THE NATIONAL ACADEMIES PRESS This PDF is available at http://nap.edu/1097 SHARE Mapping and Sequencing the Human Genome (1988) DETAILS 128 pages | | PAPERBACK ISBN 978-0-309-03840-9 | DOI 10.17226/1097 CONTRIBUTORS GET THIS BOOK Committee on Mapping and Sequencing the Human Genome, National Research Council FIND RELATED TITLES SUGGESTED CITATION National Research Council 1988. Mapping and Sequencing the Human Genome. Washington, DC: The National Academies Press. https://doi.org/10.17226/1097. Visit the National Academies Press at NAP.edu and login or register to get: – Access to free PDF downloads of thousands of scientific reports – 10% off the price of print titles – Email or social media notifications of new titles related to your interests – Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. (Request Permission) Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Copyright © National Academy of Sciences. All rights reserved. Mapping and Sequencing the Human Genome i Mapping and Sequencing the Human Genome Committee on Mapping and Sequencing the Human Genome Board on Basic Biology Commission on Life Sciences National Research Council NATIONAL ACADEMY PRESS Washington, D.C. 1988 Copyright National Academy of Sciences. All rights reserved. Mapping and Sequencing the Human Genome ii NATIONAL ACADEMY PRESS 2101 CONSTITUTION AVENUE, NW WASHINGTON, DC 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sci- ences, the National Academy of Engineering, and the Institute of Medicine. The National Academy of Sciences is a private nonprofit, self-perpetuating society of distin- guished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the fed- eral government on scientific and technical matters. Dr. Frank Press is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sci- ences the resonsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Robert M. White is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy mat- ters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal govern- ment and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Samuel O. Thier is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of further- ing knowledge and of advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. It is administered jointly by both Academies and the Institute of Medicine. Dr. Frank Press and Dr. Robert M. White are chairman and vice chairman, respectively, of the National Research Council. This study by the Board on Basic Biology was funded by the James S. McDonnell Foundation of Saint Louis, Missouri. Library of Congress Catalog Card Number 88-60584 International Standard Book Number 0-309-03840-5 Copyright © 1988 by the National Academy of Sciences No part of this book may be reporoduced by any mechanical, photographic, or electronic process, or in the form of a phonographic recording, nor may it be stored in a retrieval system, transmitted, or otherwise copied for public or private use, without written permission from the publisher, except for the purposes of official use by the United States Government. Printed in the United States of America. First Printing, April 1988 Second Printing, January 1989 Third Printing, June 1990 Fourth Printing, February 1991 Copyright National Academy of Sciences. All rights reserved. Mapping and Sequencing the Human Genome iii Committee on Mapping and Sequencing the Human Genome BRUCE M. ALBERTS (Chairman), University of California, San Francisco, California DAVID BOTSTEIN, Massachusetts Institute of Technology, Cambridge, Massachusetts SYDNEY BRENNER, MRC Unit of Molecular Genetics, Cambridge, United Kingdom CHARLES R. CANTOR, Columbia University College of Physicians and Surgeons, New York, New York RUSSELL F. DOOLITTLE, University of California, San Diego, California LEROY HOOD, California Institute of Technology, Pasadena, California VICTOR A. McKUSICK, Johns Hopkins Hospital, Baltimore, Maryland DANIEL NATHANS, The Johns Hopkins University School of Medicine, Baltimore, Maryland MAYNARD V. OLSON, Washington University School of Medicine, St. Louis, Missouri STUART ORKIN, Harvard Medical School, Boston, Massachusetts LEON E. ROSENBERG, Yale University School of Medicine, New Haven, Connecticut FRANCIS H. RUDDLE, Yale University, New Haven, Connecticut SHIRLEY TILGHMAN, Princeton University, Princeton, New Jersey JOHN TOOZE, European Molecular Biology Organization, Heidelberg, Federal Republic of Germany JAMES D. WATSON, Cold Spring Harbor Laboratory, Long Island, New York Advisers to the Committee ALBERT R. JONSEN, University of California, San Francisco, California ERIC JUENGST, University of California, San Francisco, California National Research Council Staff JOHN E. BURRIS, Study Director ROBERT A. MATHEWS, Staff Officer (through August 7, 1987) CAITILIN GORDON, Editor FRANCES WALTON, Administrative Secretary Copyright National Academy of Sciences. All rights reserved. Mapping and Sequencing the Human Genome iv Board on Basic Biology FRANCISCO J. AYALA (Chairman), University of California, Irvine NINA V. FEDOROFF, Carnegie Institution of Washington, Baltimore, Maryland TIMOTHY H. GOLDSMITH, Yale University, New Haven, Connecticut RALPH W. F. HARDY, Cornell University, Ithaca, New York ERNEST G. JAWORSKI, Monsanto Company, St. Louis, Missouri SIMON A. LEVIN, Cornell University, Ithaca, New York HAROLD A. MOONEY, Stanford University, Stanford, California HAROLD J. MOROWITZ, Yale University, New Haven, Connecticut WILLIAM E. PAUL, National Institutes of Health, Bethesda, Maryland DAVID D. SABATINI, New York University, New York, New York MALCOLM S. STEINBERG, Princeton University, Princeton, New Jersey JOSEPH E. VARNER, Washington University, St. Louis, Missouri DAVID B. WAKE, University of California, Berkeley JOHN E. DOWLING (ex-officio), Harvard University, Cambridge, Massachusetts JOHN E. BURRIS, Director Copyright National Academy of Sciences. All rights reserved. Mapping and Sequencing the Human Genome v Commission on Life Sciences JOHN E. DOWLING (Chairman), Harvard University, Cambridge, Massachusetts PERRY L. ADKISSON, The Texas A&M University System, College Station FRANCISCO J. AYALA, University of California, Irvine J. MICHAEL BISHOP, The G. W. Hooper Research Foundation, San Francisco, California NINA V. FEDOROFF, Carnegie Institution of Washington, Baltimore, Maryland TIMOTHY H. GOLDSMITH, Yale University, New Haven, Connecticut RICHARD W. HANSON, Case Western Reserve University School of Medicine, Cleveland, Ohio RALPH W. F. HARDY, Cornell University, Ithaca, New York RICHARD J. HAVEL, University of California, San Francisco School of Medicine DONALD F. HORNIG, Harvard School of Public Health, Boston, Massachusetts ERNEST G. JAWORSKI, Monsanto Company, St. Louis, Missouri SIMON A. LEVIN, Cornell University, Ithaca, New York FRANKLIN M. LOEW, School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts ROBERT W. MANN, Massachusetts Institute of Technology, Cambridge, Massachusetts HAROLD A. MOONEY, Stanford University, Stanford, California JOSEPH E. RALL, National Institutes of Health, Bethesda, Maryland RICHARD D. REMINGTON, University of Iowa, Iowa City RICHARD B. SETLOW, Brookhaven National Laboratory, Upton, New York JOSEPH E. VARNER, Washington University, St. Louis, Missouri ALVIN G. LAZEN, Executive Director Copyright National Academy of Sciences. All rights reserved. Mapping and Sequencing