2012 ANNUAL REPORT CIHR STAGE Program Advisory Committee Meeting January 24 & 25, 2013 Toronto, Ontario PROGRESS REPORT RECRUITMENT AND BUDGET Page Page 01 01 Co-Directors Message 1 STAGE Competitions: Applicant-Publication 20 02 Records-Comparison Co-principal Investigators, Co-investigators, 3 02 and Collaborators Projected and Actual Admissions 22 03 03 Summary of Changes 5 Current Trainees 23 04 04 Progress 8 Alumni 25 05 05 List of Acronyms 17 Trainee Productivity 26 06 06 Governance Structure 18 Trainee Awards, Distinctions, and Honours 27 07 Budget 29 CURRICULUM APPENDICES Page A Summary of Grant Proposal 01 Components, Training Objectives, and 30 B List of Trainee Publications Assessable Outcomes C Representative Trainee Publications 02 Integrative and Cross-disciplinary Courses 32 D List of Mentors 03 International Speaker Seminar Series 34 E Mentors-Mentee Agreement F Syllabi-Integrative Courses G Steering Committee Meeting Minutes, Oct. 2012 H STAGE International Internship and Travel Award Programs I Syllabi and Agendas for Professional Development Courses and Workshops J Trainee Annual Progress Report and Exit Survey K GAW18 Workshop - Resulting Papers and Participating STAGE Mentors and Trainees L Mentoring Commitment Message STAGE - PAC 2012 Annual Report Page 5 01 CO-DIRECTORS MESSAGE Drs. SHELLEY B. BULL & FRANCE GAGNON Dear members of the Program Advisory Committee: Thank you very much for your wise counsel and valuable guidance regarding the progress of STAGE and its future directions. Your critical evaluation of how STAGE fulfils its mission and objectives, and how it can improve is essential. The program’s midterm review by the Canadian Institutes for Health Research (CIHR) (Strategic Training Initiative in Health Research (STIHR) Program) on November 2013 will determine funding for the last three years of operation, until 2016. This document updates and incorporates the text of the Annual Progress Report submitted to CIHR on November 1, 2012, and adds program statistics useful to the Program Advisory Committee (PAC). The text component (pages 3-15) approximates what is expected to be submitted to CIHR for its midterm review in late 2013. CIHR is expected to evaluate how well STAGE has met its own mission and objectives and those of STIHR, listed in page 8. Most importantly, we would like to know if STAGE is on the right course to achieve its Vision to become a destination for training in genetic epidemiology and statistical genetics for Canadian and international trainees. We ask that you carefully consider the information in this report in your assessment of the performance of STAGE, and that you prepare comments and recommendations for the January 24 & 25, 2013 PAC Meeting, including: • how accurately the information provided reflects STAGE’s accomplishments, • how STAGE reporting materials might be improved or modified to better reflect program successes, progress, and challenges, • how well STAGE is fulfilling each STIHR and STAGE objective, • your suggested specific program improvements in the context of each STIHR and STAGE objectives, • your assessment of how STAGE compares to other training programs in genetic epidemiology and statistical genetics, internationally, and • any other relevant or useful guidance regarding STAGE that you would like to provide. Shelley B. Bull, PhD. France Gagnon, MSc., PhD. Co-Director, CIHR STAGE Co-Director, CIHR STAGE Senior Investigator, Canada Research Chair in Genetic Epidemiology Samuel Lunenfeld Research Institute of Associate Professor, Division of Epidemiology Mount Sinai Hospital Dalla Lana School of Public Health Professor, Division of Biostatistics, Dalla University of Toronto Lana School of Public Health University of Toronto STAGE - PAC 2012 Annual Report Page 1 STAGE - PAC 2012 Annual Report Page 2 02 CO-PRINCIPAL INVESTIGATORS, CO-INVESTIGATORS, AND COLLABORATORS STIHR REPORT INSTRUCTION STAGE RESPONSE List all co-principal investigators, The current complement of 43 STAGE mentors encompasses co-investigators, primary mentors and three discipline-based mentor pools (11 mentors in Genetic collaborators (including international and Molecular Epidemiology, 14 in Statistical Genetics and collaborators) along with their university Genomics, and 18 in Bio-Medical Genetics). To date, 20 affiliations and a description of their roles (47%) mentors have supervised STAGE trainees, 9 (21%) and activities. Describe briefly significant as primary mentors and 18 (42%) as co-mentors, see Table changes, if any, which have occurred during 1, below), 17 (40%) contribute to teaching courses on the the reporting period. Include changes to STAGE curriculum, and most mentors participate actively the program’s team (co-investigators no in the program through