An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000021125Cyc: Escherichia coli servovar O157:H7 str. EC4115 Cellular Overview Connections between pathways are omitted for legibility. 4-amino-4- deoxy-α-L- arabinopyranosyl sn-glycerol a dicarboxylate an amino an amino ditrans,octacis lipid II (meso L-tartrate 3-phosphate γ-butyrobetaine acid acid glutathione O-acetyl-L-serine O-acetyl-L-serine 1-(β-D phosphate an amino an amino D-cellobiose a dipeptide an aromatic -undecaprenyl diaminopimelate phosphate phosphate 3-(3- an amino an amino an amino an amino an amino an amino an amino an amino thiamine cys cys ribofuranosyl) Fe 2+ spermidine glutathione succinate sn-glycerol L-carnitine N,N'- acid acid salicin amino acid phosphate containing) galactarate N-acetylneuraminate phosphate phosphate (S)-lactate D-sorbitol D-glucosamine D-gluconate D-gluconate D-gluconate melibiose 3-phenylpropanoate hydroxyphenyl) acid acid acid acid acid acid acid acid a dipeptide a dipeptide diphosphate nicotinamide enterobactin cys 3-phosphate predicted diacetylchitobiose propanoate arbutin predicted predicted ABC predicted predicted predicted ABC ABC transporter ABC ABC ATP-driven RS00910 transporter RS11005 RS19155 RS17110 RS04620 RS07605 RS03795 RS11815 RS05645 RS21820 RS22125 RS28820 RS27260 RS23565 transporter RS24050 RS21435 RS24700 RS19805 RS04210 RS17000 of sn- RS00770 RS23490 RS23630 RS28885 RS12530 RS27930 RS18930 RS02645 RS23300 RS09975 RS03330 RS13670 RS13880 RS04480 RS05210 RS17355 transporter transporter RS21895 RS05710 RS19860 RS24385 RS04355 transporter RS01140 of glutathione of phosphate glycerol 3- of an of an of a dipeptide amino acid amino acid 4-amino-4- lipid II (meso phosphate O-acetyl-L-serine O-acetyl-L-serine β 2+ spermidine an amino an aromatic thiamine deoxy-α-L- 1-( -D diaminopimelate Fe glutathione phosphate phosphate D-sorbitol D-glucosamine sn-glycerol N,N'- 3-(3- D-cellobiose 6'-phosphate cys cys succinate galactarate N-acetylneuraminate phosphate phosphate (S)-lactate L-carnitine D-gluconate D-gluconate D-gluconate melibiose 3-phenylpropanoate an amino an amino an amino an amino acid an amino an amino an amino an amino an amino a dipeptide a dipeptide amino acid diphosphate arabinopyranosyl ribofuranosyl) containing) enterobactin cys 6-phosphate 6-phosphate 3-phosphate diacetylchitobiose hydroxyphenyl) salicin 6-phosphate nicotinamide L-tartrate γ-butyrobetaine 6'-phosphate propanoate acid acid acid acid acid acid acid acid acid arbutin-6-phosphate glutathione ditrans,octacis phosphate a dipeptide sn-glycerol a dicarboxylate an amino an amino -undecaprenyl acid acid phosphate 3-phosphate Aromatic Compound Biosynthesis C1 Compound Utilization 6 γ 2457 32 N 6 -dimethylallyladenosine 37 a peptidoglycan dimer a [protein]- an O - L-alanyl- -D- a peptidoglycan sn-glycero-3- uridine UDP-N-acetyl- a uridine adenosine a [protein]-L- GDP-α-D- biotin biosynthesis I Cofactor, Carrier, and Vitamin Biosynthesis a sulfurated + an L-asparaginyl- a lipid II an L-cysteinyl- 5 superpathway of demethylmenaquinol-8 