Global Reference List of Chemically Defined Substances 24/08/2021 Visit www.iofi.org for the latest version of the IOFI Global Reference List! 1 Table of contents: Global Reference List of Chemically Defined Substances - p. 3 Global Reference List of Chemically Defined Substances - List of materials with an INS number - p. 74 Glossary - p. 75 Visit www.iofi.org for the latest version of the IOFI Global Reference List! 2 Global Reference List of Chemically Defined Substances 24/08/2021 Name CAS JECFA JECFA - Safety Status FEMA FEMA - Safety Status FL. No EFSA - Safety Status (Link to WHO Database) (Link to FEMA Flavor Library) (Link to EFSA Database) Allyl propionate 2408-20-0 0001 Evaluated - No safety concern 2040 GRAS List 3 09.233 No need for evaluation (Genotoxicity cleared) Allyl butyrate 2051-78-7 0002 Evaluated - No safety concern 2021 GRAS List 3 (25) 09.054 No need for evaluation (Genotoxicity cleared) Allyl hexanoate 123-68-2 0003 Evaluated - No safety concern 2032 GRAS List 3 09.244 No need for evaluation (Genotoxicity cleared) Allyl heptanoate 142-19-8 0004 Evaluated - No safety concern 2031 GRAS List 3 09.097 No need for evaluation (Genotoxicity cleared) Allyl octanoate 4230-97-1 0005 Evaluated - No safety concern 2037 GRAS List 3 09.119 No need for evaluation (Genotoxicity cleared) Allyl nonanoate 7493-72-3 0006 Evaluated - No safety concern 2036 GRAS List 3 09.109 No need for evaluation (Genotoxicity cleared) Allyl isovalerate 2835-39-4 0007 Evaluated - No safety concern 2045 GRAS List 3 (25) 09.489 No need for evaluation (Genotoxicity cleared) Allyl sorbate 7493-75-6; 0008 Evaluated - No safety concern 2041 GRAS List 3 09.312 No need for evaluation 30895-79-5 (Genotoxicity cleared) Allyl 10-undecenoate 7493-76-7 0009 Evaluated - No safety concern 2044 GRAS List 3 09.146 No need for evaluation (Genotoxicity cleared) Allyl tiglate 7493-71-2 0010 Evaluated - No safety concern 2043 GRAS List 3 09.493 No need for evaluation (Genotoxicity cleared) Allyl 2-ethylbutyrate 7493-69-8 0011 Evaluated - No safety concern 2029 GRAS List 3 09.410 No need for evaluation (Genotoxicity cleared) Allyl cyclohexane acetate 4728-82-9 0012 Evaluated - No safety concern 2023 GRAS List 3 09.482 No need for evaluation (Genotoxicity cleared) Allyl cyclohexane propionate 2705-87-5 0013 Evaluated - No safety concern 2026 GRAS List 3 09.498 No need for evaluation (Genotoxicity cleared) Allyl cyclohexane butyrate 7493-65-4 0014 Evaluated - No safety concern 2024 GRAS List 3 09.411 No need for evaluation (Genotoxicity cleared) Allyl cyclohexanevalerate 7493-68-7 0015 Evaluated - No safety concern 2027 GRAS List 3 09.469 No need for evaluation (Genotoxicity cleared) Allyl cyclohexane hexanoate 7493-66-5 0016 Evaluated - No safety concern 2025 GRAS List 3 (25) 09.492 No need for evaluation (Genotoxicity cleared) Allyl phenylacetate 1797-74-6 0017 Evaluated - No safety concern 2039 GRAS List 3 09.790 No need for evaluation (Genotoxicity cleared) Allyl phenoxyacetate 7493-74-5 0018 Evaluated - No safety concern 2038 GRAS List 3 (25) 09.701 No need for evaluation (Genotoxicity cleared) Allyl cinnamate 1866-31-5 0019 Evaluated - No safety concern 2022 GRAS List 3 