177 (10) J Immunol 2006; 177:6571-7471; ; http://www.jimmunol.org/content/177/10 This information is current as of September 29, 2021. Downloaded from Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists http://www.jimmunol.org/ • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription by guest on September 29, 2021 Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. VOL. 177 Խ NO. 10 Խ November 15, 2006 Խ Pages 6571–7480 IMMUNOLOGY OF TABLE OF CONTENTS L 6571 In This Issue A Brief Reviews 6573 Nucleic Acid-Sensing TLRs as Modifiers of Autoimmunity N Jonathan A. Deane and Silvia Bolland Cutting Edge R 6579 Cutting Edge: CD4 Is the Receptor for the Tick Saliva Immunosuppressor, Salp15 Downloaded from Renu Garg, Ignacio J. Juncadella, Nandhini Ramamoorthi, Ashish, Shobana K. Ananthanarayanan, Venetta Thomas, Mercedes Rinco´n, Joanna K. Krueger, Erol Fikrig, Christopher M. Yengo, and Juan Anguita 6584 Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response OU Modifiers and PolyT Oligodeoxynucleotides J Keith K. B. Gorden, Xiaohong X. Qiu, Christine C. A. Binsfeld, John P. Vasilakos, and Sefik S. Alkan http://www.jimmunol.org/ THE 6588 Cutting Edge: Resistance to HIV-1 Infection among African Female Sex Workers Is Associated with Inhibitory KIR in the Absence of Their HLA Ligands Wim Jennes, Sonja Verheyden, Christian Demanet, Christiane A. Adje´-Toure´, Bea Vuylsteke,John N. Nkengasong, and Luc Kestens 6593 Cutting Edge: Inherent and Acquired Resistance to Radiation-Induced Apoptosis in B Cells: A Pivotal Role for STAT3 Dennis C. Otero, Valeria Poli, Michael David, and Robert C. Rickert by guest on September 29, 2021 6598 Cutting Edge: The Phosphoinositide 3-Kinase p110␦ Is Critical for the Function of ϩ ϩ ϩ CD4 CD25 Foxp3 Regulatory T Cells Daniel T. Patton, Oliver A. Garden, Wayne P. Pearce, Louise E. Clough, Clare R. Monk, Eva Leung, Wendy C. Rowan, Sara Sancho, Lucy S. K. Walker, Bart Vanhaesebroeck, and Klaus Okkenhaug Cellular Immunology and Immune Regulation 6603 Cyclophosphamide-Induced Type-1 Diabetes in the NOD Mouse Is Associated with a Reduction of ϩ ϩ ϩ CD4 CD25 Foxp3 Regulatory T Cells Sven Brode, Tim Raine, Paola Zaccone, and Anne Cooke On the cover: The purinergic P2X7 receptor localizes to the cell membrane of adjacent HEK 293 cells stably expressing the rat P2X7 coupled to GFP. The intensity of GFP-P2X7 fluorescence is shown on a rainbow scale going from blue (low level) to yellow and red (high level). 2006. Lemaire, I., S. Falzoni, N. Leduc, B. Zhang, P. Pellegatti, E. Adinolfi, P. Chiozzi, and F. Di Virgilio. Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells. J. Immunol. 177: 7257–7265. The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 9650 Rockville Pike, Bethesda,MD 20814-3994. Subscription term: New subscriptions and renewals begin January1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and details).A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/membership). Periodicals postage paid at Bethesda,MD 20814-3998, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes to The Journal of Immunology, Subscription Department, Room L-2407A, 9650 Rockville Pike, Bethesda,MD 20814-3998. Copyright© 2006 by The American Association of Immunologists, Inc. 6613 Coreceptor Signal Strength Regulates Positive Selection but Does Not Determine CD4/CD8 Lineage Choice in a Physiologic In Vivo Model Batu Erman, Amala S. Alag, Oyvind Dahle, Franc¸ois van Laethem, Sophia D. Sarafova, Terry I. Guinter, Susan O. Sharrow, Alexander Grinberg, Paul E. Love, and Alfred Singer 6626 Prime-Boost with Alternating DNA Vaccines Designed to Engage Different Antigen Presentation ϩ Pathways Generates High Frequencies of Peptide-Specific CD8 T Cells Joanna N. Radcliffe, Joanne S. Roddick, Peter S. Friedmann, Freda K. Stevenson, and Stephen M. Thirdborough 6634 Antibody Responses to Mycobacterial and Self Heat Shock Protein 65 in Autoimmune Arthritis: Epitope Specificity and Implication in Pathogenesis Hong Ro Kim, Eugene Y. Kim, Jan Cerny, and Kamal D. Moudgil 6642 Functional Dichotomy in CD40 Reciprocally Regulates Effector T Cell Functions Gopal Murugaiyan, Reena Agrawal, Gyan C. Mishra, Debashis Mitra, and Bhaskar Saha 6650 GATA-3 Regulates the Development and Function of Invariant NKT Cells Peter J. Kim, Sung-Yun Pai, Manfred Brigl, Gurdyal S. Besra, Jenny Gumperz, and I-Cheng Ho ϩ ϩ 6660 Immature CD4 CD8 Thymocytes and Mature T Cells Regulate Nur77 Distinctly in Response to Downloaded from TCR Stimulation Nicole R. Cunningham, Stephen C. Artim, Christen