Supplementary Table 3: Genes only influenced by X10 Illumina ID Gene ID Entrez Gene Name Fold change compared to vehicle 1810058M03RIK -1.104 2210008F06RIK 1.090 2310005E10RIK -1.175 2610016F04RIK 1.081 2610029K11RIK 1.130 381484 Gm5150 predicted gene 5150 -1.230 4833425P12RIK -1.127 4933412E12RIK -1.333 6030458P06RIK -1.131 6430550H21RIK 1.073 6530401D06RIK 1.229 9030607L17RIK -1.122 A330043C08RIK 1.113 A330043L12 1.054 A530092L01RIK -1.069 A630054D14 1.072 A630097D09RIK -1.102 AA409316 FAM83H family with sequence similarity 83, member H 1.142 AAAS AAAS achalasia, adrenocortical insufficiency, alacrimia 1.144 ACADL ACADL acyl-CoA dehydrogenase, long chain -1.135 ACOT1 ACOT1 acyl-CoA thioesterase 1 -1.191 ADAMTSL5 ADAMTSL5 ADAMTS-like 5 1.210 AFG3L2 AFG3L2 AFG3 ATPase family gene 3-like 2 (S. cerevisiae) 1.212 AI256775 RFESD Rieske (Fe-S) domain containing 1.134 Lipo1 (includes AI747699 others) lipase, member O2 -1.083 AKAP8L AKAP8L A kinase (PRKA) anchor protein 8-like -1.263 AKR7A5 -1.225 AMBP AMBP alpha-1-microglobulin/bikunin precursor 1.074 ANAPC2 ANAPC2 anaphase promoting complex subunit 2 -1.134 ANKRD1 ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 1.314 APOA1 APOA1 apolipoprotein A-I -1.086 ARHGAP26 ARHGAP26 Rho GTPase activating protein 26 -1.083 ARL5A ARL5A ADP-ribosylation factor-like 5A -1.212 ARMC3 ARMC3 armadillo repeat containing 3 -1.077 ARPC5 ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -1.190 activating transcription factor 4 (tax-responsive enhancer element ATF4 ATF4 B67) 1.481 AU014645 NCBP1 nuclear cap binding protein subunit 1, 80kDa 1.158 AV028368 TMEM201 transmembrane protein 201 1.273 BC013529 C6orf72 chromosome 6 open reading frame 72 -1.266 BC018242 LPPR2 lipid phosphate phosphatase-related protein type 2 1.095 BC018507 KIAA0947 KIAA0947 1.100 BC025546 FTSJD1 FtsJ methyltransferase domain containing 1 1.134 BC039210 PIEZO1 piezo-type mechanosensitive ion channel component 1 1.354 BNC1 BNC1 basonuclin 1 1.268 BSN BSN bassoon (presynaptic cytomatrix protein) 1.103 C130035G06RIK 1.105 C130037I06RIK 1.063 C130080K17RIK -1.065 C230098O21RIK -1.116 C3 NAD+ -1.608 CAMSAP1 CAMSAP1 calmodulin regulated spectrin-associated protein 1 1.071 CASP7 CASP7 caspase 7, apoptosis-related cysteine peptidase -1.130 CCDC28B CCDC28B coiled-coil domain containing 28B -1.129 CCDC92 CCDC92 coiled-coil domain containing 92 -1.221 CCL9 -1.381 CCT3 CCT3 chaperonin containing TCP1, subunit 3 (gamma) 1.223 CD274 CD274 CD274 molecule -1.321 CD300A CD300A CD300a molecule -1.077 CDK2AP2 CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -1.152 CDV3 CDV3 CDV3 homolog (mouse) 1.151 CENPA CENPA centromere protein A -1.196 CHAC1 CHAC1 ChaC, cation transport regulator homolog 1 (E. coli) 1.995 CHCHD10 CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -1.565 CHCHD4 CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 1.281 CIRH1A CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 1.288 CLTA CLTA clathrin, light chain A -1.250 CNR2 CNR2 cannabinoid receptor 2 (macrophage) -1.108 COP9 constitutive photomorphogenic homolog subunit 7A COPS7A COPS7A (Arabidopsis) 1.194 CRELD1 CRELD1 cysteine-rich with EGF-like domains 1 -1.147 CTPS CTPS CTP synthase 1.177 CXCL16 CXCL16 chemokine (C-X-C motif) ligand 16 -1.319 CYB561D1 CYB561D1 cytochrome b-561 domain containing 1 -1.073 