attendance at the ISSS, research longer participating, collaborations that collaborations with STAGE trainee teams, and serve on the are no longer in place, etc.), and list new Admissions and/or Steering Committee. Appendix D lists all co-investigators and collaborations. STAGE mentors and their involvement in the program, and Table 2, in page 4, lists new major mentor distinctions. TABLE 1. TRAINEE-MENTOR TEAMS Mentors by # of Primary Co- Graduate (Master’s & PhDs) Postdoctoral Fellows Visiting Scholar Research Area* Trainees mentor mentor *Genetic & Molecular Epidemiology Kung, Dennis, Ladouceur, Gagnon, France 3 3 1 Tabitha Jessica Martin • Brenner, Fehringer, Hung, Rayjean 3 2 1 Darren • Gord Woodbury- Paterson, Andrew 6 1 5 ••• •• Smith, Marc Knight, Julia 2 2 •• *Statistical Genetics & Genomics Wu, Yan Briollais, Laurent 2 1 1 • Yan Faye, Chen, Yilmaz, Bull, Shelley 4 3 1 • Laura Zhijian Yildiz Craiu, Radu 1 1 • Lemire, Mathieu 1 1 • Weili, Miller, Strug, Lisa 4 2 2 • Li Melissa • Derkach, Sun, Lei 4 1 3 Andriy • • • *Biomedical Genetics Andrulis, Irene 1 1 • Jiang, Danska, Jayne 1 1 Yue Oliveira, Kennedy, James 1 1 Vanessa Liu, Geoffrey 2 2 • • Lye, Stephen 1 1 1 • Pausova, Zdenka 1 1 • Petronis, Arturas 1 1 • Rommens, Johanna 3 3 •• • Scherer, Steve 1 1 • Siminovitch, Katherine 2 1 1 • Primary mentors and mentees in same row, • = Co-mentor 1 Biomedical mentor invited to accommodate trainee-specific research interests unavailable from initial mentor-pool. 2 Ad hoc biomedical mentor invited to accommodate trainee-specific research interests unavailable from initial mentor-pool. STAGE - PAC 2012 Annual Report Page 3 02 CO-PRINCIPAL INVESTIGATORS, CO-INVESTIGATORS, AND COLLABORATORS (continued) Mentors: New Distinctions and Leadership Roles TABLE 2. NEW DISTINCTIONS AND LEADERSHIP ROLES Name Organization Award Name/Distinction In recognition of Steven Narod Royal Society of Canada Elected Fellow. Steven Narod has proven that hereditary breast/ovarian cancers are preventable, and he has also found that Through their exceptional work, these many Ontario women with BRCA1/2 mutations are new Fellows pursue the distinguished work ineligible for provincially funded genetic testing. For of a long line of researchers and creators women unwilling to undergo radical surgeries, he is who have contributed to expand Canada’s pinpointing dietary options that reduce risk. His database intellectual, artistic and scientific resources of 12,000+ women from 30 countries supports numerous to support Canada’s population and its international collaborations. Author of over 550 peer- international scope. reviewed publications, Dr. Narod has an H-index of 84. James Kennedy Royal Society of Canada Elected Fellow. James Kennedy’s innovative research has resulted in pioneering discoveries relating gene variants to psychiatric Through their exceptional work, these disorders, brain imaging and treatment response. He new Fellows pursue the distinguished work has found genetic predictors of risk for attention deficit of a long line of researchers and creators disorder, schizophrenia, obsessive compulsive disorder, who have contributed to expand Canada’s mood disorders, and medication side effects including intellectual, artistic and scientific resources tardive dyskinesia, drug-induced mania and weight gain. He to support Canada’s population and its has translated these findings into pharmacogenetic tests in international scope. clinical care, and influenced pharmacogenetic research and its application at an international level. Shelley B. Bull International Genetic Epidemiology Leadership Award Shelley B. Bull’s contributions and for being instrumental in Society shaping the International Genetic Epidemiology Society France Gagnon Human Genetics Guest editor for the Human Genetics special N.A. issue on Genetic Epidemiology: Study Designs and Methods post-GWAS. Lei Sun International Genetic Epidemiology Selected as a member of the Editorial Board N.A. Society for Genetic Epidemiology, the official journal of the International Genetic Epidemiology Society. STAGE - PAC 2012 Annual Report Page 4 03 SUMMARY OF CHANGES STIHR REPORT INSTRUCTION Steering Committee in Dec. 2011 (see Appendix L). This process aligns trainee-research interests, Describe any changes in design, direction, as they become known, with mentoring pool objectives, team makeup, collaborations or expertise. Mentor responses are yet to be tallied. milestones, focusing on the reporting period of September 1, 2011 to August 31, 2012. Attach, as STAGE is refining procedures and criteria for inviting Appendix A, a copy of the Summary of Research new mentors, taking into account and addressing Proposal from the original application. gaps in expertise of the initial mentor pool. At