10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 NOD2 Antibody (Center) Blocking peptide Synthetic peptide Catalog # BP11780c Specification NOD2 Antibody (Center) Blocking peptide NOD2 Antibody (Center) Blocking peptide - - Background Product Information The protein encoded by this gene is a member Primary Accession Q9HC29 of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus NOD2 Antibody (Center) Blocking peptide - Additional Information of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression Gene ID 64127 anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on Other Names chromosome 1q21. This protein may functionin Nucleotide-binding oligomerization motility, invasion, and tubulin polymerization. domain-containing protein 2, Caspase Chromosomalrearrangements and altered recruitment domain-containing protein 15, expression of this gene have beenimplicated in Inflammatory bowel disease protein 1, NOD2, CARD15, IBD1 tumor metastasis. Multiple alternatively splicedvariants, encoding the same protein, Format have been identified. Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in NOD2 Antibody (Center) Blocking peptide solution using the appropriate buffer as - References needed. Ma, X., et al. Cancer Lett. Storage 299(2):171-181(2010)Miranda, K.J., et al. J. Maintain refrigerated at 2-8°C for up to 6 Biol. Chem. 285(41):31517-31524(2010)van months. For long term storage store at Dieck, J., et al. FEBS Lett. -20°C. 584(15):3269-3274(2010)Cunningham, M.F., et al. Am. J. Physiol. Gastrointest. Liver Physiol. Precautions 299 (2), G457-G466 (2010) :Mencia, N., et al. This product is for research use only. Not BMC Cancer 10, 250 (2010) : for use in diagnostic or therapeutic procedures. NOD2 Antibody (Center) Blocking peptide - Protein Information Name NOD2 Synonyms CARD15, IBD1 Function Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as Page 1/2 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:<a h ref="http://www.uniprot.org/citations/18511 561" target="_blank">18511561</a>). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:<a href="http://www.uni prot.org/citations/20637199" target="_blank">20637199</a>). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:<a href="http://w ww.uniprot.org/citations/19701189" target="_blank">19701189</a>). Cellular Location Cytoplasm. Membrane. Mitochondrion. Basolateral cell membrane Tissue Location Expressed in intestinal mucosa, mainly in Paneth cells and, at lower extent, in the glandular epithelium NOD2 Antibody (Center) Blocking peptide - Protocols Provided below are standard protocols that you may find useful for product applications. • Blocking Peptides Page 2/2 Powered by TCPDF (www.tcpdf.org).