Meeting Program and Abstracts ASCI / AAP Joint Meeting 2015 April 24 – 26, 2015 The Fairmont Chicago Chicago, Illinois www.jointmeeting.org The ASCI / AAP conference is jointly provided by Boston University School of Medicine and ASCI / AAP. www.jointmeeting.org Special Events at the 2015 ASCI/AAP Joint Meeting Friday, April 24 Saturday, April 25 ASCI President’s Reception ASCI Reception for New Members (Invitation only) and Young Physician-Scientist 6:15 – 7:15 p.m. Poster Session Gold Room (Invited guests and members of the ASCI and AAP only) 6:00 – 8:00 p.m. ASCI Annual Dinner & Gold Room New Member Induction Ceremony Speaker: Griffin P. Rodgers, MD, MACP (Ticketed guests only) National Institute of Diabetes, Digestive and 7:30 – 9:45 p.m. Kidney Diseases Moulin Rouge, 1st Floor Inspiring the Next Generation of Physician-Scientists AAP Annual Reception & Dinner Speaker: Robert J. Lefkowitz, MD 7:00 – 10:00 p.m. Duke University Imperial Ballroom From Lake Wobegon to Stockholm AAP President’s Dinner Speaker: Peter Agre, MD (Invitation only) Johns Hopkins University 7:00 – 9:00 p.m. (Off site) APSA Dinner 7:30 – 9:00 p.m. APSA Welcome Reception & Moulin Rouge Presidential Address Life as a Physician-Scientist: The Road from Here to 9:00 p.m. – Midnight There and Everywhere John Hancock Center (Off site) Speaker: Liise-anne Pirofski, MD Albert Einstein College of Medicine Speaker: Michael Guo APSA President Dessert Reception (Open to all attendees) 10:00 p.m. – Midnight Imperial Foyer www.jointmeeting.org 2 www.jointmeeting.org General Information Accreditation and Learning Objectives Credit Designation As a result of this meeting, participants will be able to: This activity has been planned and implemented in accordance • Discuss important recent advances in the scientific basis of with the Essential Areas and Policies of the Accreditation Council disease and therapy for Continuing Medical Education (ACCME) through the joint • Describe novel strategies to address challenges to the providership of the Boston University School of Medicine, the physician-scientist American Society for Clinical Investigation and the Association • Evaluate the roles that improved understanding of these of American Physicians. Boston University School of Medicine advances and strategies can play in the potential treatment of is accredited by the ACCME to provide continuing medical human disease education for physicians. Boston University School of Medicine designates this live activity for a maximum of 9 AMA PRA Category 1 Credits™. Physicians Target Audience should claim only the credit commensurate with the extent of Any physician-scientists, trainees, and students, across a their participation in the activity. broad range of specialties (Basic Research, Cardiology / Nurses and other health professionals will receive a Certificate Cardiovascular Research, Cell and Molecular Biology, Endocrine of Attendance. For information on applicability and acceptance, and Metabolism, Hematology, Immunology, Infectious Diseases, please consult your professional licensing board. Nephrology, Neurology, Pulmonology, others. Course Director Educational Need Edward Alexander, MD The Joint Meeting Planning Committee strives to represent Boston University School of Medicine the cutting edge of biomedical research and medicine. The Committee is especially interested in identifying gaps in knowledge that may exist in the target audience, which consists Program Planning Committee of physician-scientists, research scientists, clinicians and medical education professionals. The meeting also targets junior Committee Members: scientists and trainees, who benefit from close interaction with Paul Rothman, MD — AAP President senior colleagues. Johns Hopkins University The 2015 ASCI/AAP Joint Meeting program will feature lectures Stanley Lemon, MD — AAP President-Elect by accomplished researchers who will discuss state-of-the-art The University of North Carolina at Chapel Hill advances in their respective fields. The program is designed to foster in-depth discussions and close interactions among the Christine E. Seidman, MD — AAP Vice President meeting participants. Brigham and Women’s Hospital — Harvard Medical School DISCLAIMER: THESE MATERIALS AND ALL OTHER MATERIALS J. Larry Jameson, MD, PhD — AAP Immediate Past President PROVIDED IN CONJUNCTION WITH CONTINUING MEDICAL University of Pennsylvania Health System, Perelman School EDUCATION ACTIVITIES ARE INTENDED SOLELY FOR of Medicine PURPOSES OF SUPPLEMENTING CONTINUING MEDICAL Mukesh K. Jain, MD — ASCI President EDUCATION PROGRAMS FOR QUALIFIED HEALTH CARE Case Western Reserve University School of Medicine PROFESSIONALS. ANYONE USING THE MATERIALS Levi Garraway, MD, PhD — ASCI President-Elect ASSUMES FULL