1. X-R, O N 1999;63:1-38

1. X-R, O N 1999;63:1-38

USOO6423719B1 (12) United States Patent (10) Patent No.: US 6,423,719 B1 Lawyer (45) Date of Patent: Jul. 23, 2002 (54) METHOD FOR TREATING BENIGN Hasan et al., “Antagonism of coronary artery relaxation by PROSTATE HYPERPLASA adenosine AA-receptor antagonist ZM241385,” J Cardio vasc Pharmacol. 2000 Feb.; 35(2):322–5. (75) Inventor: Carl H. Lawyer, Mequon, WI (US) Kotera et al., “Immunohistochemical localization of c(GMP binding c(GMP-specific phosphodiesterase (PDE5) in rat (73) Assignee: Upsher-Smith Laboratories, Inc., tissues,” J Histochem Cytochem. 2000 May;48(5):685–93. Minneapolis, MN (US) Landells et al., “The role of adenosine receptors in the action of theophylline on human peripheral blood mononuclear (*) Notice: Subject to any disclaimer, the term of this cells from healthy and asthmatic Subjects.” BrJ Pharmacol, patent is extended or adjusted under 35 2000 Mar.; 129(6):1140–4. U.S.C. 154(b) by 0 days. 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