Seized Drugs Training Guide for General Analysis Comparative and Analytical Division Seized Drugs Training Guide for General Analysis Comparative & Analytical Division Table of Contents 1. INTRODUCTION AND GENERAL ORIENTATION ..................................................................................... 3 2. CONTROL OF DRUGS OF ABUSE .......................................................................................................... 11 3. CHEMICAL CLASSIFICATION OF DRUGS............................................................................................... 16 4. PHARMACEUTICAL IDENTIFICATION OF DRUGS ................................................................................. 27 5. CHEMICAL SPOT TESTS ........................................................................................................................ 30 6. ULTRAVIOLET/VISIBLE SPECTROPHOTOMETRY .................................................................................. 33 7. SEPARATIONS AND EXTRACTIONS ...................................................................................................... 45 8. FOURIER TRANSFORM INFRARED SPECTROSCOPY ............................................................................. 55 9. THIN LAYER CHROMATOGRAPHY ....................................................................................................... 70 10. GAS CHROMATOGRAPHY/MASS SPECTROMETRY .............................................................................. 77 11. ANABOLIC STEROIDS ........................................................................................................................... 96 12. ANALYSIS GUIDELINES ....................................................................................................................... 102 13. EVIDENCE HANDLING ........................................................................................................................ 105 14. REPORTING OF RESULTS ................................................................................................................... 108 15. CASE FILE DOCUMENTATION ............................................................................................................ 110 16. MONITORED ANALYSIS ..................................................................................................................... 112 17. TRAINEE EVALUATION – COMPETENCY SAMPLES ............................................................................ 114 18. TRAINEE EVALUATION – FINAL WRITTEN EXAMINATION ................................................................. 117 19. MODIFICATION SUMMARY ............................................................................................................... 129 Training Guide for General Analysis Document ID: 12013 Issued By: Section Manager Issue Date: June 11, 2018 Uncontrolled When Printed Page 2 of 129 Seized Drugs Training Guide for General Analysis Comparative & Analytical Division 1. INTRODUCTION AND GENERAL ORIENTATION TRAINING SYLLABUS AND CHECKLIST FOR GENERAL ANALYSIS Trainee____________________________________________ Employee Number_______________________ Trainer____________________________________________ Date Training Begins_____________________ Date of Trainer & Receipt or Trainee Topics Completion Initials 1 – General Information Receive Training Guide for General Analysis ___________ ____________ Review of Training Syllabus and Checklist ___________ ____________ Review of Training Guidelines ___________ ____________ 2 – Control of Drugs of Abuse Independent Reading ___________ ____________ Review following sections: Section 2 Material ___________ ____________ History of Federal Drug laws and Controlled Substances Act ___________ ____________ Current Texas Health and Safety Codes including Chapters 481-486 and Controlled Substance Schedules ___________ ____________ 3 – Chemical Classification of Drugs Independent Reading ___________ ____________ Review Section 3 Material ___________ ____________ 4 – Pharmaceutical Identification of Drugs Independent Reading ___________ ____________ Training Guide for General Analysis Document ID: 12013 Issued By: Section Manager Issue Date: June 11, 2018 Uncontrolled When Printed Page 3 of 129 Seized Drugs Training Guide for General Analysis Comparative & Analytical Division Review following sections: Section 4 Material ___________ ____________ Complete Pharmaceutical ID Practice Worksheet ___________ ____________ SOP 3 – Analysis Guidelines for Tablets / Capsules ___________ ____________ SOP 20 – Abbreviations ___________ ____________ SOP 5 – Worksheets ___________ ____________ Review Examination Sheet Documentation for Pharm ID ___________ ____________ 5 – Chemical Spot Tests Independent Reading ___________ ____________ Review following sections: Section 5 Material ___________ ____________ SOP 13 – Chemical Spot Tests ___________ ____________ SOP 12 – Reagent Quality Assurance ___________ ____________ SOP 11 – Drug Standards and Reference Sources ___________ ____________ Prepare Reagent Bottles for Work Area ___________ ____________ Complete and Review Practice Samples for Spot Tests ___________ ____________ Review Examination Sheet Documentation for Spot Tests ___________ ____________ 6 – UV / VIS Spectrophotometry Independent Reading ___________ ____________ Review following sections: Section 6 Material ___________ ____________ SOP 10 – UV/VIS Spectrophotometry (Qualitative only) ___________ ____________ SOP 6 – Instrument Performance and Maintenance (UV) ___________ ____________ Complete and Review Practice Samples for Qualitative UV/VIS ___________ ____________ Complete and Review Practice Samples for Quantitative UV/VIS ___________ ____________ Review Examination Sheet Documentation for UV/VIS ___________ ____________ 7 – Separations and Extractions Independent Reading ___________ ____________ Review Section 7 Material ___________ ____________ Training Guide for General Analysis Document ID: 12013 Issued By: Section Manager Issue Date: June 11, 2018 Uncontrolled When Printed Page 4 of 129 Seized Drugs Training Guide for General Analysis Comparative & Analytical Division Prepare solvents and supplies for extractions in work area ___________ ____________ Complete and Review Practice Samples for Extractions ___________ ____________ Discuss and Practice Conway Extraction ___________ ____________ Review Documentation for Separations and Extractions ___________ ____________ 8 – IR / FTIR Spectroscopy Independent Reading and Training Videos ___________ ____________ Review following sections: Section 8 Material ___________ ____________ SOP 9 – FTIR Spectrometry ___________ ____________ SOP 6 – Instrument Performance and Maintenance (FTIR) ___________ ____________ Complete and Review Practice Samples for FTIR ___________ ____________ Review Examination Sheet Documentation for FTIR ___________ ____________ 9 – Thin Layer Chromatography Independent Reading ___________ ____________ Review following sections: Section 9 Material ___________ ____________ SOP 15 – Thin Layer Chromatography ___________ ____________ Complete Practice Samples for TLC ___________ ____________ Review Examination Sheet Documentation for TLC ___________ ____________ 10 – Gas Chromatography / Mass Spectrometry Independent Reading ___________ ____________ Review following sections: Section 10 Material ___________ ____________ SOP 8 – Gas Chromatography/Mass Spectrometry ___________ ____________ SOP 6 – Instrument Performance and Maintenance (GC/MS) ___________ ____________ Complete and Review Practice Samples for GC/MS ___________ ____________ Review Examination Sheet Documentation for GC/MS ___________ ____________ Training Guide for General Analysis Document ID: 12013 Issued By: Section Manager Issue Date: June 11, 2018 Uncontrolled When Printed Page 5 of 129 Seized Drugs Training Guide for General Analysis Comparative & Analytical Division 11 – Anabolic Steroids Independent Reading ___________ ____________ Review following sections: Section 11 Material ___________ ____________ Complete and Review Practice Samples for Anabolic Steroids ___________ ____________ (include discussion of unique circumstances for all analysis procedures) 12 – Analysis Guidelines Review following sections: Section 12 Material ___________ ____________ SOP 3 – Analysis Guidelines ___________ ____________ SOP 16 – Excess Quantity Cases ___________ ____________ SOP 22 – Re-Analysis of Cases ___________ ____________ SOP 5 – Worksheets ___________ ____________ 13 – Evidence Handling Review following sections: Section 13 Material ____________ ____________ Quality Manual – Handling of Evidence ____________ ____________ SOP 2 – Evidence Handling ____________ ____________ Review Evidence Submission forms ____________ ____________ Review chain of custody transfers and case assignments using LIMS ____________ ____________ 14 – Reporting of Results Review following sections: Section 14 Material ____________ ____________ Quality Manual – Reporting the Results ____________ ____________ SOP 19 – Reporting Guidelines ____________ ____________ Review generating reports using LIMS ____________ ____________ Training Guide for General Analysis Document ID: 12013 Issued By: Section Manager Issue Date: June 11, 2018 Uncontrolled When Printed Page 6 of 129 Seized Drugs Training Guide for General Analysis Comparative & Analytical Division 15 – Case File Documentation Review following sections: Section 15 Material ____________ ____________ Quality Manual – Document Control ____________ ____________