CYB5B CYB5B cytochrome b5 type B (outer mitochondrial membrane) 1.210 CYP4F13 -1.311 CYTH4 CYTH4 cytohesin 4 -1.207 D0H8S2298E 1.177 D10ERTD610E -1.165 D130007C19RIK -1.095 D7BWG0611E -1.105 D930046M13RIK 1.133 DALRD3 DALRD3 DALR anticodon binding domain containing 3 -1.212 DCLK2 DCLK2 doublecortin-like kinase 2 1.122 DCN1, defective in cullin neddylation 1, domain containing 3 (S. DCUN1D3 DCUN1D3 cerevisiae) 1.081 DENND4B DENND4B DENN/MADD domain containing 4B 1.135 DHX58 DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 -1.239 DKK3 DKK3 dickkopf 3 homolog (Xenopus laevis) -1.280 DMAP1 DMAP1 DNA methyltransferase 1 associated protein 1 -1.259 DTX3L DTX3L deltex 3-like (Drosophila) -1.230 DYNC1LI2 DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 1.239 E030010A14RIK -1.106 E030030K01RIK 1.134 E530018B05RIK -1.057 EARS2 EARS2 glutamyl-tRNA synthetase 2, mitochondrial (putative) 1.158 EEF1E1 EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 1.185 EEF1G EEF1G eukaryotic translation elongation factor 1 gamma 1.232 EHHADH EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -1.112 EIF4E EIF4E eukaryotic translation initiation factor 4E 1.118 ENPP1 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -1.120 ETHE1 ETHE1 ethylmalonic encephalopathy 1 -1.207 EXT1 EXT1 exostosin 1 1.300 FAHD2A FAHD2A fumarylacetoacetate hydrolase domain containing 2A -1.079 FBXW17 -1.157 FBXW5 FBXW5 F-box and WD repeat domain containing 5 -1.176 FKBP1B FKBP1B FK506 binding protein 1B, 12.6 kDa -1.158 FAD1 flavin adenine dinucleotide synthetase homolog (S. FLAD1 FLAD1 cerevisiae) -1.133 FNBP1 FNBP1 formin binding protein 1 -1.181 GAB3 GAB3 GRB2-associated binding protein 3 -1.075 GBP3 GBP3 guanylate binding protein 3 -1.328 GBP6 GBP6 guanylate binding protein family, member 6 -1.134 GCK GCK glucokinase (hexokinase 4) 1.116 GLUD1 GLUD1 glutamate dehydrogenase 1 -1.240 GM528 -1.070 GM684 1.083 GMDS GMDS GDP-mannose 4,6-dehydratase -1.220 GNL2 GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 1.191 GPR120 O3FAR1 omega-3 fatty acid receptor 1 -1.128 GPS2 GPS2 G protein pathway suppressor 2 -1.145 GPX1 (includes GPX1 EG:14775) glutathione peroxidase 1 -1.244 GRP1 (general receptor for phosphoinositides 1)-associated scaffold GRASP GRASP protein -1.199 GSPT1 GSPT1 G1 to S phase transition 1 1.186 GYS3 1.092 H2-KE6 -1.290 HBEGF HBEGF heparin-binding EGF-like growth factor 1.329 HEATR1 HEATR1 HEAT repeat containing 1 1.151 HES6 HES6 hairy and enhancer of split 6 (Drosophila) -1.218 HHAT HHAT hedgehog acyltransferase 1.162 HIST2H2BE (includes HIST1H2BF others) histone cluster 2, H2be -1.403 HIST1H2BH/ HIST1H2BH HIST1H2BO histone cluster 1, H2bh -1.486 HNRPA1 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1.157 HOXA4 HOXA4 homeobox A4 1.231 HRMT1L6 PRMT6 protein arginine methyltransferase 6 1.123 HS3ST3B1 HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 1.062 HS6ST1 HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.276 IDB2 -1.164 IFT88 IFT88 intraflagellar transport 88 homolog (Chlamydomonas) -1.193 IGTP -1.450 IIGP2 -1.582 IL11 IL11 interleukin 11 1.136 INPP5K INPP5K inositol polyphosphate-5-phosphatase K -1.189 IPPK IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 1.132 IQCE IQCE IQ motif containing E -1.226 IRF1 (includes IRF1 EG:16362) interferon regulatory factor 1 -1.195 