7th Annual Conference September 24-27, 2018 ICBS 2018 Vancouver, Canada Scientific Program Towards Translational Impact www.chemical-biology.org 7th Annual Conference | September 24-27, 2018 | Vancouver, Canada Acknowledgements Towards Translational Impact September 24th – 27th, 2018 | Vancouver, BC Local Program and Organizing Committee Tom Pfeifer, Centre for Drug Research and Development Roger Linington, Simon Fraser University Michel Roberge, University of British Columbia Nicolette Honson, Centre for Drug Research and Development ICBS Organizing Committee Haian Fu, Chair, Emory University, USA Lixin Zhang, ECUST, China Sally-Ann Poulsen, Griffith University, Australia Jonathan Baell, Monash University, Australia Mahabir Gupta, University of Panama, Panama Junying Yuan, Harvard Medical School, USA Masatoshi Hagiwara, Kyoto University, Japan Petr Bartunek, CZ-OPENSCREEN and Institute of Molecular Jason Micklefield, The University of Manchester, UK Genetics, Czech Republic Siddhartha Roy, Bose Institute, India ICBS Young Chemical Biologist Award 2018 Selection Committee Yimon Aye, Cornell University, USA Christian Ottmann, Technische Universiteit Eindhoven, Ratmir Derda, University of Alberta, Canada Netherlands Evripidis Gavathiotis, Albert Einstein College of Medicine, USA William Pomerantz, University of Minnesota, USA Kenjiro Hanaoka, University of Tokyo, Japan Qi Zhang, Fudan University, China Recording of sessions (oral or poster) by audio, video, or still photography is strictly prohibited except with the advance permission of the author(s) and the conference organizers. Material contained in abstracts and presentations should be treated as personal communication and cited as such only with consent of the author(s). 2 www.chemical-biology.org ICBS 2018 Table of Contents Acknowledgements .....................................................2 Thank you to our conference sponsors ......................16 ICBS Board of Directors ..............................................4 Keynote Speakers .....................................................17 About ICBS .................................................................4 Presentations ............................................................19 ICBS International Advisory Board ...............................5 Rising Stars ...............................................................48 Program at a Glance ....................................................6 Exhibitors ..................................................................52 Welcome Letter ...........................................................9 Poster Presenters ......................................................53 Program ....................................................................10 Venue Map ................................................................55 Author Index A H M T Masahiko Ajiro ........................ 32 Fred Haeckl ............................ 53 Dawei Ma ............................... 39 Mirelle Takaki .......................... 54 Rima Al-awar .......................... 31 Stephen J. Haggarty ............... 36 Florian Mayerthaler ................. 34 Lily Takeuchi ........................... 54 Matthew Alteen ...................... 54 Ting Han................................. 19 Guillaume Médard .................. 54 Hong Yee Tan ......................... 53 Sebastian Andrei .................... 54 Evan Haney ............................ 54 James Meinig ......................... 53 Masayasu Toyomoto ............... 54 Albert A. Antolin ...................... 25 Kenjiro Hanaoka ..................... 54 Poncho Meisenheimer ............ 46 Michihiko Tsushima ................. 53 Heather Arnaiz ........................ 53 Jason Hedges ........................ 54 Jason Micklefield .................... 33 Doug Auld .............................. 54 Stephanie Heinzlmeir .............. 54 Cameron Murray ..................... 54 V Nicole Houszka ...................... 53 David Vocadlo ........................ 21 B N I Anne Bang ............................. 37 Seyed Nasseri ........................ 53 W Jeremy M. Baskin ................... 29 Takayuki Ikeno ........................ 53 Ali Nejatie ............................... 53 J.B. Brown ............................. 24 Alena Istrate ........................... 53 Sherry L Niessen .................... 42 Chu Wang .............................. 49 Andrey Ivanov ......................... 25 Shaomeng Wang .................... 19 Amy Weeks ............................ 54 C P Julian Wilke ............................ 53 J Robert Campbell .................... 45 Andrew J. Phillips ................... 43 Michael Winzker ..................... 53 Michelle Chang ...................... 33 Namrata Jain .......................... 