04 Introduction KATIE RAE, CEO & Managing Partner 06 08 Our Mission United Nations Sustainable Development Goals 06 What is Tough Tech? 08 Mapping Portfolio Companies across 07 Our Investment Areas UN SDGs 10 Mapping The Engine Initiatives across UN SDGs 12 66 The Engine Initiatives Portfolio Impact 14 Fostering 68 Climate Change Entrepreneurship 98 Human Health within Science & 122 Advanced Systems & Technology Infrastructure 38 Regional Development Encouraging 50 Commercialization of Tough Tech “ Core to our mission is helping incredible founders, ideas, and companies scale. To create lasting impact for the world, we must reach everyone.” The Engine was spun out of MIT the entrepreneurial community fabrication, and of!ce space for 100 government contract to develop that has taken a tragic human toll in 2016, with the purpose of working across Tough Tech; scaling Tough Tech companies. And we and deploy its network of shoebox- and fundamentally altered the way supporting startups poised to create the diversity of backgrounds, continue to convene thousands of sized satellites to help us better we work and live. The pandemic has a material positive impact on society viewpoints, and approaches to people across the growing Tough understand and protect our world. only served to sharpen our collective and the environment. solving our biggest challenges; Tech community during our annual sense of urgency to discover scaling the jobs added to our region Tough Tech Summit, industry- We’re excited to apply the UN and commercialize Tough Tech We had a bold vision for the impact and the infrastructure that those speci!c Provocations, and other Sustainable Development Goals companies. This report puts the Tough Tech could unlock for the working on the toughest problems gatherings. to our portfolio of Tough Tech scope and scale of Tough Tech into world, but we could never have have access to; and scaling the companies. Inside, you’ll !nd an perspective and serves as a reminder predicted how these years would bene!ts to our community. To I’m both humbled and thrilled outline and analysis of how these of why we must continue to create play out. The past two years in create lasting impact for the world, by the progress of the Tough companies, as well as The Engine the frameworks to support those Katie Rae, particular, which this report will we must reach everyone. Tech companies in our portfolio. itself, !t into the established UN solving massive problems, through CEO & Managing Partner aim to detail, have shown us just Commonwealth Fusion Systems framework. the convergence of science and how widespread and systematic the That is what the past two years have published peer reviewed papers technology. We will continue on our challenges we face are, and why the been about. showing that their approach to The two years since our last report journey to do just that — we hope time to tackle them is now. limitless, net-energy fusion power is have been de!ned by a pandemic that you can join us. We recently launched a program likely to succeed. Biobot Analytics, We do this in a few key ways that called Blueprint, which increases E25Bio, C2Sense, and Vaxess leverage our proximity to the world the pipeline of academic Technologies are each working renowned research institutions researchers and post doctorates towards commercial diagnostic in our backyard: promoting who are ready to take the leap into and therapeutic solutions for “ The pandemic has only served to entrepreneurship within science entrepreneurship. We put forth COVID-19 and other conditions. and technology, commercializing policy recommendations for the Mori showed that its natural coating sharpen our collective sense of urgency Tough Tech, and fostering regional new administration to ensure we can extend the shelf life of fresh to discover and commercialize Tough economic development. are unlocking more innovation fruits, vegetables, and protein by Core to each of those tenets is that will bene!t the world. Our 25%-100%, drastically reducing Tech companies.” helping incredible founders, ideas, 155,000 sq/ft expansion project is food waste and the need for single and companies scale. Scaling well underway and slated to open use packaging. And Analytical the access to opportunities and in late 2022 with laboratories, Space recently received a signi!cant 4 THE ENGINE REPORT !"#$ & !"