UNIVERSITÉ DE STRASBOURG École Doctorale des Sciences de la Vie et de la Santé IGBMC - CNRS UMR 7104 - Inserm U 964 THÈSE présentée par : Pauline CHARBOGNE soutenue le : 9 juillet 2015 pour obtenir le grade de : Docteur de l’université de Strasbourg en Aspects Moléculaires et Cellulaires de la Biologie Mention Neurosciences Mu opioid receptors and neuronal circuits of addiction: genetic approaches in mice THÈSE dirigée par : Mme KIEFFER Brigitte L. Professeure, Université de Strasbourg/McGill University RAPPORTEURS : M. BELIN David Maître de conférences, University of Cambridge Mme LE MOINE Catherine Directrice de recherche, Université de Bordeaux M. 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