Organization in Special Consultative Status with the UN Economic and Social Council www.allianceforum.org/en 2014 World Alliance Forum in San Francisco The Impact of Regenerative Medicine 2014 Mission Bay Conference Center at UCSF November 6 - 7, 2014 Organized by: Alliance Forum Foundation Government of Japan (Consulate General of Japan in San Francisco) www.wafsf.org Table of Contents Page Greetings 3 Program 6 Speakers’ Biography 12 Masters of Ceremonies’ Biography 26 Sponsors & Major Supporting Organization 27 2 Greetings Organization in Special Consultative Status with the UN Economic and Social Council Greetings from George Hara Chairman of the Board, Alliance Forum Foundation The Alliance Forum Foundation began holding its annual World Alliance Forum in the 1990s with a goal to nurture emerging technologies in the fields of IT and healthcare. Since then, the Forum has continued to be a catalyst for many new alliances among businesses, research institutions, governments, and local and international organizations that enable commercialization of innovative technologies. Last year, at the 2013 Forum, the Foundation invited leading researchers engaged in stem cell research in Japan and the US to come together in San Francisco. In the festive atmosphere of celebrating Dr. Shinya Yamanaka and his 2012 Nobel Prize in Physiology or Medicine, participants gave presentations on this new stage in the development of regenerative medicine made possible by Dr. Yamanaka's discovery of induced pluripotent stem cells (iPSC). It became clear at that Forum that this revolutionary technology will change not only our healthcare system but impact our society in the most fundamental way. At this year's Forum--The Impact of Regenerative Medicine 2014--I look forward to seeing more than forty leading researchers and business leaders from the US, Japan and other parts of the world come together to discuss current developments in clinical applications in stem cell therapeutics and share information which is vital to building social consensus towards developing stem cell research and regenerative medicine. We will also hear about exciting opportunities for investors and businesses in this burgeoning field. It is my hope that as new and existing businesses achieve success, a portion of the profits will be directed back to funding further research in the spirit of public interest capitalism so that stem cell technology may continue to make huge strides toward becoming a new economic engine of industrial growth for the benefit of all. I thank all the presenters who are coming together to make The Impact of Regenerative Medicine 2014 a valuable and important program of shared expertise and dialogue. I also want to recognize the generosity of our sponsors which made this year's Forum possible. Ambassador George Hara Special Advisor to the Cabinet Office of the Prime Minister of Japan Chairman of the Board, Alliance Forum Foundation 3 Masato Watanabe Consul General of Japan in San Francisco Message from Masato Watanabe With the significant recent progress that has been made in the field of regenerative medicine, it is hard to believe that only a year has passed since our last meeting was held here in San Francisco. As an example of this progress, last month in Kobe, Japan, we saw the first iPS cell transplanted into a human body. This marks the first time in the world this type of surgery has taken place, and symbolizes a big leap towards the practical use of regenerative medicine. In an effort to further advance this field, the Japanese government last year legislated three acts regarding regenerative medicine, that is, the Regenerative Medicine Promotion Act, the Regenerative Medicine Safety Act, and the Medicines and Medical Devices Act. The Promotion Act has already been enacted and the other two acts will be enacted on November 25th of this year. Additionally, a new R&D management organization, Japan Agency for Medical Research and Development or A-MED, will be established in April 2015, and will serve to emulate the system of the National Institutes of Health in the United States. The Japanese government is planning to increase the R&D budget by 15%, which will be managed by A -MED. In order to further promote this innovative technology, it is essential for academia, industry and policy makers to work collaboratively. Since 1860, when Japan’s first envoy to the United States arrived, San Francisco has been characterized as a symbol of the Japan-US relationship. We sincerely hope that this forum will help to create new technologies and products for the next generation of regenerative medicine. Masato Watanabe Consul General of Japan in San Francisco 4 Event Summary 2014 World Alliance Forum in San Francisco Theme: The Impact of