09.741 No need for evaluation (Genotoxicity cleared) Allyl anthranilate 7493-63-2 0020 Evaluated - No safety concern 2020 GRAS List 3 09.719 No need for evaluation (Genotoxicity cleared) Allyl 2-furoate 4208-49-5 0021 Evaluated - No safety concern 2030 GRAS List 3 13.004 No longer supported for evaluation Benzaldehyde 100-52-7 0022 Evaluated - No safety concern 2127 GRAS List 3 05.013 Evaluated - No safety concern Benzyl acetate 140-11-4 0023 Evaluated - No safety concern 2135 GRAS List 3 09.014 Evaluated - No safety concern Benzyl benzoate 120-51-4 0024 Evaluated - No safety concern 2138 GRAS List 3 09.727 Evaluated - No safety concern Benzyl alcohol 100-51-6 0025 Evaluated - No safety concern 2137 GRAS List 3 02.010 Evaluated - No safety concern Ethyl formate 109-94-4 0026 Evaluated - No safety concern 2434 GRAS List 3 09.072 No need for evaluation Ethyl acetate 141-78-6 0027 Evaluated - No safety concern 2414 GRAS List 3 09.001 No need for evaluation Ethyl propionate 105-37-3 0028 Evaluated - No safety concern 2456 GRAS List 3 09.121 No need for evaluation Ethyl butyrate 105-54-4 0029 Evaluated - No safety concern 2427 GRAS List 3 09.039 No need for evaluation Visit www.iofi.org for the latest version of the IOFI Global Reference List! 3 Global Reference List of Chemically Defined Substances 24/08/2021 Name CAS JECFA JECFA - Safety Status FEMA FEMA - Safety Status FL. No EFSA - Safety Status (Link to WHO Database) (Link to FEMA Flavor Library) (Link to EFSA Database) Ethyl pentanoate 539-82-2 0030 Evaluated - No safety concern 2462 GRAS List 3 09.147 No need for evaluation Ethyl hexanoate 123-66-0 0031 Evaluated - No safety concern 2439 GRAS List 3 09.060 No need for evaluation Ethyl heptanoate 106-30-9 0032 Evaluated - No safety concern 2437 GRAS List 3 09.093 No need for evaluation Ethyl octanoate 106-32-1 0033 Evaluated - No safety concern 2449 GRAS List 3 (25) 09.111 No need for evaluation Ethyl nonanoate 123-29-5 0034 Evaluated - No safety concern 2447 GRAS List 3 09.107 No need for evaluation Ethyl decanoate 110-38-3 0035 Evaluated - No safety concern 2432 GRAS List 3 (25) 09.059 No need for evaluation Ethyl undecanoate 627-90-7 0036 Evaluated - No safety concern 3492 GRAS List 10 09.274 No need for evaluation Ethyl dodecanoate 106-33-2 0037 Evaluated - No safety concern 2441 GRAS List 3 09.099 No need for evaluation Ethyl tetradecanoate 124-06-1 0038 Evaluated - No safety concern 2445 GRAS List 3 09.104 No need for evaluation Ethyl hexadecanoate 628-97-7 0039 Evaluated - No safety concern 2451 GRAS List 3 (25) 09.193 No need for evaluation Ethyl octadecanoate 111-61-5 0040 Evaluated - No safety concern 3490 GRAS List 10 09.210 No need for evaluation Ethanol 64-17-5 0041 Evaluated - No safety concern 2419 GRAS List 3 02.078 No need for evaluation Isoamyl formate 110-45-2 0042 Evaluated - No safety concern 2069 GRAS List 3 09.162 No need for evaluation Pentyl acetate 628-63-7 0043 Evaluated - No safety concern 2055 GRAS List 3 09.021 No need for evaluation Isoamyl acetate 123-92-2 0043 Evaluated - No safety concern 2055 GRAS List 3 09.024 No need for evaluation Isoamyl propionate 105-68-0 0044 Evaluated - No safety concern 2082 GRAS List 