!" INTRODUCTION 5 Our Investment Areas We look for impact across three general areas that will help the world OUR responsibly adapt to the growth and demands of tomorrow: MISSION Launched by MIT, The Engine that will accelerate progress toward bridges the gap between a healthier population, a more discovery and commercialization accessible and adaptive society, and by empowering disruptive a more resilient world. The Engine CLIMATE CHANGE HUMAN HEALTH ADVANCED SYSTEMS & INFRASTRUCTURE technologies with the capital, rewards con!dence and science with Mitigating, adapting to, Enabling a healthier Adapting and evolving knowledge, network connections, capital and access. and ultimately reversing global population through critical industrial and the specialized equipment and the universal crisis of the advancement of biotech systems that provide the labs they need to thrive. We bridge the gap between climate change, with new and life sciences, by backbone of advanced discovery and commercialization materials and processes developing foundational manufacturing and supply Tough Tech companies have by funding and opening access for to adjust energy sources, technologies to improve chains, the built historically been underserved ambitious Tough Tech founders, reduce carbon emissions, health diagnosis and environment, and space. and underfunded, leaving many making possible the future they and redefine energy treatment and application breakthrough inventions stuck want to see in the world. Our storage. of science-driven inside the lab. This is why we focus community makes impossible processes to ensure food exclusively on founders pioneering progress, achievable and the dif!cult security. technology with the genuine ability challenges, solvable. to transform the planet. Together, we identify and champion Everything we do is in the service of the advanced scienti!c foundation our founders and their work. required to connect, support, power, We focus on supporting the and protect tomorrow’s society and A Relationship founders building technologies environment. of Continued Support Tough Tech is transformative technology that We work closely with founders and + Investment and access to the right capital assets executives to help them scale and + Access to flexible infrastructure solves the world’s most important challenges grow their companies to accelerate + Ongoing connection to the right stakeholders across the path to market. capital, government and strategics through the convergence of breakthrough science, + Support on scaling the organization and finding the engineering, and leadership. right talent + Amplifying their stories and positioning them as leaders in their respective industries 6 THE ENGINE REPORT !"#$ & !"!" OUR MISSION 7 No Poverty Zero Mapping The Engine’s Portfolio across Hunger 01 the United Nations Sustainable Development Goals 02 Good Health & Well-being 03 Quality Education 04 ACHIEVING A BETTER Gender Equalilty AND MORE SUSTAINABLE 05 Clean Water & Sanitation FUTURE FOR ALL 06 The UN Sustainable Development Goals recognize that achieving a better and more A!ordable & Clean Energy sustainable future for all requires an integrated approach to solving a diverse set of issues 07 together. The Engine’s portfolio mirrors this approach and re"ects a broad set of impact areas as a whole. We have mapped the portfolio against these UN SDGs to show how many challenges our Decent Work & 08 Economic Growth companies are working to tackle. For example, companies with a core focus on human health can still have an impact on climate change. This illustrates the ripple effects that will be created as this group continues to hit their impact milestones. That progress will be detailed in the portfolio section of this report. 09 Industry, Innovation, & Infrastructure Boston Metal 10 CLIMATE CHANGE Cambridge Electronics Reduced Inequalities Commonwealth Fusion Systems Form Energy Lilac Solutions Quaise Syzygy Plasmonics Via Separations 11 Biobot Analytics Sustainable Cities HUMAN HEALTH Cellino & Communities E25Bio Kytopen Lucy Therapeutics Mori 12 Seaspire Skincare Responsible Consumption & Production Suono Bio Vaxess Technologies Analytical Space ADVANCED SYSTEMS & C2Sense 13 Celestial.ai INFRASTRUCTURE HyperLight Climate Action ISEE Radix Labs 14 RISE Robotics Sync Computing Life below Water The Routing Company 15 WoHo Zapata Computing 16 Life on Land 17 Peace, Partnerships Justice, & Strong for the Goals Institutions 8 THE ENGINE REPORT !"#$ & !"!" UNITED NATIONS SUSTAINABLE DEVELOPMENT GOALS 9 No Zero Poverty Hunger Mapping The Engine's Mission Driven Initiatives Across the United Nations 01 Good Health & Well-being 02 Sustainable Development Goals 03 Quality Education 04 Gender Equalilty THE ENGINE’S 05 INITIATIVES Clean Water & Sanitation 06 The United Nations Sustainable Development Goals (UN SDGs) were established in 2015 as “a shared blueprint for peace and prosperity for people and the planet, now and into the future.” They have since been adopted by all UN Member States. A!ordable & Clean Energy 07 Throughout the life of our portfolio companies, we work to amplify their mission and help them scale, so