Regenerative Medicine 2014; From the Laboratory to Clinical Application Date & Time: Thursday, November 6th, 2014 9:00 am – 5:10pm (Reception: 5:30 pm – 7:00 pm) Friday, November 7th, 2014 9:00 am – 4:45 pm (Reception: 4:45 pm – 6:00 pm) Location: Mission Bay Conference Center at UCSF 1675 Owens Street, San Francisco, CA 94143 Organizers: Alliance Forum Foundation (AFF) Government of Japan (Consulate General of Japan in San Francisco) Gold DEFTA PARTNERS Sponsors: Mitsui Fudosan Co., Ltd. ROHTO Pharmaceutical Co., Ltd. Takeda Pharmaceutical Company Ltd. MUFG Union Bank Silver Astellas Pharma Inc. Sponsors: Chugai Pharmaceutical Co., Ltd. Bronze Cellular Dynamics International Sponsors: Juventas Therapeutics, Inc. Lonza Walkersville, Inc. MEDIPOST Co., Ltd. Megakaryon Corporation Yorozu Law Group Wi-Fi Sponsor: Lonza Walkersville, Inc. In-Kind AlphaGraphics Sponsors: Ms. Tomoko Tsuji (IKENOBO Flower Arrangement) Major Alliance for Regenerative Medicine (ARM) Supporting BayBio Organizations: California Institute for Regenerative Medicine CIRM California Institute for Quantitative Biosciences (QB3) Center for iPS Cell Research and Application (CiRA), Kyoto University Forum for Innovative Regenerative Medicine (FIRM) Gladstone Institutes Hara Research Foundation The Japanese Society for Regenerative Medicine (JSRM) Supporting Alliance Forum Executive Club Organizations: Japan Bio Community (JBC) Japan Society of Northern California Japanese Chamber of Commerce of Northern California (JCCNC) Japanese University Network of the Bay Area (JUNBA) Keizai Society Student Society for Stem Cell Research (SSSCR) US-Asia Technology Management Center at Stanford University Advisory (Chair)Mr. Hiro Ogawa, Chair, Global Advisory Committee, International Society for Stem Cell Research Board: Dr. Ken-ichi Arai, MD, PhD, Professor Emeritus and former Dean of the Institute of Medical Science, The University of Tokyo (IMSUT), Founder & Chairman, SBI Biotech, Co., Ltd. Dr. Regis Kelly, Director, California Institute for Quantitiative Biosciences (QB3) Dr. Henry A. McKinnell, Jr., former Chairman and CEO of Pfizer, Inc. Dr. Hiromitsu Nakauchi, Professor, Stanford University 5 Program (Thursday, November 6, 2014) Day 1 – Morning: Thursday, November 6 Master of Ceremonies Elona Baum, Esq., VP, Ass. General Counsel, Coherus BioSciences, Inc. (former General Counsel & Vice President of Business Development, California Institute for Regenerative Medicine (CIRM) 8:20–9:00 Conference Registration 9:00–9:10 Opening & Welcome Remarks: Isao “Steve” Matsuura, Conference Co-chair and Council Member, Alliance Forum Foundation The Honorable Masato Watanabe, Consul General, The Consulate General of Japan in San Francisco THE LANDSCAPE OF STEM CELL RESEARCH AND REGENERATIVE MEDICINE Session I Regenerative Medicine 2014 Session Chair: Michael Werner 9:10–10:40 Opening Address: "The State of the IndustryーProgress, Promise, and Challenges" Michael Werner, Executive Director, Alliance for Regenerative Medicine (ARM) Presentations: "My Journey Advocating for Stem Cell Research and Cures" Roman Reed, President, Roman Reed Foundation; Chairman, The Alabama Institute of Medicine; President, Sacred Cell Research Partners “A Nonprofit Biotech's Role in Accelerating Cures through Stem Cell Research” Susan L. Solomon, JD, CEO, New York Stem Cell Foundation "Realizing the Promise of Stem Cell Research" Arlene Chiu, PhD, Director, Office of New Research Initiatives, Beckman Research Institute, City of Hope “Ten @ Ten & CIRM 2.0: How the Numbers Tell the Story” Jonathan Thomas, PhD, JD, Chair, Governing Board of the CIRM (Independent Citizens Oversight Committee) “Development of Japanese Regenerative Medicine Industry” Yuzo Toda, Representative Director, Chairman, Forum for Innovative Regenerative Medi- cine Discussion moderated by Michael Werner: Roman Reed, Arlene Chiu, Susan L. Solomon, Jonathan Thomas,and Yuzo Toda 10:40–10:55 Coffee Break 6 Program (Thursday, November 6, 2014) Session II Business Perspectives on the Regenerative Medicine Space Session Chair: Elona Baum 10:55–11:50 Panel Discussion moderated by Elona Baum, Esq., VP, Ass. General Counsel, Coherus BioSciences, Inc. (formerly VP, General Counsel and Business Development, CIRM): Rahul Aras, PhD, President and Chief Executive Office, Juventas Therapeutics Edward Lanphier, President and CEO, Sangamo BioSciences Inc. Jay Lee, PhD, Senior Director, Business Development, MEDIPOST Co., Ltd. Emile Nuwaysir, PhD, COO, Cellular Dynamics International 11:50–12:10 Company Presentations: ROHTO Pharmaceutical Co., Ltd., Katsuya Hisamichi, MD, Executive Officer Maxcyte, Inc., Madhusudan V. Peshwa, PhD, Executive Vice President, Cellular Therapies 12:10–13:00 Complimentary Lunch in the Fischer Banquet Room (1st Floor)