a 2001 GORDON RESEARCH CONFERENCE on MICROBIAL POPULATION BIOLOGY FINAL PROGRESS REPORT *DEPARTMENTOF ENERGY GRANT NO. DE-FG02-01ER63084 The Gordon Research Conference (GRC) on MICROBIAL POPULATION BIOLOGY was held at Williams College from 7/29/01 thru 8/3/01. The Conference was well-attended with 133 participants (attendees list attached). The attendees represented the spectrum of endeavor in this field coming from academia, industry, and government laboratories, both U.S.and foreign scientists, senior researchers, young investigators, and students. In designing the formal speakers program, emphasis was placed on current unpublished research and discussion of the future target areas in this field. There was a conscious effort to stimulate lively discussion about the key issues in the field today. Time for formal presentations was limited in the interest of group discussions. In order that more scientists could communicate their most recent results, poster presentation time was scheduled. Attached is a copy of the formal schedule and speaker program and the poster program. In addition to these formal interactions, "free time" was scheduled to allow informal discussions. Such discussions are fostering new collaborations and joint efforts in the field. I want to personally thank you for your support of this Conference. As you know, in the interest of promoting the presentation of unpublished and frontier-breaking research, Gordon Research Conferences does not permit publication of meeting proceedings. If you wish any further details, please feel free to contact me. Thank you. Sincerely. LIN CHAO UNIVERSITY OF CALIFORNIA, SAN DlEGO DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor my agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes my legal liability or responsibility for the accuracy, completeness, or use- fulness of any information, apparatus, product. or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any spc- cific commercial product, process, or service by trade name, trademark, manufac- turer, or otherwise docs not necessarily Epnstitute or imply its endorsement, ream- mendation, or favoring by the United States Government or any agency thereof. Pht vim and opinions of authors expdherein do not necessarily state or reflect those of the United States Government or my agency thereof. DISCLAIMER Portions of this document may be illegible in electronic image products. Images are produced from the best available original document. Microbial Population Biology Williams College Williamstown, MA JuI 29-Aug 3,2001 Lln Chao, Chair Siv Andersson, Vice-Chair Sunday, July 29,2001 Microbial communities and societies Discussion Leader: Sebastian Bonhoeffer William Costerton Montana State University Bacterial biofilms as integrated communities Joan Stassmann Rice University Social conflict in the social amoeba, Dictyostelium discoideum Sebastian Bonhoeffer ETH Zurich Cooperation and competition in the evolution of ATP-producing pathways Bonnie Bassler Princeton University How Bacteria Talk To Each Other: Regulation of Gene Expression by Quorum Sensing Monday, July 30,2001 Viral evolution I Discussion Leader: Esteban Domingo Mary Poss University of Montana Feline immunodeficiency virus evolution as an indicator of population dynamics of wild felid hosts Esteban Domingo Universidad Autonoma de Madrid Memory and extinction in viral quasispecies Teny Hwa University of California San Diego Molecular evolution and the statistics of regulatory DNA motifs Christina Burch Princeton University Increased environmental and mutational sensitivity with increased fitness in the bacteriophage phi6 John Yin University of Wisconsin Probing genetic interactions in phage T7 by in silico mutagenesis Mutational effects and evolution Discussion Leader: Rosemary J. Redfield Rosemary J. Redfield University of British Columbia Putting sex in context; why bacteria take up DNA Christian Schlotterer Veterinarmedizinische Universitat Wien Tracing beneficial mutations in E. coli with a polymorphic microsatellite marker Jeffrey H. Miller University of California, Los Angeles Mutators in cell populations Ivan Matic INSERM Faculte de Medecine-Necker High incidence of strong inducible mutators among E. coli natural isolates Tuesday, July 31,2001 Ecology and evolution of infectious diseases Discussion Leader: Bruce Levin Bruce Levin Emory University Mutation, evolution, and the within-host population dynamics of bacterial infections Marc Llpsitch Harvard School of Public Health The rise and fall of antimicrobial resistance: what determines how fast resistance changes following changes in the pattern of antimicrobial use? Margaret Riley Yale University