Medical Research Archives, Vol. 5, Issue 7, July 2017 Masseter Treatment with Botulinum Toxin A for parafunctions and quadralized patients Masseter Treatment with Botulinum Toxin A for parafunctions and quadralized patients Authors: Abstract Redaelli A.1 INTRODUCTION Battistella M.2 Botulinum toxin type A (BTxA) has gained worldwide popularity due to its ability to improve the lower facial contours and treat Affiliations: parafunctions. 1 Department of phlebology MATERIALS AND METHODS and aesthetic medicine, Various analyses have been conducted through Medline searches Visconti di Mondrone Medical for “Botulinum”, “masseter” and “bruxism” in order to investigate Center, Milan, Italy the different techniques used to inject the masseter muscle with 2 Clinical Research Coordi- Botulinum toxin. The authors’ experiences and techniques are nator; Biobasic Europe, Milan, fully explained regarding both functional pathologies and Italy. masseter size reduction. Personal guidelines to help physicians achieve the best outcomes for each application are outlined. Corresponding address: Even if a definitive consensus on the use of Botulinum toxin for masseter muscle treatment cannot be reached, the authors Battistella M. recommend, due to their experience, three injection sites per side E-mail: of the face for masseter hypertrophy and four injection sites per [email protected] side for the redefinition of the inferior third of the face. Fewer units are needed to inhibit bruxism, while more units are needed DISCLOSURE: in order to achieve a reduction in muscle size. Redaelli Alessio is a repre- RESULTS sentative and trainer for Ipsen Results have been very good and patient satisfaction is usually and Filorga companies. His very high. No side effects have been experienced as of the writing books have been published by of this report. OEO Firenze. DISCUSSION Battistella Melania is a representative and trainer for BTxA can be used as a therapeutic agent in bruxism patients and General Project and Wavemed has been widely accepted as a cosmetic agent in recent years, companies. helping to re-establish a balance in the contours of quadralized patients due to its positive clinical outcomes. Other clinical KEYWORDS: investigations are needed to improve the long-term effectiveness of Botulinum toxin. Botulinum toxin A, masseter, bruxism, masseter reduction, CONCLUSION quadralized patients, masseter Botulinum toxin can be considered a safe and effective technique hypertrophy to treat related masseter parafunctions and to improve the shape of the lower face in quadralized patients. Copyright 2017 KEI Journals. All Rights Reserved Page │1 Medical Research Archives, Vol. 5, Issue 7, July 2017 Masseter Treatment with Botulinum Toxin A for parafunctions and quadralized patients 1. INTRODUCTION masseter, i.e., before and after dental (1, 2) Bruxism is a serious psycho- implants . The authors’ experiences and physiological disorder and a common casistic report on bruxism were published some years ago, detailing excellent results clinical issue in dentistry: it is defined as the (3) clenching, grinding, gnashing and tapping of and zero side effects . the teeth. It is often classified as either In cosmetic medicine, its use is diurnal (occurring while the individual is indicated to reduce the volume of the awake) or nocturnal (occurring while the masseter muscle(4) and to improve the individual is sleeping). aesthetics of the face and the expressive (5,6) It is also well known that bruxism wrinkles . In fact, aesthetic canons of causes tooth displacement, TMJ disorders beauty continue to influence many cultures, and alterations in periodontal sensitivity. so triangular and heart shaped faces are still considered delicate and fascinating A variety of therapeutic options have compared to quadralized faces with enlarged been proposed for bruxism (functional and lower contours. drug therapy) even though there is no unanimous consensus on the best treatment. This is why the authors normally Botulinum Toxin type A (BTxA) is a follow the rule that inter-jugal distance powerful known biological toxin - safe and should be 82% of bizygomatic distance. effective - which has long been used for Assuming that the bizygomatic distance is different purposes in medicine. In modern 100%, quadralized patients have a very dentistry, BTxA technique is also used to similar bigonian distance. In rare patients, control masticatory muscles and postsurgical most often males, the bigonian distance is pain, in particular the temporalis and the higher than the bizygomatic distance. Figure 1: in (a) pre-treatment and in (b) 30 days post-treatment. Assuming that the bizygomatic distance is 100%, it is easy to assess the improvement of the bigonian distance Copyright 2017 KEI Journals. All Rights Reserved Page │2 Medical Research Archives, Vol. 5, Issue 7, July 2017 Masseter Treatment with Botulinum Toxin A for parafunctions and quadralized patients A wide lower third of the face is a standard BTxA administration that could caused by many factors, but primarily by achieve better aesthetic