. worn. * Definitions are provided on page 5. * Wear protective work clothing. * Wash thoroughly immediately after exposure to Isopropyl HOW TO DETERMINE IF YOU ARE BEING Acetate and at the end of the workshift. * Post hazard and warning information in the work area. In EXPOSED addition, as part of an ongoing education and training The New Jersey Right to Know Act requires most employers effort, communicate all information on the health and to label chemicals in the workplace and requires public safety hazards of Isopropyl Acetate to potentially employers to provide their employees with information and exposed workers. training concerning chemical hazards and controls. The federal OSHA Hazard Communication Standard, 1910.1200, requires private employers to provide similar training and information to their employees. * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.1020. ISOPROPYL ACETATE page 2 of 6 This Fact Sheet is a summary source of information of all MEDICAL potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance Medical Testing and other factors will affect your susceptibility to any of the If symptoms develop or overexposure is suspected, the potential effects described below. following are recommended: --------------------------------------------------------------------------- * Lung function tests. HEALTH HAZARD INFORMATION * Liver function tests. * Evaluate for brain effects such as changes in memory, Acute Health Effects concentration, sleeping patterns and mood (especially The following acute (short-term) health effects may occur irritability and social withdrawal), as well as headaches and immediately or shortly after exposure to Isopropyl Acetate: fatigue. Consider evaluations of the cerebellar, autonomic and peripheral nervous systems. Positive and borderline * Contact can irritate and burn the eyes. individuals should be referred for neuropsychological * Contact can cause severe skin burns. testing. * Breathing Isopropyl Acetate can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of Any evaluation should include a careful history of past and breath. present symptoms with an exam. Medical tests that look for * High exposure can cause headache, drowsiness, poor damage already done are not a substitute for controlling muscle coordination, unconsciousness and coma. exposure. Chronic Health Effects Request copies of your medical testing. You have a legal right The following chronic (long-term) health effects can occur at to this information under OSHA 1910.1020. some time after exposure to Isopropyl Acetate and can last for months or years: Mixed Exposures * Because smoking can cause heart disease, as well as lung Cancer Hazard cancer, emphysema, and other respiratory problems, it may * According to the information presently available to the New worsen respiratory conditions caused by chemical exposure. Jersey Department of Health and Senior Services, Even if you have smoked for a long time, stopping now will Isopropyl Acetate has not been tested for its ability to reduce your risk of developing health problems. cause cancer in animals. * Because more than light alcohol consumption can cause Reproductive Hazard liver damage, drinking alcohol may increase the liver damage caused by Isopropyl Acetate. * According to the information presently available to the New Jersey Department of Health and Senior Services, WORKPLACE CONTROLS AND PRACTICES Isopropyl Acetate has not been tested for its ability to affect reproduction. Unless a less toxic chemical can be substituted for a hazardous Other Long-Term Effects substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to * Repeated exposure can cause dryness and cracking of the enclose operations and/or provide local exhaust ventilation at skin. the site of chemical release. Isolating operations can also * Isopropyl Acetate can irritate the lungs. Repeated reduce exposure. Using respirators or protective equipment is exposure may cause bronchitis to develop with cough, less effective than the controls mentioned above, but is phlegm, and/or shortness of breath. sometimes necessary. * Isopropyl Acetate may affect the liver. * This chemical has not been adequately evaluated to In evaluating the controls present in your workplace, consider: determine whether brain or other nerve damage could occur (1) how hazardous the substance is, (2) how much of the with repeated exposure. However, many solvents and other substance is released into the workplace and (3) whether petroleum-based chemicals have been shown to cause such harmful skin or eye contact could occur. Special controls damage. Effects may include reduced memory and should be in place for highly toxic chemicals or when concentration, personality changes (withdrawal, irritability), significant skin, eye, or breathing exposures are possible. fatigue, sleep disturbances, reduced coordination, and/or effects on nerves supplying internal organs (autonomic In addition, the following controls are recommended: nerves) and/or nerves to the arms and legs (weakness, "pins and needles"). * Where possible, automatically pump liquid Isopropyl Acetate from drums or other storage containers to process containers. ISOPROPYL ACETATE page 3 of 6 * Before entering a confined space where Isopropyl Acetate Respiratory Protection may be present, check to make sure that an explosive IMPROPER USE OF RESPIRATORS IS DANGEROUS. concentration does not exist. Such equipment should only be used if the employer has a written program that takes into account workplace conditions, Good WORK PRACTICES can help to reduce hazardous requirements for worker training, respirator fit testing and exposures. The following work practices are recommended: medical exams, as described in OSHA 1910.134. * Workers whose clothing has been contaminated by * Where the potential exists for exposure over 100 ppm, use Isopropyl Acetate should change into clean clothing a NIOSH approved supplied-air respirator with a full promptly. facepiece operated in a pressure-demand or other positive- * Contaminated work clothes should be laundered by pressure mode. For increased protection use in combination individuals who have been informed of the hazards of with an auxiliary self-contained breathing apparatus exposure to Isopropyl Acetate. operated in a pressure-demand or other positive-pressure * Eye wash fountains should be provided in the immediate mode. work area for emergency use. * Exposure to 1,800 ppm is immediately dangerous to life * If there is the possibility of skin exposure, emergency and health. If the possibility of exposure above 1,800 ppm shower facilities should be provided. exists, use a NIOSH approved self-contained breathing * On skin contact with Isopropyl Acetate, immediately wash apparatus with a full facepiece operated in a pressure- or shower to remove the chemical. At the end of the demand or other positive-pressure mode equipped with an workshift, wash any areas of the body that may have emergency escape air cylinder. contacted Isopropyl Acetate, whether or not known skin contact has occurred. HANDLING AND STORAGE * Do not eat, smoke,
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