M. Fornadel, MacLean C. Sellars, Samuel G. Edmonson, Grant Scott, Frank Albino, Akriti Mathur, and Jennifer A. Punt 6667 Specific and Redundant Roles for NFAT Transcription Factors in the Expression of Mast Cell-Derived Cytokines http://www.jimmunol.org/ Matthias Klein, Stefan Klein-Hessling, Alois Palmetshofer, Edgar Serfling, Christine Tertilt, Tobias Bopp, Valeska Heib, Marc Becker, Christian Taube, Hansjo¨rg Schild, Edgar Schmitt, and Michael Stassen 6675 Partial versus Full Allogeneic Hemopoietic Chimerization Is a Preferential Means to Inhibit Type 1 Diabetes as the Latter Induces Generalized Immunosuppression David V. Serreze, Melissa A. Osborne, Yi-Guang Chen, Harold D. Chapman, Todd Pearson, Michael A. Brehm, and Dale L. Greiner ϩ 6685 Death of CD4 T Cells from Lymph Nodes during Primary SIVmac251 Infection Predicts the Rate of by guest on September 29, 2021 AIDS Progression Laurence Viollet, Vale´rie Monceaux, Fre´de´ric Petit, Raphae¨l Ho Tsong Fang, Marie-Christine Cumont, Bruno Hurtrel, and Je´roˆme Estaquier 6695 Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation Rodrigo Pacheco, Harold Oliva, Jose´M. Martinez-Navı´o, Nu´ria Climent, Francisco Ciruela, Jose´M. Gatell, Teresa Gallart, Josefa Mallol, Carmen Lluis, and Rafael Franco 6705 Quantification of Repertoire Diversity of Influenza-Specific Epitopes with Predominant Public or Private TCR Usage Katherine Kedzierska, E. Bridie Day, Jing Pi, Stephen B. Heard, Peter C. Doherty, Stephen J. Turner, and Stanley Perlman 6713 CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to ϩ ϩ Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23 CD5 B Cells Hu Chunsong, He Yuling, Wang Li, Xiong Jie, Zhou Gang, Zhang Qiuping, Gao Qingping, Zhang Kejian, Qiao Li, Alfred E. Chang, Jin Youxin, and Tan Jinquan 6723 E2-2 Regulates the Expansion of Pro-B Cells and Follicular versus Marginal Zone Decisions Ingela Wikstro¨m, Johan Forssell, Mario Goncalves, Francesco Colucci, and Dan Holmberg ϩ 6730 Human Bone Marrow: A Reservoir for “Enhanced Effector Memory” CD8 T Cells with Potent Recall Function Xiaoyu Zhang, Haidong Dong, Wei Lin, Stephen Voss, Lucinda Hinkley, Melissa Westergren, Guoliang Tian, Daniel Berry, David Lewellen, Richard G. Vile, Lieping Chen, Donna L. Farber, and Scott E. Strome 6738 CD8 T Cell Recall Responses Are Regulated by the Tissue Tropism of the Memory Cell and Pathogen Kimberly D. Klonowski, Amanda L. Marzo, Kristina J. Williams, Seung-Joo Lee, Quynh-Mai Pham, and Leo Lefranc¸ois ϩ ϩ 6747 CD4 T Cells in the Absence of the CD8 Cytotoxic T Cells Are Critical and Sufficient for NKT Cell-Dependent Tumor Rejection Changwan Hong, Hyunji Lee, Mihwa Oh, Chang-Yuil Kang, Seokmann Hong, and Se-Ho Park 6758 Hepatitis C Virus (HCV) Core Protein-Induced, Monocyte-Mediated Mechanisms of Reduced IFN-␣ and Plasmacytoid Dendritic Cell Loss in Chronic HCV Infection Angela Dolganiuc, Serena Chang, Karen Kodys, Pranoti Mandrekar, Gennadiy Bakis, Maureen Cormier, and Gyongyi Szabo 6769 Melan-A/MART-1-Specific CD4 T Cells in Melanoma Patients: Identification of New Epitopes and Ex Vivo Visualization of Specific T Cells by MHC Class II Tetramers Gilles Bioley, Camilla Jandus, Sandra Tuyaerts, Donata Rimoldi, William W. Kwok, Daniel E. Speiser, Jean-Marie Tiercy, Kris Thielemans, Jean-Charles Cerottini, and Pedro Romero 6780 T Regulatory and Primed Uncommitted CD4 T Cells Express CD73, Which Suppresses Effector CD4 T Cells by Converting 5Ј-Adenosine Monophosphate to Adenosine James J. Kobie, Pranav R. Shah, Li Yang, Jonathan A. Rebhahn, Deborah J. Fowell, and Tim R. Mosmann 6787 Activin A Functions as a Th2 Cytokine in the Promotion of the Alternative Activation of Macrophages Kenji Ogawa, Masayuki Funaba, Yan Chen, and Masafumi Tsujimoto Downloaded from ϩ 6795 The Wild-Type Sequence (wt) p5325–35 Peptide Induces HLA-DR7 and HLA-DR11-Restricted CD4 Th Cells Capable of Enhancing the Ex Vivo Expansion and Function of Anti-wt p53264–272 Peptide ϩ CD8 T Cells Daisuke Ito, Andreas Albers, Yong Xiang Zhao, Carmen Visus, Ettore Appella, Theresa L. Whiteside, and Albert B. DeLeo http://www.jimmunol.org/ 6804 TCR␣ Genes Direct MHC Restriction in the Potent Human T Cell Response to a Class I-Bound Viral Epitope John J. Miles, Natalie A. Borg, Rebekah M. Brennan, Fleur E. Tynan, Lars Kjer-Nielsen, Sharon L. Silins, Melissa J. Bell, Jacqueline M. Burrows, James McCluskey, Jamie Rossjohn, and Scott R. Burrows 6815 Fc Receptor Homolog 3 Is a Novel Immunoregulatory Marker of Marginal Zone and B1 B Cells Woong-Jai Won, Jeremy B.