Introduction to Bioelectricity Week 4: The Hodgkin-Huxley model Lecture 4.1: Alan Hodgkin and Andrew Huxley By Pedro P. Irazoqui Associate Professor of Biomedical Engineering and Electrical and Computer Engineering Purdue University 1 Week 4: The Hodgkin-Huxley model • Lecture 4.1: A. Hodgkin and A. Huxley Alan Lloyd Hodgkin Andrew Huxley Wikimedia Commons freely licensed media 2 Lecture 4.1: A. Hodgkin and A. Huxley • British Empire 1919 Wikimedia Commons freely licensed media 3 Lecture 4.1: A. Hodgkin and A. Huxley • World War 1 Wikimedia Commons freely licensed media 4 Lecture 4.1: A. Hodgkin and A. Huxley • Casualties: • 995,939 war dead (out of 9,722,620) • Roughly 10% of male population aged 20-40 • 1,663,435 severely wounded • Roughly 20% of male population aged 20-40 • Orthopedics: • Otto Bock Wikimedia Commons freely licensed media 5 Lecture 4.1: A. Hodgkin and A. Huxley • Spanish Flu (H1N1) • Worldwide: ~40,000,000 • UK: ~250,000 • Disproportionately 20-40 year olds Wikimedia Commons freely licensed media 6 Lecture 4.1: A. Hodgkin and A. Huxley • Allan Lloyd Hodgkin • 1914-1998 • Oxfordshire • WW II • Cambridge Wikimedia Commons freely licensed media 7 Lecture 4.1: A. Hodgkin and A. Huxley • Andrew Fielding Huxley • 1917-2012 • London • WW II • Cambridge Wikimedia Commons freely licensed media 8 Lecture 4.1: A. Hodgkin and A. Huxley • Andrew Fielding Huxley • 1917-2012 • London • WW II • Cambridge • Brother: Aldous Huxley • Grandson: Thomas Huxley Wikimedia Commons freely licensed media 9 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 10 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 11 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 12 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 13 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 14 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 15 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 16 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 17 Lecture 4.1: A. Hodgkin and A. Huxley • Trinity College, Cambridge • 31 of 89 Nobel prizes • 5 of 6 Fields medals • Alumns & Fellows: • Isaac Newton • James Maxwell • Francis Bacon • Francis Galton • Niels Bohr • Bertrand Russell • Ludwig Wittgenstein • Kim Philby, Guy Burgess, and Anthony Blunt Wikimedia Commons freely licensed media 18 Lecture 4.1: A. Hodgkin and A. Huxley • The Hodgkin & Huxley partnership • 1935-1939 • The Voltage Clamp • 1946-1952 • The Hodgkin-Huxley Model • 1952-1957 • Sliding filament theory of muscle contraction • 1963 • Nobel prize in physiology or medicine • 1978-1984 & 1984-1990 • Masters of Trinity 19 .