SCHOLARSHIP REPORT BIOENGINEERING 2018 | 2019 Chair’s Message | 1 Quick Facts | 2 Honors | 4 Our Faculty | 5 We are a leader in experiential education and interdisciplinary research, focused on Engineering for Society Dear Colleagues and Students, The Department of Bioengineering is the newest department in Northeastern’s College of Engineering. Building on the success of its PhD program, BioE added BS and MS degree programs in the 2015 – 2016 academic year. We are now in an era of rapid growth with plans to double our faculty over the next three years and continue to increase as our student body expands. Our research into the fundamentals of cell and tissue engineering, biomedical device design, biomedical imaging and signal processing, biomechanics and biocomputing is providing a foundation on which a vibrant bioengineering community is developing—a community that spans the entire University. With over 50 affiliated faculty, the bioengineering department offers Sincerely, research opportunities that encompass the entire breadth of Lee Makowski biological and biomedical engineering. Department Chair Bioengineering Our co-op program is working with companies across the sector [email protected] to provide BioE students with a broad range of opportunities within the Boston biotech industry and beyond. Through the co-op program, we identify opportunities that make it possible for our students to work in research and development areas that most excite them. I invite you to learn more about our new and fast-growing Department of Bioengineering. Our Scholarship Report provides a window into the many activities of our faculty and the energy and breadth of their research. 1 QUICK Bioengineering FACTS Students RECENT HIRES Erel Levine PhD, Weizmann Institute of 616 Science 64 Herbert Levine TENURED/ PhD, Princeton University TENURE-TRACK Jiahe Li Including T/TT PhD, Cornell University Affiliated Faculty Sara Rouhanifard BS enrollment PhD, Albert Einstein College growth of Medicine 36% since 2017 Young Investigator Awards 4 Leading-edge Research New Institute for the National Academy Chemical Imaging of Member Living Systems Herbert Levine, University Led by Professor Distinguished Professor Heather Clark. See page 4 College of Engineering With 185 tenured/tenure- NSF CAREER Awards track faculty and 16 993 multidisciplinary research 48 Graduate Students centers and institutes with Placed on Co-op (2018-19) funding by eight federal Engineering Departments agencies, the College of STUDENTS ENROLLED Engineering is a leader in 5 experiential education and interdisciplinary research, YOUNG INVESTIGATOR with a focus on discovering Awards 8080 52% Graduate solutions to global challenges 90 1485 New MS (Fall 2018) to benefit society. 48% Undergraduate 675 New BS (Fall 2018) 2 FACULTY BY RESEARCH AREAS IMAGING, Samuel Chung Heather Clark INSTRUMENTATION, AND Qianqian Fang Mark Niedre SIGNAL PROCESSING Sara Rouhanifard Ambika Bajpayee BIOMECHANICS, Chiara Bellini Guohao Dai BIOTRANSPORT AND Jessica Oakes Harikrishnan Parameswaran MECHANOBIOLOGY Jeffery Ruberti Sandra Shefelbine Anand Asthagiri Chiara Bellini COMPUTATIONAL AND Erel Levine Herbert Levine SYSTEMS BIOLOGY Jessica Oakes Nikolai Slavov Eduardo Sontag Anand Asthagiri Mark Niedre Ambika Bajpayee Harikrishnan Parameswaran Molecular, Cell, and Samuel Chung Sara Rouhanifard Guohao Dai Jeffrey Ruberti Tissue Engineering Jiahe Li Eduardo Sontag Lee Makowski 3 FACULTY HONORS AND AWARDS Assistant FACULTY HONORS AND AWARDS Professor STUDENT HONORS AND AWARDS Ambika Erica Wagner, Bajpayee E’20, earned (PI) and the prestigious Jiahe Li Barry (co-PI) were awarded a $628K NIH Goldwater Trailblazer R21 grant for New and Scholarship, Early Stage Investigators from the the United National Institute of Biomedical States’ premier Imaging and Bioengineering (NIBIB) award for Assistant Professors Jessica for “Anti-Catabolic Drug Anchored outstanding young researchers in Oakes and Chiara Bellini are Cationic Exosomes For Cartilage STEM fields. principal investigators for a $1.5M Targeting And Repair.” collaborative award from the Congtin Justin Assistance to Firefighters Grant Professor Nguyen,E’19, Program, administered through Heather received the Department of Homeland Clark directs the German Security (DHS) Federal Emergency Northeastern’s Academic Management Agency’s (FEMA) new Institute Exchange Grant Programs Directorate, for Chemical Service for examining the “Health Imaging of (DAAD) Study Consequences Following Acute Living Systems, Scholarship, and Chronic Firefighter Exposure which focuses which will support his Master of to Wildland Fire Smoke.” on finding Science program in Regenerative ways to image Biology and Medicine at Associate the chemistry of our bodies. Germany’s