1 CLASSIFICATION OF ANTIMICROBIAL AGENTS DR ARPITA SHRIVASTAV,ASSISTANT PROFESSOR DEPARTMENT OF PHARMACOLOGY & TOXICOLOGY COLLEGE OF VETERINARY SCIENCE & A.H. REWA Classification of 2 antimicrobial agents 1.Based on mechanism of action 2.Based on therapeutic use/ organisms affected 3.Based on spectrum of activity 4.Based on type of action 5.Antimycobacterial agents 6.Based on source 7.Based on Chemical structure 1.Based on mechanism of 3 action A. Cell wall synthesis inhibitor a. Penicillin b. Cephalosporins c. Cycloserine d. Bacitracin e. Vancomycin f. Clotrimazole g. Monobactum Cell membrane synthesis 4 inhibitor a. Amphoterecin B b. Polymyxin c. Nystatin d. Meconazole Protein synthesis inhibitor 5 a. Binding with 50s RNA unit- eg.Chloramphenicol,Tetracyclines, Clindamycin, Macrolides b. Binding with 30s RNA unit-eg. Tetracyclines, Aminoglycosides, Spectinomycin c. Inhibiting elongation factor-eg. Fusidic acid Nucleic acid synthesis 6 inhibitor a. RNA synthesis inhibitor-eg.Rifamycin ,Rifampicin b. DNA synthesis inhibitor-eg.Quinolones Interfere with intermediary metabolism a. sulfonamide b. Trimethoprim c. Pyrimethamine 2.Based on therapeutic 7 use/ organisms affected Antibacterial Antifungal a. Penicillin,, a. AmphotericinB, b. Chloramphenicol b. Griseofulvin c. tetracyclines c. kotoconazole d. Aminoglycosides 8 Antiviral Antiprotozoal a. Acyclovir a. Metronidazole b. Idoxuridine b. Quinapyramine c. Vidarabine c. Diminazine d. Zidovudine e. Ribavirin 9 Anthelmintics Ectoparasiticides a. Albendazole a. Cypermethrin b. Levamisole b. Lindane c. Niclosamide c. Amitraz d. praziquantel d. Ethion 3.Based on spectrum of 10 activity Narrow spectrum- Broad spectrum a. Tetracyclines a. penicillin G b. Chloramphenicol b. Streptomycin c. Gentamycin c. Erythromycin d. Ampicillin d. Vencomycin 4.Based on type of action 11 Bacteriostatics Bactericidal a. Erythromycin a. Penicillin G b. Sulfonamide b. Streptomycin c. Trimethoprim c. Vencomycin d. Clindamycin d. Bacitracin e. Chloramphenicol e. Potentiated sulfonamides f. Cephalexin 5.Antimycobacterial agents 12 a. Isoneazide b. Paraamino salisyclic acid. 6.Based on source 13 Funji Actinomycetes- a. Penicillin G a. Erythromycin b. Cephalexin b. Chloramphenicol c. Griseofulvin c. Streptomycin d. Tetracyclines 14 Bacteria Synthetic a. PolymyxinB a. Sulfonamide b. Colistin, b. Trimethoprim c. Bacitracin c. Quinolones d. Nitrofurans e. Nitroimidazole 7.Based on Chemical 15 structure a. Sulfonamide group-trimethoprim,ormethoprim baquiloprim b. Diaminopyramidine group- Sulphadimidine,sulphadiazine,sulphanilamide c . Quinolones-nalidixic acid, enrofloxin, ciprofloxin d. Beta lactam antibiotics-Penicillin G,Ampicillin cephalexin Cloxacillin e. Aminoglycosides –Streptomycin gentamycin f. Tetracycline- Tetracycline,Doxycyclines,oxytetracyclines 16 g. Macrolides-Eryomycin, azithromycin h. Polypeptide antibiotics --Polymyxin B, Colistin,Bacitracin i. Nitrofuran derivatives-Nitrofurantoin,furazolidone j. Nitroimidazoles-Metronidazole, tinidazole k. Polyene antibiotics- AmphotericinB,Nystatin l. Imidazole derivatives-Ketoconazole fluconazole, clotrimazole. 17.