biosynthesis I superpathway of tetrahydrofolate biosynthesis molybdenum cofactor biosynthesis Fermentation mixed acid fermentation Entner-Doudoroff pathway I Carbohydrate Degradation and Assimilation cob(II)inamide with pentapeptide methylguanine glutamyl-meso-2,6- dimer (E. faeciums) phospho-N- NADPH NAD in 23S rRNA α-D-muramoyl- in tRNA 2',3'-cyclic a [glutamine- glutamate-O mannose [2Fe-2S] iron-sulfur superpathway of adenosylcobalamin salvage from cobinamide I superpathway of thiamine diphosphate biosynthesis I NAD salvage 5-methoxy-6-methylbenzimidazolyl Tetrapyrrole Biosynthesis D-galactosamine L-rhamnose degradation II D-arabinose degradation I trehalose degradation [sulfur carrier] in tRNA ATP L-cysteine ATP [tRNA Asn ] ATP [tRNA Cys ] ATP enterobactin biosynthesis D-galactose degradation I (Leloir pathway) L-rhamnose degradation I in DNA diaminopimeloyl- UDP-N-acetyl- a tRNA precursor (arachidonoyl) ribosomal large γ ribosomal large monophosphate synthetase]- -methyl-ester cluster biosynthesis pathway IV (from adenosylcobamide biosynthesis 4-hydroxyphenylpyruvate chorismate biosynthesis I dipicolinate biosynthesis and N-acetyl-D- VI (periplasmic) formaldehyde oxidation stems (meso- CTP L-alanyl- -D- 2',3'-cyclic-nucleotide biotin D-glucopyranose D-alanine α-D-muramate ethanolamine subunit pseudouridine subunit pseudouridine L-tyrosine a malonyl-[acp] chorismate nicotinamide riboside) from adenosylcobinamide-GDP biosynthesis tetrapyrrole biosynthesis phosphoenolpyruvate galactosamine degradation α-L- D-arabinopyranose II (glutathione-dependent) diaminopimelate serine-type D-Ala-D- glutamyl-meso-2,6- 2'-phosphodiesterase: serine-type D-Ala-D- GDP-mannose cob(II)inamide 1-(β-D D-erythrose 6-phosphate β-D-galactopyranose L-rhamnopyranose methylated-DNA-- NAD(P)(+) synthase D: synthase D: malonyl-[acyl- GTP cys ATP GTP 5-methoxy-6- chorismate siroheme biosynthesis N-acetyl-D- rhamnopyranose α,α-trehalose succinate cob(I)yrinic acid containing) Ala carboxypeptidase diaminopimeloyl- ECH74115_RS28425 peptidyl-tRNA Ala carboxypeptidase peptidyl-tRNA chemotaxis mannosyl hydrolase: L-cysteine desulfurase ribofuranosyl) 4-phosphate I (from glutamate) glucose-6-phosphate [protein]-cysteine S- transhydrogenase ECH74115_RS19240 ECH74115_RS19240 glutamine-synthetase carrier protein] O- isochorismate cob(I)yrinic acid methylbenzimidazole tyr asp galactosamine L-fucose isomerase: formaldehyde dehydrogenase a,c-diamide UDP-N- multifunctional CCA DacD: glycerophosphodiester D-alanyl-D-alanine hydrolase: DacD: hydrolase: response regulator ECH74115_RS15035 bifunctional biotin- nicotinamide nicotinate-nucleotide-- isochorismate 3-deoxy-7- phosphoenolpyruvate 1-dehydrogenase: aldose epimerase: L-rhamnose methyltransferase: (Re/Si-specific): multifunctional CCA adenylyltransferase: methyltransferase BioC: synthase MenF: a,c-diamide cysteine desulfurase: GTP 3',8'- multifunctional bifunctional pyruvate kinase I: 6-phosphate ECH74115_RS20320 hydrophobic membrane adenosyltransferase: N-acetylmuramoyl-L- acetylmuramate:L- tRNA