Addressing resistance in antimicrobial design Janis Antonovics University of Virginia Ecology and evolution of sexually transmitted diseases Microbial genetics and genomics Discussion Leader: Howard Ochman David Guttman University of Toronto An in vivo screen for type 111 effector proteins in the phytopathogen pseudomonas syringae Joseph Pogliano University of California, San Diego Visualization of replication and partitioning of plasmid DNA during bacterial mitosis Jonathan A. Eisen The Institute for Genomic Research Microbial genome evolution and the benefits of phylogenomic analysis: or why all genome projects need an evolutionary biologist Howard Ochman University of Arizona Bacterial Genomics: Promise and prospects Wednesday, August 1,2001 Model systems: theory and experiments I Discussion Leader: Michel Blot Christopher Adam1 California Institute of Technology Digital Organisms for Experimental Evolution Vaughn Cooper University of Michigan Adaptation, specialization and constraint in evolving E. coli populations Michel Blot Universite J. Fourier Multi-evidence for IS-borne genomic adaptation in E. coli Anthony Dean University of Minnesota Form, function and fitness: a molecular guide Jeff Lawrence University of Pittsburg Fishbait, unnatural death and the evolution of antigenic diverslty in salmonella Model systems: theory and experiments II Discussion Leader: Daniel Dykhuizen Stanislas Leibler Princeton University Motility and chemotaxis of bacteria: theory and experiments Jamie Glllooly University of New Mexico Biological Time: Effects of mass and temperature on population growth in microbes and other organisms Martin Ackermann University of Basel Senescence and Life History Evolution in a Bacterium Thursday, August 2,2001 Viral Evolution Il Discussion Leader: Simon Wain-Hobson Robin Bush University of California lrvine Predicting influenza evolution lgor Rourine Tufts University Crossover between stochastic and deterministic behavior of evolution: an analytic review and applications to virology Minghsun Liu University of California, Los Angeles Reverse transcriptase-mediated diversity in host-parasite interactions: tropism switching by bordetella bacteriophage Simon Wain-Hobson lnstitut Pasteur HIV and RNA viruses change more than they evolve Keith Crandall Brigham Young University The relationship between genetic diversity of HIV and disease progression towards AIDS Microbial Eukaryotes Discussion Leader: Michele Dubois Michele Dubois Fred Hutchinson Cancer Research Center How are yeast chromosome ends protected? Heather True-Krob The University of Chicago Biological Significance of the Yeast Prion [PSI+] Laura Landweber Princenton University Evolution of gene scrambling and RNA editing in microbial eukaryotes Copyright 0 2001 Gordon Research Conferences Last Updated: 8/24/01 by Jeff Carroll MICROBIAL POPULATION BIOLOGY Williams College, Williamstown, MA (29J~l-01)- (03-Aug-01) NOTE: Rerzipt of Application does not guarantee acceptance to a Conference. Applications are reviewed by the Conference Chair. If the Chair approves your application, you become Accepted, and a registration packet will be mailed immediately. Please allow 3-5 days for your registration to reach you by mail once your name appears. When your registration packet has been received back In our office. you become Registered. Only those who have been Accepted or Reglstered will have their names listed below. Names of people who have only applied and have yet to be accepted will NOT appear. Name Organization Participation Status STEPHFN T ABEDON OHIO STATE UNIVERSITY Poster Presenter Registered MARK ACHTMA N MAX PLANCK INSTITITE FOR INFECTIOUS BIOLOGY Attendee Registered MARTIN ACKERMANN UNIVERSITY OF BASEL Speaker Registered CHRIS ADAM1 CALlFORNlA INSTITUTE OF TECHNOLOGY Speaker Registered UnORY UNIVERSITY Poster Presenter Registered DAN- IANDERSSO N SWEDISH INST FOR INFECTIOUS DISEASE CONTROL Poster Presenter Registered SIV G E ANDERSON UPPSALA UNIVERSITY Vice Chair Registered JANIS ANTONOWCS UNIVERSITY OF WRGlNlA Speaker Registered UNIVERSITY OF UPPSALA Poster Presenter Registered -FARlDA VATTAR MEDICAL COLLEGE OF OHIO Poster Presenter Registered JAMIE M BACHER UNIVERSITY OF TEXAS ATAUSTIN Poster Presenter Registered IES BAILLIE DERA PORTON DOWN Speaker Registered NATHALIE Q BALABAN PRINCETON UNIVERSITY Attendee Registered BONNIE BASS LER PRINCETON UNIVERSITY Speaker Registered JACOB BAUM LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE Attendee Registered $J4klEu MICHIGAN STATE UNIVERSITY Attendee Registered ALBFRT F BENNI3-T UNIVERSITY OF CALIFORNIA Poster Presenter Registered UNIVERSITY OF WASHINGTON Poster Presenter Registered MOMAS-