IRF7 IRF7 interferon regulatory factor 7 -1.183 KCNK6 KCNK6 potassium channel, subfamily K, member 6 -1.131 KLC2 KLC2 kinesin light chain 2 1.100 KLF16 KLF16 Kruppel-like factor 16 1.141 KLF6 KLF6 Kruppel-like factor 6 -1.176 KLHDC8B KLHDC8B kelch domain containing 8B 1.062 LARP-PENDING 1.120 LAT2 LAT2 linker for activation of T cells family, member 2 -1.170 LHFPL2 LHFPL2 lipoma HMGIC fusion partner-like 2 1.298 LOC100044298 -1.222 LOC100045708 1.148 LOC100045981 -1.307 LOC100046163 1.116 LOC100046608 -1.087 LOC100047260 1.336 LOC100048554 -2.246 LOC223672 -1.259 LOC230253 1.149 LOC230592 1.164 LOC240672 1.316 LOC277313 -1.125 LOC331336 -1.062 LOC380854 1.075 LOC381466 -1.119 LOC381607 1.091 LOC382866 1.106 LOC383836 1.120 LOC384206 1.179 LOC386553 1.166 LOC666238 1.064 LOC670044 -1.117 LTB4R1 -1.338 LTBP2 LTBP2 latent transforming growth factor beta binding protein 2 1.053 LTC4S LTC4S leukotriene C4 synthase -1.273 LYCAT LCLAT1 lysocardiolipin acyltransferase 1 1.106 MAF1 (includes MAF1 EG:315093) MAF1 homolog (S. cerevisiae) -1.282 MAML1 MAML1 mastermind-like 1 (Drosophila) 1.167 MAN2C1 MAN2C1 mannosidase, alpha, class 2C, member 1 -1.172 MAST3 MAST3 microtubule associated serine/threonine kinase 3 -1.218 MCOLN2 MCOLN2 mucolipin 2 -1.121 MED27 MED27 mediator complex subunit 27 1.179 MFSD1 MFSD1 major facilitator superfamily domain containing 1 -1.276 MKI67IP MKI67IP MKI67 (FHA domain) interacting nucleolar phosphoprotein 1.255 MOCOS MOCOS molybdenum cofactor sulfurase -1.123 MRPL43 MRPL43 mitochondrial ribosomal protein L43 -1.173 MS4A6D -1.343 MSLN MSLN mesothelin 1.194 MYO1G MYO1G myosin IG -1.415 NAPRT1 NAPRT1 nicotinate phosphoribosyltransferase domain containing 1 -1.075 NCF4 NCF4 neutrophil cytosolic factor 4, 40kDa -1.474 NCKAP1L NCKAP1L NCK-associated protein 1-like -1.232 NECAP1 NECAP1 NECAP endocytosis associated 1 1.132 NIT2 NIT2 nitrilase family, member 2 -1.074 NKIRAS2 NKIRAS2 NFKB inhibitor interacting Ras-like 2 1.181 NOD1 NOD1 nucleotide-binding oligomerization domain containing 1 -1.325 NOL1 NOP2 NOP2 nucleolar protein homolog (yeast) 1.259 OASL2 -1.210 OCIAD2 OCIAD2 OCIA domain containing 2 -1.194 OGFRL1 OGFRL1 opioid growth factor receptor-like 1 -1.246 OLFR1390 1.081 OLFR66 1.084 P2RY6 P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 -1.210 PAIP2B PAIP2B poly(A) binding protein interacting protein 2B 1.184 PARP16 PARP16 poly (ADP-ribose) polymerase family, member 16 1.103 PCDHGA4 PCDHGA4 protocadherin gamma subfamily A, 4 1.072 PDE6D PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -1.303 PICALM PICALM phosphatidylinositol binding clathrin assembly protein 1.212 PIGZ PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z -1.140 PIK3IP1 PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -1.205 PIRA4 -1.140 PODXL PODXL podocalyxin-like 1.180 PPAPDC1 PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A 1.261 PPIL1 PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 1.275 PRDX6-RS2 1.061 PRPF4 PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast) 1.144 PTCD2 PTCD2 pentatricopeptide repeat domain 2 1.112 PWWP2B PWWP2B PWWP domain containing 2B 1.093 R3HDM2 R3HDM2 R3H domain containing 2 1.092 RAB32 RAB32 RAB32, member RAS oncogene family -1.214 RAB3D RAB3D RAB3D, member RAS oncogene family -1.183 RASL2-9 -1.078 RBM13 MAK16 MAK16 homolog (S.