3 09.136 No need for evaluation Isoamyl butyrate 106-27-4 0045 Evaluated - No safety concern 2060 GRAS List 3 09.055 No need for evaluation Isoamyl hexanoate 2198-61-0 0046 Evaluated - No safety concern 2075 GRAS List 3 09.070 No need for evaluation Isoamyl octanoate 2035-99-6 0047 Evaluated - No safety concern 2080 GRAS List 3 (25) 09.120 No need for evaluation Isoamyl nonanoate 7779-70-6 0048 Evaluated - No safety concern 2078 GRAS List 3 09.110 No need for evaluation Isoamyl isobutyrate 2050-01-3 0049 Evaluated - No safety concern 3507 GRAS List 10 09.419 No need for evaluation Isoamyl isovalerate 659-70-1 0050 Evaluated - No safety concern 2085 GRAS List 3 09.463 No need for evaluation Isoamyl 2-methylbutyrate 27625-35-0 0051 Evaluated - No safety concern 3505 GRAS List 10 09.530 No need for evaluation Isoamyl alcohol 123-51-3 0052 Evaluated - No safety concern 2057 GRAS List 3 02.003 No need for evaluation Citronellyl formate 105-85-1 0053 Evaluated - No safety concern 2314 GRAS List 3 (25) 09.078 No need for evaluation Geranyl formate 105-86-2 0054 Evaluated - No safety concern 2514 GRAS List 3 09.076 Evaluated - No safety concern Neryl formate 2142-94-1 0055 Evaluated - No safety concern 2776 GRAS List 3 (25) 09.212 Evaluated - No safety concern Rhodinyl formate 141-09-3 0056 Evaluated - No safety concern 2984 GRAS List 3 (25) 09.079 No need for evaluation Citronellyl acetate 150-84-5 0057 Evaluated - No safety concern 2311 GRAS List 3 09.012 No need for evaluation Geranyl acetate 105-87-3 0058 Evaluated - No safety concern 2509 GRAS List 3 09.011 Evaluated - No safety concern Neryl acetate 141-12-8 0059 Evaluated - No safety concern 2773 GRAS List 3 (25) 09.213 Evaluated - No safety concern Rhodinyl acetate 141-11-7 0060 Evaluated - No safety concern 2981 GRAS List 3 09.033 No need for evaluation Citronellyl propionate 141-14-0 0061 Evaluated - No safety concern 2316 GRAS List 3 (25) 09.129 No need for evaluation Geranyl propionate 105-90-8 0062 Evaluated - No safety concern 2517 GRAS List 3 09.128 Evaluated - No safety concern Neryl propionate 105-91-9 0063 Evaluated - No safety concern 2777 GRAS List 3 09.169 Evaluated - No safety concern Rhodinyl propionate 105-89-5 0064 Evaluated - No safety concern 2986 GRAS List 3 09.141 No need for evaluation Citronellyl butyrate 141-16-2 0065 Evaluated - No safety concern 2312 GRAS List 3 09.049 No need for evaluation Geranyl butyrate 106-29-6 0066 Evaluated - No safety concern 2512 GRAS List 3 09.048 Evaluated - No safety concern Neryl butyrate 999-40-6 0067 Evaluated - No safety concern 2774 GRAS List 3 (25) 09.167 Evaluated - No safety concern Rhodinyl butyrate 141-15-1 0068 Evaluated - No safety concern 2982 GRAS List 3 09.927 No need for evaluation Citronellyl valerate 7540-53-6 0069 Evaluated - No safety concern 2317 GRAS List 3 09.151 No need for evaluation Geranyl hexanoate 10032-02-7 0070 Evaluated - No safety concern 2515 GRAS List 3 (25) 09.067 Evaluated - No safety concern Citronellyl isobutyrate 97-89-2 0071 Evaluated - No safety concern 2313 GRAS List 3 (25) 09.421 No need for evaluation Geranyl isobutyrate 2345-26-8 0072 Evaluated - No safety concern 2513 GRAS List 3 (25) 09.431