nucleotidyl ECH74115_RS14490 phosphodiesterase: bifunctional tRNA bifunctional tRNA ECH74115_RS08790 ECH74115_RS14490 ECH74115_RS08790 protein-glutamate -[acetyl-CoA- cysteine desulfurase: GTP cyclohydrolase molybdopterin-synthase dimethylbenzimidazole synthase MenF: aspartate/ phosphoheptulonate glu uroporphyrinogen-III carboxylase: ECH74115_RS13175 ECH74115_RS31425 L-rhamnofuranose mutarotase: ECH74115_RS10195 ECH74115_RS11830 tRNA nucleotidyl ECH74115_RS21765 GDP-mannose ECH74115_RS05025 ECH74115_RS17145 adenosyltransferase: ECH74115_RS12235 cyclase: transcriptional aspartokinase ECH74115_RS12215 N-acetylglucosamine- trehalase: treF anchor subunit: ECH74115_RS04470 alanine amidase AmiA: alanyl-gamma-D- transferase/2'3'-cyclic ECH74115_RS23685 pseudouridine(32) pseudouridine(32) methylesterase: carboxylase] ligase/ a malonyl-[acp] ECH74115_RS12235 I FolE: adenylyltransferase cys phosphoribosyltransferase: ECH74115_RS17145 tyrosine/aromatic synthase: siroheme synthase: ECH74115_RS26930 6-phospho [+ 3 isozymes] ECH74115_RS26600 D-ribulose serine-type D-Ala-D- ECH74115_RS11835 serine-type D-Ala-D- transferase/2'3'-cyclic aminoacyl-tRNA serine-type D-Ala-D- aminoacyl-tRNA mannosyl hydrolase: isochorismate [+ 2 isozymes] moaA regulator/nicotinamide- II/homoserine pyruvate kinase: 6-phosphate β S-(hydroxymethyl) ECH74115_RS04425 bifunctional DNA- glutamyl- meso- phosphodiesterase/ synthase/ribosomal synthase/ribosomal ECH74115_RS13335 biotin operon methyl ester [+ 2 isozymes] ECH74115_RS16560 ECH74115_RS09780 MoeB: 5-methoxy-6-ECH74115_RS14350 aminotransferase: 3-deoxy-ECH74115_RS19270 ECH74115_RS23290 D-glucono- -L- cob(I)yrinic acid ECH74115_RS18430 Ala carboxypeptidase: glycerophosphodiester Ala carboxypeptidase phosphodiesterase/ hydrolase: Ala carboxypeptidase: hydrolase: ECH74115_RS15130 synthase EntC: 7,8- an [L-cysteine (8S)-3',8-cyclo-7,8- nucleotide isochorismate dehydrogenase ECH74115_RS13190 α-D-galactopyranose deacetylase: glutathione binding transcriptional diaminopimelate ligase: 2'nucleotidase/ soluble pyridine large subunit large subunit a [glutamine repressor BirA: cob(I)yrinic acid a ThiS sulfur- ECH74115_RS05290 cysteine desulfurase: methylbenzimidazole ECH74115_RS05845 D-arabino- an L-glutamyl- uroporphyrinogen-III 1,5-lactone rhamnopyranose L-fuculokinase: aldose 1-epimerase: tRNA (N6-isopentenyl a,c-diamide [+ 4 isozymes] ECH74115_RS22420 phosphodiesterase: DacD: 2'nucleotidase/ ECH74115_RS01535 ECH74115_RS22420 ECH74115_RS01535 beta-ketoacyl-[acyl- an S-sulfanyl-[L- ECH74115_RS03800 dihydroneopterin desulfurase]-S- a carboxy- dihydroguanosine adenylyltransferase/ synthase EntC: II: metL ECH74115_RS22175 regulator/O6- ECH74115_RS28520 phosphatase: nucleotide pseudouridine pseudouridine synthetase]-O ECH74115_RS27025 a,c-diamide carrier protein ECH74115_RS12235 ribotide phosphate aromatic amino heptulosonate [tRNA Glu ] C-methyltransferase: oxaloacetate ECH74115_RS20325 ECH74115_RS18970 S-(hydroxymethyl) adenosine(37)-C2)- adenosyltransferase: ECH74115_RS16995 ECH74115_RS14490 phosphatase: