Buyers’ Guide S119 Buyers’ Guide Suppliers’ Contact Details Amersham Biosciences UK Limited The Menarini Group Amersham Place www.menarini.com Little Chalfont Buckinghamshire HP7 9NA Moravek Biochemicals UK 577 Mercury Lane www5.amershambiosciences.com Brea Ca 92821 Avanti Polar Lipids Inc USA 700 Industrial Park Drive www.moravek.com Alabaster AL 35007 Roche Pharmaceuticals USA F. Hoffmann-La Roche Ltd www.avantilipids.com Pharmaceuticals Division Grenzacherstrasse 124 Bachem Bioscience Inc. CH-4070 Basel 3700 Horizon Drive Switzerland King of Prussia Telephone þ 41-61-688 1111 PA 19406 Unites States Telefax þ 41-61-691 9391 www.bachem.org www.roche.com Boehringer Ingelheim Ltd Ellesfield Avenue SIGMA Chemicals/Sigma-Aldrich Bracknell P.O. Box 14508 Berks RG12 8YS St. Louis, MO 63178-9916 UK USA www.boehringer-ingelheim.co.uk www.sigma-aldrich.com Calbiochem Tocris Cookson Ltd. EMD Biosciences, Inc. Northpoint, Fourth Way 10394 Pacific Center Court Avonmouth San Diego Bristol CA 92121 BS11 8TA USA UK www.emdbiosciences.com www.tocris.com S120 Buyers’ Guide Compound Supplier Buyers’ Guide a-methyl-5-HT a-Methyl-5-hydroxytryptamine Tocris ab-meATP ab-methylene-adenosine 5’-triphosphate Sigma-Aldrich bg-meATP bg-methylene-adenosine 5’-triphosphate Sigma-Aldrich (-)-(S)-BAYK8664 (-)-(S)-methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluromethylphenyl)-pyridine-5-carboxylate Sigma-Aldrich, Tocris (+)7-OH-DPAT (+)-7-hydroxy-2-aminopropylaminotetralin Sigma-Aldrich a-dendrotoxin Sigma-Aldrich (RS)PPG (R,S)-4-phosphonophenylglycine Tocris (S)-3,4-DCPG (S)-3,4-dicarboxylphenylglycine Tocris [Ala1,3,11,15]ET-1 Sigma-Aldrich 12-(S)-HPETE 12-(S)-hydroperoxyeicosatetraenoic acid Sigma-Aldrich 1400W N-(3-(aminomethyl)benzyl)acetamidine Sigma-Aldrich, Tocris 15-(S)-HPETE 15-(S)-hydroperoxyeicosatetraenoic acid Sigma-Aldrich 15deoxy-PGJ2 Sigma-Aldrich 1S,3R-ACPD 1-aminocyclopentane-1S,3R-dicarboxylate Sigma-Aldrich, Tocris 2-APB 2-amino ethoxyphenylborate Tocris 2Cl-IB-MECA 2-chloro-N6-(3-iodobenzyl)adenosine-5’-N-methyluronamide Sigma-Aldrich, Tocris 2-MeSADP 2-methylthio-adenosine-5’-diphosphate Sigma-Aldrich 2-MeSATP 2-methylthio-adenosine-5’-triphosphate Sigma-Aldrich 2R,4R-APDC aminopyrrolidine-2R,4R-dicarboxylate also known as LY314593 Tocris 3-APMPA 3-amino-propyl-(P-methyl)-phosphinic acid, also known as CGP35024 3HPG 3-hydroxyphenylglycine Sigma-Aldrich, Tocris 4a-PDD 4a-phorbol 12,13-didecanoate Sigma-Aldrich 4-AP 4-aminopyridine Sigma-Aldrich 4CPG 4-carboxyphenylglycine Sigma-Aldrich, Tocris 4-DAMP 4-diphenylacetoxy-N-methylpiperidine methiodide Sigma-Aldrich, Tocris 4P-PDOT 4-phenyl-2-propionamidotetraline Tocris 5-(S)-HETE 5-(S)-hydroeicosatetraenoic acid Sigma-Aldrich 5-CT 5-carboxamidotryptamine Sigma-Aldrich, Tocris 5-fluoro-20-deoxyuridine Sigma-Aldrich 5-fluorouridine Sigma-Aldrich 5MCA-NAT 5-methoxy-carbonylamino-N-acetyltryptamine, also known as GR 135531 Sigma-Aldrich, Tocris 7NI 7-nitroindazole Sigma-Aldrich, Tocris 8-OH-DPAT 8-hydroxy-2-(di-n-propylamino)tetralin Sigma-Aldrich, Tocris 9-AC Anthracene-9-carboxylic acid Sigma-Aldrich, Tocris A61603 N-(5-[4,5-dihydro-1H-imidazol-2-y]-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulphonamide hydrobromide Tocris AB-MECA N6-(4-aminobenzyl)-adenosine-5’-N-methyluronamide Sigma-Aldrich ABT-418 (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole Sigma-Aldrich AC187 acetyl-[Asn30,Tyr32]salmon calcitonin Sigma-Aldrich adenophostin A Sigma-Aldrich AFDX384 (7)-5,11-dihydro-11-([{2-(2-N,N-[dipropylamino]methyl)piperidin-1-yl}ethylamino]carbonyl)- Tocris 6H-pyrido[2,3-b](1,4)benzodiazepine-6-one AG-3-5 1-[2-hydroxyphenyl]-4[3-nitrophenyl]-1,2,3,6-tetrahydropyrimidine-2-one Sigma-Aldrich, Tocris AGN192093 (Z)-7-([1a,5a,6a,7b]-7-[{1E,3S}-3-hydroxy-1-octenyl]-3-oxo-2,4-dioxobicyclo[3.2.1]oct-6-yl)-5-heptenol Sigma-Aldrich AH13205 trans-2-(4-[1-hydroxyhexyl]phenyl)-5-oxocyclopentaneheptanoate Sigma-Aldrich AH23848 (1a[z],2b,5a)-(7)-7-(5-[{(1,10-biphenyl)-4-yl}methoxy]-2-[4-morpholinyl]-3-oxocyclopentyl)-4-heptenoate Sigma-Aldrich AIDA 1-aminoindan-1,5(RS)-dicarboxylic acid, also known as UPF523 Sigma-Aldrich, Tocris AM630 6-iodopravadoline Sigma-Aldrich, Tocris AMPA (RS)-a-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid Sigma-Aldrich, Tocris Anandamide Tocris Antalarmin N-butyl-N-ethyl-(2,5,6-trimethyl)-7-[2,4,6-trimethylphenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine Sigma-Aldrich Compound Supplier Apamin Bachem, Sigma-Aldrich ARC239 2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride Tocris Astemizole Sigma-Aldrich Astressin cyc30–33[d-Phe12,Nle21,38,Glu30,Lys33]CRF-(12-41) Sigma-Aldrich, Tocris ATPO (RS)-2-amino-3-(3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid Sigma-Aldrich ATPgS Adenosine 5’-(3-thio)triphosphate Roche, Sigma-Aldrich ATRA all-trans-retinoic acid AZT 30-azido-30-deoxythymidine Sigma-Aldrich BADGE bisphenol A diglycidyl ether Sigma-Aldrich, Tocris BAYu9773 6(R)-(40-carboxyphenyl-thio)-5(S)-hydroxy-7(E),11(Z),14(Z)-eicosatetraenoic acid Sigma-Aldrich Bezafibrate 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid Sigma-Aldrich BHT920 6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-[4,5-d]-azepine Sigma-Aldrich BIBP3226 R-N2-(diphenylacetyl)-N-(4-hydroxyphenyl)methyl-argininamide Sigma-Aldrich BIM23056 dPhe-Phe-Tyr-dTrp-Lys-Val-Phe-dNal-NH2 Tocris BIM23127 D-Nal-cyc[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 Bachem, Tocris BMY45778 3-(4-[4,5-diphenyl-2-oxazolyl]-5-oxazolyl)phenoxyacetic acid Tocris BMY7378 8-(2-[4-{2-methoxyphenyl}-1-piperazinyl]ethyl)-8-azaspiro[4,5]decane-7,9-dione dihydrochloride Sigma-Aldrich, Tocris bosentan Bachem BQ123 cyc(dTrp-dAsp-Pro-dVal-Leu) Sigma-Aldrich BQ3020 N-acetyl-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp Sigma-Aldrich BQ788 N-cis-2,6-dimethylpiperidinocarbonyl-L-g-methylleucyl-D-1-methoxycarboyl-D-norleucine Sigma-Aldrich BRL15572 3-[4-(3-chlorophenyl) piperazin-1-yl]-1,1,-diphenyl-2-propanol Sigma-Aldrich, Tocris BRL37344 sodium 4-(2-[2-hydroxy-3-chlorophenyl}ethylamino]propyl)phenoxyacetate Sigma-Aldrich, Tocris BRL44408 2-(2H-[1-methyl-1,3-dihydroisoindole]methyl)-4,5-dihydroimidazole Sigma-Aldrich, Tocris BRL54443 3-(1-methylpiperidin-4-yl)1H-indol-5-ol Sigma-Aldrich, Tocris BW245C 5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)hydantoin Sigma-Aldrich BW723C86 1-[5(2-thienylmethoxy)-1H-3-indolyl]propan-2-amine hydrochloride Sigma-Aldrich, Tocris BWA868C 3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethylamino)hydantoin Sigma-Aldrich C7 galanin-1–13-spantide Sigma-Aldrich caffeine 1,3,7-Trimethylxanthine Sigma-Aldrich calciseptine Calbiochem Calphostin C Sigma-Aldrich CCPA 2-chloro-N6-cyclopentyladenosine Sigma-Aldrich, Tocris CGP12177A (-)-4-(3-tert-butylamino-2-hydroxypropoxy)-benzimidazol-2-one Sigma-Aldrich, Tocris CGP20712A 2-hydroxy-5-(2-[{2-hydroxy-3-(4-[1-methyl-4-trifluoromethyl-2-imidazolyl]phenoxy)propyl}amino]ethoxy)benzamide Sigma-Aldrich, Tocris CGP35024 3-amino-propyl-(P-methyl)-phosphinic acid, also known as 3-APMPA CGP35348 p-(3-aminopropyl)-P-diethoxymethylphosphinic acid Tocris CGP37849 (RS)-(E)-2-amino-4-methylphosphono-3-pentanoic acid Sigma-Aldrich, Tocris CGP42112A nicotinic acid-Tyr-(N-benzoylcarbonyl-Arg)-Lys-His-Pro-Ile-OH CGP54626 [S-(R,R)]-[3-[[1-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid Tocris CGP55845 3-[-1-(S)-(3,4-dichlorphenyl)-ethyl]amino-2(S)-hydroxypropyl-(P-benzyl)-phosphinic acid Tocris CGP61594 (7)-trans-4-[2-(4-azidophenyl)acetylamino]-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid Sigma-Aldrich CGP62349 [3-[1-R-[[3-(methoxyphenylmethyl)hydroxyphosphinyl]-2(5)-hydroxypropyl]amino]ethyl]-benzoic acid Sigma-Aldrich CGP64213 [3-[-(R)-[[3-5N-[1-[2-[[3-iodo-4-hydroxyphenyl]ethyl]carboxamido]pentyl]hydroxyphosphinyl]-2(S)- Sigma-Aldrich hydroxy-propyl]amino]ethyl-benzoic acid Buyers’ Guide S121 CGP71683A trans-naphthalene-1-sulphonic acid(4-[4-amino-quinazolin-2-ylamino]-methyl)-cyclohexylmethyl-amide hydrochloride Sigma-Aldrich CGS15943 5-amino-9-chloro-2-(2-furyl)1,2,4-triazolo[1,5-c]quinazoline Sigma-Aldrich, Tocris CGS19755 4-phosphonomethyl-2-piperidinecarboxylic acid Tocris CGS21680 2-(4-[2-carboxyethyl]-phenethylamino)adenosine-5’-N-ethyluronamide Sigma-Aldrich, Tocris CGS25019C 4-(5-[4-{aminoiminomethyl}phenoxy]pentoxy)-3-methoxy-N,N-bis(1-methylethyl)benzamide-(Z)-2-butenedioate Sigma-Aldrich charybdotoxin Bachem, Calbiochem chelerythrine Sigma-Aldrich, Tocris S122 Compound Supplier CHPG (RS)-2-chloro-5-hydroxyphenylglycine Sigma-Aldrich, Tocris Buyers’ Guide CI966 (1-[2-{bis-4(trifluromethyl)phenyl}methoxy]ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid Sigma-Aldrich, Tocris CI977 (5R)-(5a,7a,8b)-(–)-N-methyl-N-(7-[1-pyrrolidinyl]-1-oxaspiro[4,5]dec-8-yl)-4-benzofuranacetamide monohydrochloride Sigma-Aldrich ciglitizone (7)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione Sigma-Aldrich, Tocris CL316243 disodium (R,R)-5-(2-[{2-(3-chlorophenyl)-2-hydroxyethyl}-amino]propyl)-1,3-benzodioxole-2,2,dicarboxylate Tocris clofibrate Sigma-Aldrich (may not be available in US due to patent issues), Tocris CNQX 6-cyano-7-nitroquinoxaline-2,3-dione Sigma-Aldrich, Tocris CP101606 (1S,2S)-1-4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol Sigma-Aldrich CP195543 (+)-2-(3-benzyl-4-hydroxychroman-7-yl)-4-trifluoromethylbenzoic acid Sigma-Aldrich CP55940 (-)-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxypropyl)cyclohexan-1-ol Sigma-Aldrich, Tocris CPA N6-cyclopentyladenosine Tocris CPCCOEt cyclopropan[b]chromen-1a-carboxylate