JNC The Offi cial Journal of the International Society for Neurochemistry Journal of Neurochemistry VOLUME 134 | SUPPLEMENT 1 | AUGUST 2015 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian-Pacifi c Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society 23–27 August 2015 Cairns, Australia wileyonlinelibrary.com/journal/jnc JNC The Offi cial Journal of the International Society for Neurochemistry Front cover: CD11c immunopositive microglia were observed in the subiculum in a brain section from the APPSwDI/ mNos2-/- mouse model of Alzheimer’s disease. These cells demonstrate genes associated with immunosuppression and express arginase 1. Sections were prepared and immunostained by Angela Everhart and the photograph was taken by Carol Colton using a Nikon Digital Sight DS Qi1mc camera and a Nikon Eclipse TE200 microscope. Contents Pages Sunday, August 23 15:30 – 17:30 S01 History of Neurochemistry 8 18:15 – 19:15 PL01 Plenary lecture 1 1 Monday August 24 08:30 – 09:30 PL02 Plenary lecture 2 2 09:30 – 10:00 YL01 Young Investigator Lectureship 6 10:30 – 12:30 S02 GSK3 Signaling in Alzheimer’s Disease Pathogenesis and Drug Development 10 10:30 – 12:30 S03 A Glial Spin on CNS Regeneration: Mechanisms that Regulate Oligodendrocyte 12 Remyelination 10:30 – 12:30 S04 Autophagy and Mitophagy in Neurodegeneration: From Basic Mechanisms to 14 prospects for Therapy 10:30 – 12:30 S05 Harnessing Human Genetics to defi ne the Biochemical Pathways involved in Brain 16 Development 14:30 – 16:30 S06 Biological and Therapeutic Roles of Glycine Receptors 18 14:30 – 16:30 S07 Microglia–Vasculature Interactions as Determinants of Neurologic Diseases and 20 Stroke 14:30 – 16:30 S08 Neuroimaging of Dense Core Vesicle Traffi cking and Release 22 14:30 – 16:30 S09 Control of Cognition and Emotion at the Neuron–Matrix Interface 23 17:00 – 19:00 S39 Chronic Pain: Lessons From Animal Models To Human Studies 81 17:00 – 19:00 W02 Development of Animal Models, a permanent Challenge in Neurosciences 84 17:00 – 19:00 S10 Novel Mechanisms in Synaptic Plasticity 25 17:00 – 19:00 S11 The Impact of Nutrition and Gut Microbiota on Multiple Sclerosis and other 27 Neurodegenerative Diseases: a story yet to be written Tuesday August 25 08:30 – 09:30 PL03 Plenary lecture 3 3 09:30 – 10:00 YL02 Young Investigator Lectureship 7 10:30 – 12:30 S12 Activity–Driven Epigenetic Mechanisms in the Brain 29 10:30 – 12:30 S13 New advances in Tau Regulation and Function 31 10:30 – 12:30 S14 Emerging principles of astroglia–neuron networking 33 10:30 – 12:30 S15 Neurochemistry of Decision Making & Reward–Seeking 35 14:30 – 16:30 S16 Synaptic defects in Intellectual Disability Syndromes and Autism 37 14:30 – 16:30 W06 Brain Environment in Motor Neuron Degeneration and Injury 91 14:30 – 16:30 S17 CNS Myelination: an Update on Novel Regulatory Mechanisms 39 14:30 – 16:30 S18 Extracellular Vesicles: Their Role in Neuronal Signaling in Health and Disease 41 17:00 – 19:00 S24 Neuroglia in Ageing and Neurodegeneration 52 17:00 – 19:00 W03 Challenge for Central Nervous System Regeneration: A Synergistic Approach 86 Combining Neurobiology and Biomaterial Engineering 17:00 – 19:00 W04 Microtubule–based therapy for Alzheimer’s disease and other tauopathies 88 17:00 – 19:00 S19 Molecular Determinants of Homeostatic Plasticity in the Brain 43 Contents Pages Wednesday 26 August, 2015 08:30 – 09:30 PL04 Plenary lecture 4 4 10:30 – 12:30 S20 Microglia Plasticity – Molecular Characteristics of Different Phenotypes 44 10:30 – 12:30 S21 What do HCN Channels Teach us about Health and Disease? 46 10:30 – 12:30 S22 Synaptic Cell Adhesion in Development and Plasticity 48 10:30 – 12:30 S23 Lipids in Normal and Pathological Neuronal Function 50 14:30 – 16:30 W01 Neuroepigenetics: from Neural Development to Adult Neurogenesis 82 14:30 – 16:30 S25 Cellular and Molecular Approaches to Study Pathomechanisms of Familial PD 53 14:30 – 16:30 S26 What is Glycogen doing in the Brain? – Biochemistry, Physiology, Pathology 55 14:30 – 16:30 S27 Temporal Evolution of Microglial Function and Phenotype in Ischemic Injury 57 17:00 – 19:00 W05 “How to publish a good paper? (Quality, Reproducibility and Impact)” 90 17:00 – 19:00 S28 Neuroinformatics Tools and Neurochemical Atlases for Global Neuroscience 59 Collaboration 17:00 – 19:00 S29 Optogenetics and Optopharmacology to Illuminate the Brain 61 17:00 – 19:00 S38 New roles of Neural Glycosaminogycans (GAGs) in Development, Plasticity, 79 Regeneration and Disease Thursday August 27 08:30 – 10:00 YIC01 Circuitry Plasticity and Development 93 08:30 – 10:00 YIC02 Mechanisms of glial function, including infl ammation 95 08:30 – 10:00 YIC03 Behavior, Addiction, Psychobiology 97 08:30 – 10:00 YIC04 