10th Annual Future of Genomic Medicine March 2 - 3, 2017 x Scripps Institution of Oceanography x La Jolla, CA Presented in partnership with Course Introduction Course Overview Course Highlights In collaboration with AAAS/Science Translational Medicine we • Voice of the patient represented throughout invite you to another exciting two day program on Thursday, the conference March 2 and Friday, March 3, 2017 in beautiful San Diego, • Renowned faculty representing the country’s California. The 2017 program will again be held at Scripps leading institutions Institution of Oceanography. • Multiple panel discussion segments with ample question and answer time with faculty The 10th annual Future of Genomic Medicine course will be the • Additional networking opportunities next iteration of taking genomic knowledge to transform the daily practice of medicine. To do this, we have patients present Educational Objectives their story of how genomics affected their medical status, and After attending this activity, participants should be able to: have a faculty of experts in genomics, science and medical • journalism, and the life science industry provide critical Demonstrate the unmet needs of medicine today with respect to more targeted, perspective. This year we will be paying particular attention to individualized prevention and treatments. the exciting area of genomic editing to treat particular diseases, • Discuss the opportunities of the genome, cancer (a disease of the genome), and the genomics of rare proteome, and metabolome discovery to and unknown diseases. Furthermore, we will delve into to the change medical practice as it exists today. hot topics of the microbiome, genomic-guided drug therapies • Assess how changes and advances in and genomic analytics. The overarching goal of the course is to technology are rapidly ushering in a whole spearhead efforts to use genomic knowledge to change medi- array of new pathways for individualized medicine of the future. cine and make it far more precise and individualized. • Explore specific strategies in cancer, idiopathic We look forward to your participation and another successful and pharmacogenomic disease interventions. conference. Target Audience • Physicians • Human geneticists • Genomic scientists • Researchers Eric J. Topol, MD • Health care professionals of all disciplines Course Director interested in the future of medicine, especially with respect to individualized therapies Disclosures and About Scripps Disclosure About Scripps Translational Science Institute Commercial Support The Scripps Translational Science Institute (STSI) aims to replace the This course is supported, in part, by educational status-quo of one-size-fits-all-medicine with individualized health grants from industry. At the time of printing, a care that is based on the known genetic factors influencing health and complete listing of commercial supporters was disease and that takes advantage of advances in digital technology not available. Appropriate acknowledgement for real-time health monitoring. will be given to all supporters at the time of Since its founding in 2006 by Scripps Health, STSI has been the educational activity. distinguished by its leadership in translational genomics and Cultural and Linguistic Competency for harnessing digital, or wireless, medical technology for health This activity is in compliance with California monitoring of individual patients. In addition, it is the only member Assembly Bill 1195 which requires that all CME of the National Institutes of Health’s Clinical and Translational Science activities comprising a patient care element Award (CTSA) consortium that is not affiliated with a university. include curriculum addressing the topic of STSI hybridizes The Scripps Research Institute (TSRI) ‘s considerable cultural and linguistic competency. The intent biomedical science expertise with Scripps Health’s exceptional patient of this bill is to ensure that health care pro- care and clinical research. As a translational bridge between TSRI and fessionals are able to meet the cultural and Scripps Health, STSI fosters innovative programs and methodology, linguistic concerns of a diverse patient popu- provides an optimal setting for training and education and accelerates lation through effective and appropriate pro- the conduct of studies that will have the greatest potential impact on fessional development. Cultural and linguistic the practice of health care in the clinic and the community. competency was incorporated into the plan- For more information on Scripps Translational Science Institute, visit ning of this activity. www.stsiweb.org. Faculty Course Director Faculty Eric J. Topol, MD Jehannine Austin, PhD, CGC Daniel MacArthur, PhD Founder & Director