RESPONSIBILITY AND ALL RISK FOR THEIR Harvard Medical School, Dana-Farber Cancer Institute APPROPRIATE USE. TRUSTEES OF BOSTON UNIVERSITY MAKES NO WARRANTIES OR REPRESENTATIONS Peter Tontonoz, MD, PhD — ASCI Immediate Past President WHATSOEVER REGARDING THE ACCURACY, COMPLETENESS, University of California, Los Angeles, David Geffen School CURRENTNESS, NONINFRINGEMENT, MERCHANTABILITY OR of Medicine FITNESS FOR A PARTICULAR PURPOSE OF THE MATERIALS. IN NO EVENT WILL TRUSTEES OF BOSTON UNIVERSITY BE Lori Ennis — Executive Director AAP, LIABLE TO ANYONE FOR ANY DECISION MADE OR ACTION Ex Officio Committee Member TAKEN IN RELIANCE ON THE MATERIALS. IN NO EVENT SHOULD THE INFORMATION IN THE MATERIALS BE USED AS John Hawley — Executive Director ASCI, A SUBSTITUTE FOR PROFESSIONAL CARE. Ex Officio Committee Member 3 www.jointmeeting.org General Information Full Disclosure Policy Affecting Disclosure of Unlabeled/ CME Activities Investigational Uses of Drugs Boston University School of Medicine asks all individuals or Devices involved in the development and presentation of Continuing Medical Education (CME) activities to disclose all relationships None of the faculty has indicated that they plan to discuss with commercial interests. This information is disclosed to CME unlabeled or investigational uses of products or devices. activity participants. Boston University School of Medicine has procedures to resolve any apparent conflicts of interest. In addition, faculty members are asked to disclose when any 2015 Joint Meeting Program unapproved use of pharmaceuticals and devices is being discussed. It is understood that presentations must give a Committee Disclosures balanced view of therapeutic options. Faculty use of generic The following program committee members indicated that they names will contribute to this impartiality. The speaker will have financial relationships to disclose. They have agreed to make every effort to ensure that data regarding the company’s disclose this to participants. All other named program committee products (or competing products) are objectively selected and members in this program have completed financial disclosure presented, with balanced discussion of prevailing information on forms and had no financial relationships to report. the product(s) and/or alternative treatments. First Last Disclosure Levi Garraway Foundation Medicine: co-founder, stockholder, and 2015 Joint Meeting Faculty consultant (myself) Novartis: sponsored research support and consultant (myself) Boehringer Disclosures Ingelheim: consultant (myself) The following faculty indicated that they have financial Paul Rothman Board Member Cancer Genetics Inc. relationships to disclose. They have agreed to disclose this Christine Seidman CES is a founder and owns shares in Myokardia to participants. All other named faculty in this program have Inc., a startup company that is developing completed financial disclosure forms and had no financial therapeutics that target the sarcomere. relationships to report. First Last Disclosure Richard Ehman President, CEO, equity holder, in Resoundant, Inc. Claiming CME Credit Jeffrey Friedman I am listed on the leptin patent and receive a portion Participants who wish to claim CME credit will receive a CME of the royalties Credit Claim Form and a Required Evaluation with conference Daniel Geschwind Consultant, Medical Advisory Board Novartis materials. In order to claim credit, these forms must be Consultant Advisory Board SynapDx completed and returned to the conference registration desk Gail Hecht Dannon - Scientific Advisory Board member or mailed to: Attention Erika Moy, The Kellen Company, Rudolf Jaenisch Fate Therapeutics - consultant Stemgent - consultant 111 Deer Lake Road, Deerfield, IL 60015 no later than May 25, 2015, in order to receive credit. Jeffrey Kline Consultant-- Janssen Pharma Grant support--NIH Consultant--Stago Diagnostica Mitchell Lazar Eli Lilly and Company (Board Member) Pfizer Inc. (Board Member) KDAC Therapeutics, Inc (Board Member) Janssen (Consultant) Merck Inc. (Grant Support) Jeffrey Leiden 1. Vertex Pharmaceuticals, Inc. - Chairman, CEO, President & shareholder 2. Quest Diagnostics - Director, shareholder 3. Claurs Ventures - Former Managing Director, Senior Advisor Stanley Lemon Merck - Consultant, research support AbbVie - Consultant, other Theravance - Consultant Alfred Sommer Just finished being a Director of Becton Dickenson. My “retirement” payout will span 10 years Craig Thompson Board of Directors: Merck, Charles River Laboratories, NY Genome Center; SAB/stock holder- Agios; CEO- MSKCC; SAB- MDA, City of Hope Victor Velculescu 1. Personal Genome Diagnostics (PGDx) : Founder/ BOD/Officer - Shareholder 2. Quintiles : Member of Sci. Ad. Board - Honorarium 4