DED 8-199 UN 18 189 8 O 98 F yyyy N N yyyy Y Y O O T T R R E E I I T T C H C H E O E O yyyyN N A E S A E S S S S L S L T T A A E A E A C C R C I R C I yyyyN S M N S M S E S E E H E H C C C C T N T N IO A January 2007IO A Vol. LXXXV, No. 5 yyyyC C N • AMERI N • AMERI Monthly Meeting A First-Time Mentor Joint Meeting with BAGIM NEBHE Science Network by Jin Ji Chair’s Statement Summer Research Scholar By Mukund Chorghade Design and Synthesis of Novel Inhibitors of Dihydroorotase 2007 Chair’s Statement By Mukund Chorghade It is a singular honor and privilege to ing several prominent scientists has between the medicinal and process assume the office of Chair for the been arranged on March 30. This could chemistry groups and facilitate via Northeastern Section. The breadth, be the forerunner of an annual Life Sci- symposia and discussion groups new depth and sophistication of the talent ences Symposium and could provide a perspectives on the progress of a drug and creativity of the individuals in the useful forum for productive exchange from conception to commercialization. section are truly outstanding. We have of ideas. (2) Encourage a vitalized (5) Organize a few lunch time lectures eminent researchers and professionals speakers bureau to provide guest lec- to attract researchers who, because of representing the strategic triad of aca- tures to schools, universities and civic their busy schedules, are not able to demia, government and industry from and community groups. The topics can attend the evening lectures. The ACS all sub-disciplines of chemistry. We encompass issues of topical interest, has novel programs like the science enjoy a cherished and hallowed tradi- e.g., chemical safety, environmental café’s that will be of great interest to tion of excellence. The warmth and and the contributions made by our members. (6) Increase participa- gracious hospitality with which we chemists/chemistry to the benefit of tion of members in the section activi- welcome participation by our mem- society at large. (3) Expand the activi- ties and increase the membership of bers, collaborators and distinguished ties of the Professional Training/Educa- the ACS and the section. This will also guests has been the hallmark of our tion and Career Services committees. allow greater opportunities for net- tradition and the well-spring of our Regular workshops will be used to edu- working among chemists. Greater progress cate students at local colleges/universi- emphasis will be placed on attracting It will be my endeavor to (1) Fos - ties and mid-career professionals about chemists in the biotechnology / bio- ter greater interactions between the the diverse opportunities in chemistry, pharmaceutical industries and partici- ACS and the other professional bodies current trends in globalization, resume pation of their employers via corporate catering to the cause of chemistry - writing, interviewing skills/techniques sponsorships (7) Stimulate additional The American Institute of Chemists and related topics. Such workshops participation of the section in the inter - and the International Union of Pure will also benefit mid-career and national activities of the ACS. Our and Applied Chemistry come readily to chemists undergoing a career transi- members are involved in a wide array mind. A one-day joint meeting featur- tion. (4) Build a much-needed bridge continued on page 16 2 The Nucleus January 2007 The Northeastern Section of the American Chemical Society, Inc. Contents Office: Marilou Cashman, 23 Cottage St., Natick, MA 01360. 1-800-872-2054 (Voice or FAX) or 508-653-6329. 2007 Chair's Statement _________________________________2 e-mail: mcash0953(at)aol.com Any Section business may be conducted By Mukund Chorghade via the business office above. NESACS Homepage: Grants-In-Aid and Career Services 4 http://www.NESACS.org _________________________ Sathish Rangarajan, Webmaster ACS Hotline, Washington, D.C.: Monthly Meeting _______________________________________5 1-800-227-5558 Joint with BAGIM, Yvonne Martin to Speak on "Lessons from 41 Years as a Officers 2007 Computational Chemist" Chair: Mukund Chorghade 14 Carlson Circle, Natick, MA 01360 Second Heyn Book Award________________________________6 508-651-7809 and 308-3891 Chorghade(at)comcast.net A First-Time Mentor 6 Chair-Elect: ____________________________________ Marietta Swartz NEBHE Science Network by Jin Ji Chemistry Department, Umass-Boston Boston, MA 02125 Report from Seoul 7 617-287-6146; marietta.swartz(at)umb.edu _____________________________________ Immediate Past Chair: By Morton Z. Hoffman Patricia Mabrouk Chemistry Department, Northeastern University Summer Research Scholar 8 Boston, MA 02115 _______________________________ 613-373-2845; p.mabrouk(at)neu.edu Design and Synthesis of Novel Inhibitors of Dihydroorotase by Secretary: Kerry Heinzelmann and Evan Kantrowitz Michael Singer Sigma-Aldrich 3 Strathmore Rd., Natick, MA 01360 National Chemistry Week Report _________________________10 508-651-8151X291; msinger(at)sial.com Treasurer: Connections to Chemistry ______________________________11 James Piper 19 Mill Rd., Harvard, MA 01451 978-456-3155, piper28(at)attglobal.net Cover: From L-R: Evan Heyn, Mary Mahaney, Chair of the NESACS Board of Auditor: Publications, Vincent Gale, Advertising Manager of the Nucleus and recipient of Anthony Rosner the second Arno Heyn Memorial Book Award, Michael P. Filosa, Editor of the Archivist: Myron S. Simon Nucleus, Vivian Walworth, Board of Publications, Robert Heyn and Janice Heyn. 20 Somerset Rd. Newton, MA 02465; 617-332-5273 Deadlines: March 2007 Issue: January 10, 2007 Romysimon(at)mindspring.com Trustees: April 2007 Issue: February 12, 2007 Joseph A. Lima, Esther A. H. Hopkins, Michael E. Strem Councilors Alternate Councilors Term Ends 12/31/2007 Thomas R. Gilbert Arlene W. Light Michael J. Hearn Timothy B. Frigo The Nucleus is distributed to the members of the Northeastern Section of the American Chemical Michael Singer Mary Mahaney Society, to the secretaries of the Local Sections, and to editors of all local A.C.S. Section publications. Pamela Nagafuji Mark Froimowitz Forms close for advertising on the 1st of the month of the preceding issue. Text must be received by the Term Ends 12/31/2008 editor six weeks before the date of issue. Doris I. Lewis Patrick M. Gordon Morton Z. Hoffman Michael P. Filosa Editor: Michael P. Filosa, editor, Ph.D., ZINK Imaging Incorporated, 1265 Main Street, Christine Jaworek-Lopes Lawrence Scott Waltham, MA 02451 Email: Michael.Filosa(at)zink.com; Tel: 781-386-8479. Mary Burgess Liming Shao Associate Editors: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 613-332-5273 Donald O. Rickter S.B. Rajur Nancy Simons, Analytical Chemist, Corporate R&D, Boston Scientific Corp., Term Ends 12/31/2009 1 Boston Scientific Place A4, Natick, MA 01360-1537. Catherine Costello Julia H.Miwa Email: Nancy.Simons(at)bsci.com; Tel. 508-650-8603; Fax 508-647-2329 Patricia Mabrouk Alfred Viola Sheila E Rodman, Konarka Techologies Inc., 116 John St. Suite 12, Lowell, MA Michaeline F. Chen Wallace J. Gleekman 01852 email:srodman(at)konarka.com tel 978-569-1414 Dorothy J. Phillips Eva B. Binnun Amy Tapper Barney Grubbs Board of Publications: Mary Mahaney (Chair), Martin Idelson, Vivian K. Walworth Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, Tel: 978-456-8622 All Chairs of standing Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050, Committees, the editor Tel: 781-837-0424; FAX: 781-837-1453 of THE NUCLEUS, and Contributing Editors: Morton Hoffman, Feature Editor; Dennis Sardella, Book Reviews; the Trustees of Section Calendar Coordinator: Sheila Rodman, email: srodman(at)konarka.com Funds are members of the Photographers: Morton Z. Hoffman and James Phillips Board of Directors. Any Councilor of the American Chemical Society Proofreaders: Donald O. Rickter, Myron S. Simon, Vivian K. Walworth residing within the section area is an ex officio Webpage: Webmaster: Sathish Rangarajan, sathish.rangan2(at)gmail.com member of the Board of Directors. Copyright 2006, Northeastern Section of the American Chemical Society, Inc. The Nucleus January 2007 3 Grants-in-Aid NESACS Corporate Patrons and Golf Iridium Astra Zeneca R&D Boston Awarded to Career Genzyme Drug Discovery & Dev Hovione IBM Under- Services at IRIX Pharmaceuticals Johnson-Matthey Pharma Solutions graduates Monthly Lyophilization Service of New Eng- land Merck The Education Committee has awarded Meetings Phasex Corporation Grants-in-Aid of $250 each to four The NESACS Career Services Com- Sepracor undergraduates at colleges and univer- Strem Chemicals, Inc. mittee is dedicated to providing ACS sities within the Northeastern Section Zone Enterprises Members with the best tools to manage to enable them to attend the ACS Corporate Sponsors and Golf National Meeting in Chicago, Illinois careers. We offer career guidance and focus on the components needed for Rhodium to present a paper at the Under graduate Aerodyne Research, Inc. Research Poster Session in the Division targeting the job market: personal assessment, identifying market trends, Cambridge Isotope Laboratories of Chemical Education on Monday, Cambridge Major Laboratories credentials, research and networking. March 27, 2007. Matching funds have New England BioLabs, Inc. been committed by the institutions to We have a comprehensive (lecture, Pfizer support the students’ travel. The recipi- demo and review) program that pro- Sigma-RBI ents are also required to participate in vides assistance in writing winning Shasun Pharma Solutions the Northeast Student Chemistry resumes and cover letters as well as various techniques and skills needed Donors and Golf Tungsten Research Conference (NSCRC) in Consulting Resources Corp. April 2007. for a successful interview. Dishman Pharmaceuticals In collaboration with the Speaker’s The awardees, their research supervi- And Chemicals Limited Bureau, we will organize a program of sors, and the titles of the papers are as Houghton Chemical Company resume reviews and short lectures follows: Organix, Inc.