Associate Professor and Genetic Counselor Assistant Professor Scripps Translational Science Institute Departments of Psychiatry and Massachusetts General Hospital Chief Academic Officer, Scripps Health Medical Genetics Co-Director of Medical and Population Genetics Professor of Genomics The University of British Colombia The Broad Institute of MIT and Harvard The Scripps Research Institute Ed Boyden, PhD Siddhartha Mukherjee, MD Associate Professor Assistant Professor of Medicine Planning Committee Media Lab and McGovern Institute Columbia University Massachusetts Institute of Technology Physician, Columbia University Medical Center Kristian G. Andersen, PhD Author, The Gene: An Intimate History Atul Butte, MD, PhD Director, Infectious Disease Genomics Director and Distinguished Professor Eric M. Reiman, MD Scripps Translational Science Institute Institute for Computational Health Sciences Executive Director Assistant Professor Executive Director for Clinical Informatics Banner Alzheimer’s Institute (BAI) The Scripps Research Institute University of California, San Francisco Chief Executive Officer, Banner Research Laura Nicholson, MD, PhD Clinical Director, Neurogenomics Eric Dishman, MD, PhD Co-Director, Education Translational Genomics Research Institute (TGen) Director Scripps Translational Science Institute Professor of Psychiatry, University of Arizona Precision Medicine Initiative (PMI) Associate Program Director Director, Arizona Alzheimer’s Consortium National Institutes of Health Medicine Residency, Scripps Health Pardis C. Sabeti, MD, DPhil Brian J. Druker, MD Professor, Center for Systems Biology Emily Spencer, PhD Director, Knight Cancer Institute Professor, Department of Organismic Director, Clinical Genomics Program Oregon Health & Science University and Evolutionary Biology Assistant Professor JELD-WEN Chair of Leukemia Research Faculty, Center for the Scripps Translational Science Institute Investigator, Howard Hughes Medical Institute Communicable Disease Dynamics Steven R. Steinhubl, MD Michael B. Eisen, PhD Harvard University Director, Digital Medicine Investigator, Howard Hughes Medical Institute Eric Schadt, PhD Scripps Translational Science Institute Professor of Genetics Professor and Chair Associate Professor of Genomic Medicine Genomics and Development Genetics and Genomic Sciences The Scripps Research Institute University of California, Berkeley Director, Icahn Institute for Genomics Andrew Su, PhD Laura J. Esserman, MD, MBA and Multiscale Biology Director, Bioinformatics Professor, Department of Surgery and Radiology Jay Shendure, MD, PhD Scripps Translational Science Institute Director, Carol Franc Buck Breast Care Center Professor of Genome Sciences Associate Professor Co-Leader, Breast Oncology Program University of Washington The Scripps Research Institute University of California, San Francisco School of Medicine Ali Torkamani, PhD Jeff Huber Ramji Srinivasan Director, Genome Informatics and Drug Discovery Chief Executive Officer Chief Executive Officer Scripps Translational Science Institute GRAIL Assistant Professor, Molecular and Experimental Counsyl Sekar Kathiresan, MD Medicine, The Scripps Research Institute Beth Stevens, PhD Cardiologist, Human Geneticist Institute Member, The Broad Institute Nathan E. Wineinger, PhD Director, Preventive Cardiology of MIT and Harvard Director, Biostatistics Massachusetts General Hospital Assistant Professor, Harvard Medical School Assistant Professor Associate Member, Program of Medical Research Associate Scripps Translational Science Institute and Population Genetics Neurobiology at Boston Children’s Hospital Associate Professor of Medicine Harvard School of Medicine Ed Yong Science Writer Paul Knoepfler, PhD The Atlantic Professor Department of Cell Biology and Feng Zhang, PhD Human Anatomy Core Institute Member University of California, Davis The Broad Institute of MIT and Harvard Investigator, The McGovern Institute, MIT Razelle Kurzrock, MD Associate Professor, Department of Chief, Division of Hematology and Oncology Brain and Cognitive Sciences, MIT UCSD School of Medicine Associate Professor, Department of Senior Deputy Director, Clinical Science Biological Engineering, MIT Director, Center for Personalized Cancer Therapy Robertson Investigator Director, Clinical Trials Office New York Stem Cell Foundation UCSD Moores Cancer Center Carl Zimmer Erez S. Lieberman Aiden, PhD Columnist Assistant Professor The New York Times Molecular and Human Genetics Contributing National Correspondent Assistant Professor, Computer Science STAT Assistant Professor Computational and Applied Mathematics Baylor College of Medicine Bill Lundberg, MD Chief Scientific Officer CRISPR Therapeutics Agenda Thursday, March 2, 2017 12:30 p.m. Brian Druker/Cancer 7:30