Bone Abstracts June 2017 Volume 6 ISSN 2052-1219 (online) 8th International Conference on Children's Bone Health 10–13 June 2017, Würzburg, Germany published by Online version available at bioscientifica www.bone-abstracts.org Volume 6 Bone Abstracts June 2017 8th International Conference on Children’s Bone health 10–13 June 2017, Wu¨rzburg, Germany Abstract book ORGANISERS ICCBH Steering Group Maria Luisa Bianchi (Milan, Italy) Craig B Langman (Chicago, USA) Nick Bishop (Sheffield, UK) Coen Netelenbos (Amsterdam, Netherlands) Christine Hofmann (Wu¨rzburg, Germany) Leanne Ward (Ottawa, Canada) Wolfgang Ho¨gler (Birmingham, UK) Programme Organising Committee Christine Hofmann (Wu¨rzburg, Germany) (Chair) Mairead Kiely (Cork, Ireland) Maria Luisa Bianchi (Milan, Italy) Klaus Klaushofer (Vienna, Austria) Nick Bishop (Sheffield, UK) Craig B Langman (Chicago, USA) Alison Boyce (Washington DC, USA) David Little (Sydney, Australia) Nicola Crabtree (Birmingham, UK) Outi Ma¨kitie (Helsinki, Finland) Hermann Girschick (Berlin, Germany) Craig Munns (Sydney, Australia) Wolfgang Ho¨gler (Birmingham, UK) Coen Netelenbos (Amsterdam, Netherlands) Franz Jakob (Wu¨rzburg, Germany) Keiichi Ozono (Osaka, Japan) Local Organising Committee Christine Hofmann (Wu¨rzburg, Germany) (Chair) Klaus Klaushofer (Vienna, Austria) Suzanne Bechtold-Dalla Pozza (Munich, Germany) Marius Kraenzlin (Basel, Switzerland) Hermann Girschick (Berlin, Germany) Christof Land (Munich, Germany) Gabriele Ha¨usler (Vienna, Austria) Barbara Obermayer-Pietsch (Graz, Austria) Franz Jakob (Wu¨rzburg, Germany) Elisabeth Steichen-Gersdorf (Innsbruck, Austria) ICCBH Web address: www.iccbh.org ICCBH 2017 SPONSORS AND OTHER SUPPORTERS We are extremely grateful to the following organisations for their support. Premium Sponsor Alexion Pharma Platinum Sponsor Kyowa Kirin Gold Sponsor Clementia Silver Sponsors Mereo Sandoz Bronze Sponsor Amgen Exhibitors Merck Serono Stratec Medizintechnik/Novotec Medical Other Supporters Eli Lilly European Calcified Tissue Society Ferring Novo Nordisk UCB Endorsed by International Osteoporosis Foundation (IOF) The Scientific Programme has been developed independently by the Programme Organising Committee under no influence from any supporting organisation or their employees. Meeting organisation Janet Crompton Conference Organiser Tel: +44 (0)1453 549929 Email: [email protected] Local Agent: Ralph Kerschbaumer S12! studio 12 gmbh Tel: +43 (0) 512 890438 Email: [email protected] Bone Abstracts (2017) Vol 6 ICCBH 2017 AWARDS New Investigator Awards Fawaz Alqahtani (Sheffield, UK), P079 Nadia Amin (Leeds, UK), P182 Giulia Battafarano (Rome, Italy), P039 Vickie Braithwaite (Cambridge, UK), OC7 Neil Brett (Montreal, Canada), OC6 Ka-Yee Cheuk (Shatin, Hong Kong), P141 Alice Costantini (Stockholm, Sweden), P114 Olja Grgic (Rotterdam, The Netherlands), OC15 Elisa Holmlund-Suila (Helsinki, Finland), P027 Aijaz Ahmad John (Lucknow, India), P125 Antonio Maurizi (L’Aquila, Italy), P189 Carolina Medina-Gomez (Rotterdam, The Netherlands), P015 Rebecca Moon (Southampton, UK), OC4 Carol nı´ Chaoimh (Cork, Ireland), P161 Gareth Penman (Sheffield, UK), P054 Mary Scott Ramnitz (Bethesda, USA), OC20 Maria Rønne (Odense, Denmark), P004 Michela Rossi (Rome, Italy), P034 Taryn Smith (Guildford, UK), OC10 Sonja Soininen (Kuopio, Finland), OC14 Enrica Urciuoli (Rome, Italy), P202 Dimitris Vlachopoulos (Exeter, UK), P013 Marius Vogt (Wu¨rzburg, Germany), OC16 Best Oral Communication Award Mary Scott Ramnitz (Bethesda, USA), OC20 Best Poster Awards Stephanie Graser (Wu¨rzburg, Germany), P057 Antonio Maurizi (L’Aquila, Italy), P189 Michela Rossi (Rome, Italy), P034 Slemenda Award The 2017 Charles Slemenda Award was awarded to Frank Rauch (Montreal, Canada) in recognition of his outstanding contribution to children’s bone research. Previous winners: 2015 Zulf Mughal (Manchester, UK) 2013 Maria Luisa Bianchi (Milan, Italy) 2009 Michael Whyte (St Louis, USA) 2007 Ailsa Goulding (Dunedin, New Zealand) 2005 Jean-Philippe Bonjour (Switzerland, Geneva) 2002 John Pettifor (Johannesburg, South Africa) 1999 Francis Glorieux (Montreal, Canada) Bone Abstracts (2017) Vol 6 ICCBH 2017 CONTENTS ICCBH 2017 10–13 June 2017 INVITED SPEAKER ABSTRACTS .......................................... IS01–IS22 ORAL COMMUNICATIONS .............................................. OC1–OC26 POSTER PRESENTATIONS ............................................. P001–P209 LATE BREAKING ORAL COMMUNICATION ABSTRACTS . LB1–LB21 INDEX OF AUTHORS Bone Abstracts (2017) Vol 6 ICCBH 2017 Invited Speaker Abstracts and Biographical Notes Bone Abstracts (2017) Vol 6 ICCBH 2017 IS01 IS01 Roland Baron Biographical details Dr Roland Baron Dr Roland Baron is Professor of Medicine at the Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Professor in the Division of Bone and Mineral Research and Chair of the Department of Oral Medicine, Infection and Immunity at the Harvard School of Dental Medicine since January 2008. From 1977 - 2007 Dr Roland Baron was a Professor in the departments of Medicine, Orthopedics and Cell Biology at Yale University School of Medicine. He received his DDS and PhD degrees from the Medical School, University of Paris, France. He is the founder and past Editor-in-Chief of BONE. Between 1994 and 2002, he also held the position of Vice President and Head of the Bone Diseases Group at Hoechst Marion Rousse and then at Aventis. In 2002 he founded ProSkelia, a small pharmaceutical company devoted to the discovery and development of new drugs for bone and hormonal dependent diseases, now part of Galapagos. He has held the positions of President and Chief Scientific Officer of ProSkelia and then ProStrakan, until April 2006. Dr Baron was the President of ECTS 2008-11 and the President of the American Society for Bone and Mineral Research (ASBMR) in 2014-15. Dr Baron received the William Neumann Award and the Avioli Founder Award from ASBMR, the Harold Copp Award from the International Bone and Mineral Society (IBMS), the Excellence in Research Award from the European Calcified Tissue Society (ECTS) and has published over 330 scientific papers in the field of bone biology, bone diseases and their treatment. He is currently the co-Chair of the International Federation of Musculoskeletal Research Societies. DOI: 10.1530/boneabs.6.IS01 Bone Abstracts (2017) Vol 6 ICCBH 2017 IS02 Highlights in clinical bone research Frank Rauch Shriners Hospital for Children and McGill University, Montreal, Canada Pediatric bone health research is rapidly expanding. As many bone disorders in children are rare, the field benefits from the attention that rare disorders in general are currently receiving. Consequently, new approaches for treating bone diseases in children have been developed and are being studied in clinical trials. The treatment of hypophosphatasia with bone-targeted enzyme replacement therapy is one of the most advanced programs in this area. New studies on this approach show that it improves survival for perinatal and infantile hypophosphatasia and that school children with hypophosphatasia benefit from enzyme replacement long term. Novel genetic causes of rare pediatric bone diseases are being discovered, even though the large majority of patients with well-defined bone fragility phenotypes have mutations in known genes. New insights are also being generated on more traditional topics of the pediatric bone health field, such as vitamin D supplementation in infancy, where well-designed randomized trials have shown lasting benefits on bone mass and body composition. The pediatric bone health field greatly benefits from long-term studies on large cohorts. One study on healthy children investigated muscle-bone interactions and found that gross-motor skills at 18 months of age are related to measures of bone strength at the age of 17 years. Thus, considerable advances are being made in a wide range of pediatric bone health areas. Disclosure Receipt of grants/research support from Ultragenyx and Alexion. DOI: 10.1530/boneabs.6.IS02 Biographical details Frank Rauch Frank Rauch, MD, is a Professor of Pediatrics and clinician-scientist at the Shriners Hospital for Children and at McGill University. His clinical activities and research program concentrate on improving bone health in children, with a special focus on genetic conditions leading to fractures and on the role of the muscle system in bone diseases. In his recent work, Dr Rauch has identified new genetic causes of brittle bone disorders and has assessed the long-term effects of bisphosphonate treatment in children with osteogenesis imperfecta. He is also collaborating with Statistics Canada in a study that assesses muscle and bone health in Canadians. Dr Rauch is currently serving as Editor- in-Chief of the Journal of Musculoskeletal and Neuronal Interactions. Dr Rauch has authored or co-authored more than 200 original publications. Bone Abstracts (2017) Vol 6 ICCBH 2017 IS03 Bone cells in health and disease Roberta Besio, Roberta Gioia, Francesca Tonelli, Ilaria Ceppi, Laura Leoni, Linda Ofori Atta, Antonio Rossi & Antonella Forlino Department of Molecular Medicine, University of Pavia, Pavia, Italy Bone is a complex tissue constituted by a mineral phase, hydroxyapatite, and an organic phase, mainly represented by collagen type I. Specialized cells are responsible for bone formation and remodeling. Osteoblasts represent the bone forming cells, osteocyte are the orchestrator of bone remodeling through regulation of the other bone cells activity,