40 Sally-Ann Poulsen ................... 27 Scott Wolkenberg ................... 30 Wansang Cho ......................... 53 Francois Jean ......................... 54 Polina Prokofeva ..................... 54 Jeffrey Y.K. Wong ................... 53 Michael Cohen ....................... 49 Shireen Jozi ............................ 54 Christina Woo ......................... 48 Q D K Y Kun Qian ................................ 54 Phillip Danby ........................... 54 Akane Kawamura ................... 54 Kenzo Yamatsugu .................. 53 Jennifer Kohler ...................... 21 R Milka Kostic ............................ 27 E Casey Krusemark ................... 31 Elena Reckzeh ........................ 53 Z Joseph Egan .......................... 53 Karson Kump ......................... 53 Anna Rutkowska-Klute ........... 54 Charlotte Zammit .................... 53 Syusuke Egoshi ...................... 53 Katherine Ryan ....................... 34 Cristina Zamora ...................... 22 L Andrew Zhang ........................ 42 F S Jin Zhang ............................... 45 Nicole LeGrow ........................ 53 Y. George Zheng .................... 43 Victor Fadipe .......................... 54 Jasmine Li-Brubacher ............. 53 Koichi Sasaki .......................... 54 Eric S. Fischer ........................ 20 Dennis Liu .............................. 53 Shinichi Sato .......................... 40 Frederic Friscourt .................... 22 Scott Lovell ............................ 28 Saiko Shibata ......................... 53 David Lupton .......................... 39 Eline Sijbesma ........................ 54 Ellen M. Sletten ....................... 46 G Kimberly Snyder ..................... 38 Thota Ganesh ......................... 54 Mathieu Soetens .................... 53 Thomas Garner ...................... 53 Barbara Sohr .......................... 53 Chloe Gerak ........................... 53 Paul Guyett ............................. 37 www.chemical-biology.org 3 7th Annual Conference | September 24-27, 2018 | Vancouver, Canada ICBS Board of Directors Lixin Zhang Haian Fu Jonathan Baell President (China) Chair of Board (USA) President Elect (Aus) Rathnam Chaguturu Tom Pfeifer Masatoshi Hagiwara Treasurer (USA) Secretary (Can) (Japan) Zaneta Nikolovska-Coleska Siddhartha Roy (USA) (India) About ICBS The International Chemical Biology Society (ICBS) is an independent, nonprofit organization dedicated to promoting research and educational opportunities at the interface of chemistry and biology. ICBS provides an important international forum that brings together cross-disciplinary scientists from academia, non profit organizations, government, and industry to communicate new research and help translate the power of chemical biology to advance human health. 4 www.chemical-biology.org ICBS 2018 ICBS International Advisory Board Stephen Benkovic Sir Philip Cohen Jian Ding Penn State University of Dundee Shanghai Institute of Materia Medica Chris Lipinski Ferid Murad Bernard Munos Melior Discovery George Washington University InnoThink Litao Zhang Stuart Schreiber Paul Workman Bristol-Myers Squibb Harvard ICR-London Tetsuo Nagano Leonard Zon Herbert Waldmann University of Tokyo HHM/Harvard Max Planck Institute of Molecular Physiology Junying Yuan Harvard www.chemical-biology.org 5 7th Annual Conference | September 24-27, 2018 | Vancouver, Canada Program at a Glance PRECONFERENCE: MONDAY, SEPTEMBER 24, 2018 8:00AM – 6:00PM Meeting Registration Playhouse Lobby 8:30AM – 9:00AM Coffee Playhouse Lobby 9:00AM – 5:00PM Young Chemical Biologists’ Forum Orchestra Right & Left 9:00AM – 9:10AM Welcome Orchestra Right & Left Expert-Led Forum 9:10AM – 9:40AM Chemistry for Biologists Jonathan Baell, Monash University, Australia Assay Development and Screening Doug Auld, Novartis Institute for 9:10AM – 11:10AM 9:40AM – 10:10AM Biomedical Research, USA 10:10AM – 10:40AM Structural Biology Scott Lovell, University of Kansas, USA 10:40AM – 11:10AM Insights for Chemical Biology in Industry Andrew Zhang, AstraZeneca, USA 11:10AM – 11:25AM Coffee Break Playhouse Lobby 11:25AM – 12:45PM Student-Led Forum, Presenters 1 through 5 Orchestra Right & Left 12:45 PM – 1:45PM Lunch on Your Own 1:45PM – 3:00PM Student-Led Forum, Presenters 6 through 10 Orchestra Right & Left Tech Talks Orchestra Right & Left Creating and Deploying Next Generation Informatics Solutions – What 3:00PM – 3:30PM 3:00PM – 3:15PM We’ve Learned Along the Way Whitney Smith, Collaborative Drug Discovery, USA 3:15PM – 3:30PM Antibody-Drug Conjugates Graham Garnett, Zymeworks, Canada 3:30PM – 3:50PM Coffee Break and Exhibitor Viewing Salon A 3:50PM – 4:00 PM ICBS Conference Welcome Orchestra Right & Left 4:00PM – 4:05PM Keynote Introduction