Technische Universität Professor She was also awarded a $1.5M Dresden (TUD), one of that nations’ Guohao Dai grant from the National Institute finest universities in the sciences was selected as of Neurological Disorders and and engineering. a Fellow of the Stroke for “Nanosensors for American Heart Chemical Imaging of Acetylcholine Minhal Using MRI.” Association Ahmed, E’19, (FAHA) by was selected the Council Assistant as a George of Basic Professor J. Mitchell Cardiovascular Sciences of AHA. Nikolai Scholar, which Slavov has sends future Assistant Professors Ambika developed a American data-driven Bajpayee and Nikolai leaders to technique the island of Ireland for a year Slavov were each recipients to detect of graduate study. He was also of a Sanofi iAward, created more than named the winner of the Harold D. 2,000 proteins in a single cell. His to promote scientific Hodgkinson Achievement Award single cell mass spectroscopy for 2019, one of the highest honors breakthroughs. Bajpayee’s now offers a cheaper and faster a senior can receive. project is “Exosomes for technique that allows researchers to analyze a much larger number Kritika Singh, oral delivery of Foxo1 SiRNA of single cells and results in much E’20, was for treatment of Type 1 more accurate data. To further Mark Niedre named a the research, Slavov is working diabetes,” and Slavov’s 2019 Truman Harikrishnan Parameswaran collectively with another 200 Scholar, a project is “Developing a labs from various countries in the Sara Rouhanifard United States’ technology platform for Human Atlas Project, an effort to premier Jeffrey Ruberti identify all of the different single discovering biomarkers and graduate cells comprising the human body. Eduardo Sontag fellowship drug targets.” His part of the project is supported for those who intend to devote by the Chan Zuckerberg Initiative. their careers to serving the public good. 4 FACULTY MANSOOR AMIJI ANAND ASTHAGIRI University Distinguished Professor, Professor Associate Professor, Bioengineering; of Pharmaceutical Sciences, Chemical affiliated faculty, Chemical Engineering Engineering; affiliate faculty, Bioengineering PhD, Massachusetts Institute of PhD, Purdue University, 1992 Technology, 2000 coe.northeastern.edu/people/amiji- coe.northeastern.edu/people/ mansoor asthagiri-anand Scholarship focus: polymeric Scholarship focus: cell and tissue biomaterials, drug delivery systems, nanomedical engineering, quantitative principles of cancer cell biology technologies and developmental biology Honors and awards: Fellow, American Association of Pharmaceutical Scientists (AAPS); Fellow, Controlled SELECTED PUBLICATIONS Release Society; Charivate Analytics Highly Cited D.F. Milano, R.J. Natividad, Y. Saito, C.Y. Luo, Author (top 1%); Purdue University School of Pharmacy S.K. Muthuswamy, A.R. Asthagiri Distinguished Alumni Award Positive Quantitative Relationship Between EMT and Contact-Initiated Sliding on Fiber-Like Tracks, Biophysical SELECTED PUBLICATIONS Journal, 111(7), 2016, 1569-1574 Y. Cho, L. Milane, M. Amiji D.F. Milano, N.A. Ngai, S.K. Muthuswamy, A.R. Asthagiri Genetic and Epigenetic Strategies for Advancing Ovarian Regulators of Metastasis Modulate the Migratory Cancer Immunotherapy, Expert Opinion on Biological Response to Cell Contact Under Spatial Confinement, Therapy, 19(6), 2019, 547-560 Biophysical Journal, 110(8), 2016, 1886-1895 S. Iyer, A. Radwan, A. Hafezi-Moghadam, P. Malyala, D.I. Walsh III, M.L. Lalli, J.M. Kassas, A.R. Asthagiri, M. Amiji S.K. Murthy Long-Acting Intraocular Delivery Strategies for Biological Cell Chemotaxis on Paper for Diagnostics, Analytical Therapy of Age-Related Macular Degeneration, Journal of Chemistry, 87(11), 2015, 5505-5510 Controlled Release, 296, 2019, 140-149 M.L. Lalli, A.R. Asthagiri D. Chen, S. Ganesh, W. Wang, M. Amiji Collective Migration Exhibits Greater Sensitivity but Role of surface Chemistry on Serum Protein Corona- Slower Dynamics of Alignment to Applied Electric Fields, Mediated Cellular Delivery and Gene Silencing with Lipid Cellular and Molecular Bioengineering, 8(2), 2015, Nanoparticles, Nanoscale, 11, 2019, 8760-8775 247-257 N.N. Parayath, A. Parikh, M. Amiji K. Blogovic, E.S. Gong, D.F. Milano, R.J. Natividad, Repolarization of Tumor-Associated Macrophages in A.R. Asthagiri a Genetically Engineered Non-Small Cell Lung Cancer Engineering Cell-Cell Signaling, Current Opinion in Model by Intraperitoneal Administration of Hyaluronic Biotechnology, 24(5), 2013, 940-947 Acid-Based Nanoparticles Encapsulating MicroRNA- K. Kushiro, A.R. Asthagiri 125b, Nano Letters, 18(6), 2018, 3571-3579 Modular Design of Micropattern Geometry Achieves Combinatorial Enhancements in Cell Motility, Langmuir, SELECTED RESEARCH PROJECTS 28(9), 2012, 4357-4362 Direct