Disease, Neurodegeneration, Therapy 99 10:30 – 12:30 S30 Nucleotide Repeat Sequences in Neurodegeneration 63 10:30 – 12:30 S31 Non–coding RNAs: Important Regulators in the Nervous System 65 10:30 – 12:30 S32 Central Role of Glial Cells in the Pathogenesis of Schizophrenia 67 10:30 – 12:30 S33 The Endocannabinoid System and Brain Function: Problems and Possibilities 69 14:30 – 16:30 S34 From Mechanisms to Novel Therapeutic Targets in Combating Epileptogenesis and 71 Epilepsy 14:30 – 16:30 S35 Molecular Mechanisms of Neurotransmission: Coupling Exocytosis and 73 Compensatory Endocytosis 14:30 – 16:30 S36 Astrocyte Gliotransmission, Metabolism and Behavior 75 14:30 – 16:30 S37 Long–distance Signaling in Control of the Transcriptomic and Proteomic Responses 77 to Neuronal Injury 17:00 – 18:00 PL05 Plenary lecture 5 / Lawrie Austin Lecture 5 Contents in Abstract Order First abstract Pages Plenary Lectures PL01 Plenary Lecture 1 - Professor Yoshinori Ohsumi PL01 1 PL02 Plenary Lecture 2 - Professor Franz-Ulrich Hartl PL02 2 PL03 Plenary Lecture 3 - Professor Ellen Closs PL03 3 PL04 Plenary Lecture 4 - Professor Leslie Vosshall PL04 4 PL05 Plenary Lecture 5 / Lawrie Austin Lecture - Professor Ashley Bush PL05 5 Young ISN Lecturers YSL01 Young Scientist Lecture 1 - Michael Fox YSL01 6 YSL02 Young Scientist Lecture 2 - Jess Nithianantharajah YSL02 7 Symposia S01 History of Neurochemistry S01-01 8 S02 GSK3 Signaling in Alzheimer’s Disease Pathogenesis and Drug Development S02-01 10 S03 A Glial Spin on CNS Regeneration: Mechanisms that Regulate S03-01 12 Oligodendrocyte Remyelination S04 Autophagy and Mitophagy in Neurodegeneration: From Basic Mechanisms to S04-01 14 Prospects for Therapy S05 Harnessing Human Genetics to Defi ne the Biochemical Pathways involved in S05-01 16 Brain Development S06 Biological and Therapeutic Roles of Glycine Receptors S06-01 18 S07 Microglia-Vasculature Interactions as Determinants of Neurologic Diseases S07-01 20 and Stroke S08 Neuroimaging of Dense Core Vesicle Traffi cking and Release S08-01 22 S09 Control of Cognition and Emotion at the Neuron-Matrix Interface S09-01 23 S10 Novel Mechanisms in Synaptic Plasticity S10-01 25 S11 The Impact of Nutrition and Gut Microbiota on Multiple Sclerosis and other S11-01 27 Neurodegenerative Diseases: a Story yet to be Written S12 Activity-Driven Epigenetic Mechanisms in the Brain S12-01 29 S13 New Advances in Tau Regulation and Function S13-01 31 S14 Emerging Principles of Astroglia-Neuron Networking S14-01 33 S15 Neurochemistry of Decision Making & Reward-Seeking S15-01 35 S16 Synaptic Defects in Intellectual Disability Syndromes and Autism S16-01 37 S17 CNS Myelination: an Update on Novel Regulatory Mechanisms S17-01 39 S18 Extracellular Vesicles: Their Role in Neuronal Signalling in Health and S18-01 41 Disease S19 Molecular Determinants of Homeostatic Plasticity in the Brain S19-01 43 S20 Microglia Plasticity - Molecular Characteristics of Different Phenotypes S20-01 44 S21 What do HCN Channels Teach us about Health and Disease? S21-01 46 S22 Synaptic Cell Adhesion in Development and Plasticity S22-01 48 S23 Lipids in Normal and Pathological Neuronal Function S23-01 50 S24 Neuroglia in Ageing and Neurodegeneration S24-01 52 Contents in Abstract Order First abstract Pages S25 Cellular and Molecular Approaches to Study Pathomechanisms of S25-01 53 Familial PD S26 What is Glycogen doing in the Brain? - Biochemistry, Physiology, Pathology S26-01 55 S27 Temporal Evolution of Microglial Function and Phenotype in Ischemic Injury S27-01 57 S28 Neuroinformatics Tools and Neurochemical Atlases for Global Neuroscience S28-01 59 Collaboration S29 Optogenetics and Optopharmacology to Illuminate the Brain S29-01 61 S30 Nucleotide Repeat Sequences in Neurodegeneration S30-01 63 S31 Non-coding RNAs: Important Regulators in the Nervous System S31-01 65 S32 Central Role of Glial Cells in the Pathogenesis of Schizophrenia S32-01 67 S33 The Endocannabinoid System and Brain Function: Problems and Possibilities S33-01 69 S34 From Mechanisms to Novel Therapeutic Targets in Combatting S34-01 71 Epileptogenesis and Epilepsy S35 Molecular Mechanisms of Neurotransmission: Coupling Exocytosis and S35-01 73 Compensatory Endocytosis S36 Astrocyte Gliotransmission, Metabolism and Behavior S36-01 75 S37 Long-distance Signaling in Control of the Transcriptomic and Proteomic S37-01 77 Responses to Neuronal Injury S38 New Roles of Neural Glycosaminogycans (GAGs) in Deveplopment, S38-01 79 Plasticity, Regeneration and Disease S39 Chronic Pain: Lessons from Animal Models to Human Studies S39-01 81 Workshops W01 Neuroepigenetics: from Neural Development to Adult Neurogenesis W01-01 82 W02 Development of Animal Models, a permanent Challenge in Neurosciences