results for the lower prominent mandibular angles and muscle facial contour and for parafunction control. hypertrophy. There is no consensus on the The authors have used Abobotulinum units required to obtain positive results in Toxin A in their day-to-day practice for the bruxers. last 10 years. In Italy, the commercial name The purpose of this article is to of Abobotulinum Toxin A (AboTA) is recommend the best dosage to use in both Azzalure and for Bruxers the average cosmetic and functional masseter treatments, dilution used is 0,75 ml of normal saline based on the evaluation of the literature and (slightly higher than the dose used for the authors’ experience. aesthetic purposes). In this dilution (3 ml for 500 IU Dysport), 5U are in 0,03 ml and 20 U 2. MATERIALS AND METHODS in 0,12 ml. For Bruxers, 3 sites are injected with a total of 35UI = 0,21 ml (10+10 in the The authors revised the literature using lower sites and 15U in the highest) (Fig.1) (3) Medline as their main source, inserting while in quadralized patients, where the “botulinum toxin,” “bruxism”, and reduction of muscle size is the goal, we “masseter” as search criteria. All the studies normally inject 4 sites (20U x point = 0,12 responding to the criteria have been taken ml) for a total of 80U (0,48 ml) per side into consideration in an attempt to establish (Fig.2). simple guidelines with the aim of suggesting Figure 2: in (a) the injection sites for bruxism and in (b) those for masseter hypertrophy The ideal botulinum injection site in we inject the dosage as we push the needle the masseter is a rectangular area precisely into the muscle. In this way, we can avoid in the center of the muscle: to avoid the diffusion of the toxin into the Risorius Stenson’s Duct we remain always at least 1 muscle, which is superficial and sometimes cm below a line from the Tragus to the upper presents laterally in parotideal fascia – very lip. Then we accurately map the masseter close to the masseter. muscle in the anterior and posterior edge by To perform this technique: asking the patient to clench their teeth. We select 3 or 4 sites precisely in the center of - reconstitute the toxin with the the muscle according to this reference. These suggested dilution (normally 3 ml normal injections must be done in a particular way: saline for 500U AboTA), the needle is inserted while the patient - aspirate the correct amount of clenches their teeth and then, as they relax, Units in a 0,5 ml insulin syringe with a Copyright 2017 KEI Journals. All Rights Reserved Page │3 Medical Research Archives, Vol. 5, Issue 7, July 2017 Masseter Treatment with Botulinum Toxin A for parafunctions and quadralized patients 30G x 8mm needle used various times to demonstrate clearly - ask the patient to simulate biting in and statistically significant post-injection order to identify masseter muscle mass masseter reduction. - palpate the muscle to identify the There is still some controversy major contraction points regarding the injection sites and the quantity of toxin that must be used. Some studies - mark three or four sites, as shown in reported five intra-muscle injection sites on Figure 2, according to this indication both sides using a 29 gauge needle (13); - insert the 30G 8mm needle in the others, conducted on facial dissections center of the contracted muscle suggest three sites per side using different dosages of the toxin. (14,15) - ask the patient to relax, applying light pressure so that the needle remains in the Some authors have found that the final center of the muscle measurement of muscle mass following intermittently repeated treatments resulted in - inject the units into each site a long-lasting reduction. (16) Based on this knowledge, the authors 3. RESULTS have – over time – refined their techniques The efficacy of BTxA in reducing the for treating masseter hypertrophy during volume of the masseter muscle has been their practice. Regarding lower face contour proven by many studies using different remodeling with AboTA, they suggest some injection protocols to confirm its efficacy simple steps as the ideal approach for beyond the results seen in photographs and masseter treatment, as previously outlined. to attain an assessment of patient Masseter hypertrophy can be satisfaction. symmetrical or asymmetrical. As mentioned Initially, physicians were primarily above, it is possible to treat this aesthetic interested in analyzing the expression of the complaint modulating the quantity of proteins involved in the process of muscle botulinum toxin injection, considering the reduction in animal (7) and human different needs of each patient. (8) specimens. As always, a strong knowledge of Many authors have investigated the anatomy is essential as is an understanding effects of BTxA using electromyography of the physical structures if the aim is to (EMG) in animal subjects (9), confirming that administer an effective botulinum toxin masseter muscle activity measured by EMG injection and avoid a potentially iatrogenic was immediately decreased after a BTX-A unnatural facial expression.