2015-2016 COM ANNUAL REPORT COM ANNUAL 2015-2016 UNIVERSITY OF SOUTH ALABAMA ANNUAL REPORT UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE COLLEGE OF MEDICINE October 1, 2015 – September 30, 2016 ANNUAL REPORT UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE October 1, 2015 through September 30, 2016 TABLE OF CONTENTS Page I. Reports from Departments and Centers Biochemistry and Molecular Biology .........................................................................1 Comparative Medicine ................................................................................................5 Emergency Medicine ...................................................................................................7 Family Medicine .........................................................................................................14 Internal Medicine .......................................................................................................16 Microbiology and Immunology ................................................................................28 Neurology ....................................................................................................................34 Neurosurgery ..............................................................................................................39 Obstetrics and Gynecology........................................................................................41 Orthopaedic Surgery .................................................................................................50 Pathology ....................................................................................................................55 Pediatrics ....................................................................................................................59 Pharmacology .............................................................................................................72 Physiology and Cell Biology ......................................................................................81 Psychiatry ...................................................................................................................87 Radiology ....................................................................................................................96 Surgery ......................................................................................................................100 Biomedical Library ..................................................................................................112 Center for Lung Biology ..........................................................................................117 Center for Healthy Communities ...........................................................................120 Center for Strategic Health Innovation .................................................................123 Center for Disaster Preparedness...........................................................................126 Comprehensive Sickle Cell Center .........................................................................129 II. Report from Office of Development and Alumni Relations .......................................133 III. Report from Division of Medical Education and Student Affairs .............................136 IV. Report from Admissions................................................................................................154 V. Report from Continuing Medical Education ..............................................................157 VI. Report from Graduate Medical Education .................................................................158 VII. Report from Medical Student Summer Research Program ......................................164 VIII. Report from the Graduate Program in Basic Medical Sciences ................................169 IX. Summary of Extramural Support ................................................................................173 FOREWORD This Annual Report of the College of Medicine catalogues recent accomplishments of our faculty, students, residents, fellows and staff in teaching, research, patient care, scholarly and community service activities during the 2015-16 academic year. Our 2016 graduating class, the first group of students experiencing the revised four year curriculum performed above the national average on National Board Step 1 and Step 2 exams and received excellent residency positions in a variety of clinical disciplines. Several key leadership changes occurred during the year including the culmination of a national search for a new dean and vice president for medical affairs. Dr. John V. Marymont assumed the dual title on July 1, 2016 having served previously as chair of the department of orthopaedics and interim dean at LSU Shreveport School of Medicine. Changes in leadership within the USA Health System included the retirement of Mr. Stanley Hammack as vice president and the appointments of Mr. Owen Bailey as chief operating officer and Dr. Alan Whaley as chief strategy officer for USA Health. A major initiative began in preparation for the implementation of a comprehensive, integrated health information system known as Unity. Effective collaboration of all administrative units, the new information platform and the entire USA health system is key to avoid compromising the educational and other important missions of the College of Medicine. Finally, I regret to acknowledge that several former members of the college’s leadership team died during this year: Drs. Jeffrey C. Brandon, Robert A. Kreisberg, Angus McBryde, Jr., John Shackleford, Aubrey E. Taylor, and J. Allan Tucker, Jr. This issue of the Annual Report is dedicated in their memory and in appreciation for their dedication, commitment and contributions. Samuel J. Strada, Ph.D. Dean Emeritus USA College of Medicine 2015-2016 Summary of Scholarly Activities Department of Biochemistry & Molecular Biology I. PUBLISHED JOURNAL ARTICLES, BOOK CHAPTERS, AND PATENTS Chattopadhyay D, Swingle MR, Salter EA, Wood E, D’Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, Yet L, Schroeder CE, Golden JE, Dunham WH, Gingras AC, Banerjee S, Forbes D, Wierzbicki A, Honkanen RE. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem Pharmacol. 2016 Jun 1;109:14-26. Kim JH, Baddoo MC, Park EY, Stone JK, Park H, Butler TW, Huang G, Yan X, Pauli- Behn F, Myers RM, Tan M, Flemington EK, Lim ST, Ahn EY. SON and its alternatively spliced isoforms control MLL complex-mediated H3K4me3 and transcription of leukemia-associated genes. Mol Cell. 2016 Mar 17;61(6):859-73. Kim JH, Shinde DN, Reijnders MR, Hauser NS, Belmonte RL, Wilson GR, Bosch DG, Bubulya PA, Shashi V, Petrovski S, Stone JK, Park EY, Veltman JA, Sinnema M, Stumpel CT, Draaisma JM, Nicolai J, University of Washington Center for Mendelian Genomics, Yntema HG, Lindstrom K, de Vries BB, Jewett T, Santoro SL, Vogt J, Deciphering Developmental Disorders Study, Bachman KK, Seely AH, Krokosky A, Turner C, Rohena L, Hempel M, Kortum F, Lessel D, Neu A, Strom TM, Wieczorek D, Bramswig N, Laccone FA, Behunova J, Rehder H, Gordon CT, Rio M, Romana S, Tang S, El-Khechen D, Cho MT, McWalter K, Douglas G, Baskin B, Begtrup A, Funari T, Schoch K, Stegmann AP, Stevens SJ, Zhang DE, Traver D, Yao X, MacArthur DG, Brunner HG, Mancini GM, Myers RM, Owen LB, Lim ST, Stachura DL, Vissers LE, Ahn EY. De novo mutations in SON disrupt RNA splicing of genes essential for brain development and metabolism, causing an intellectual-disability syndrome. Am J Hum Genet. 2016 Sep 1;99(3):711-9. LeClaire LL, Fortwendel JR. Differential support of Aspergillus fumigatus morphogenesis by yeast and human actins. PLoS One. 2015 Nov 10;10(11):e0142535. Lim S, Smith KR, Lim ST, Tian R, Lu J, Tan M. Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation. Cell Biosci. 2016 Apr 14;6:25 Morrow KA, Ochoa CD, Balczon R, Zhou C, Cauthen L, Alexeyev M, Schmalzer KM, Frank DW, Stevens T. Pseudomonas aeruginosa exoenzymes U and Y induce a transmissible endothelial proteinopathy. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L337-53. Murphy JM, Park H, Lim ST. FAK and Pyk2 in disease. Front Biol. 2016 Feb;11(1):1-9. 1 II. PUBLISHED ABSTRACTS Balczon RD, Morrow A, Zhou C, Alexeyev M, Frank D, Stevens T. Activation of prion protein protects pulmonary endothelial cells from the effects of cytotoxin produced during Pseudomonas aeruginosa infection. Mol Biol Cell. 2015 Dec 15;26(25):P2399. Comer BS, Halayko AJ, Gerthoffer WT. MicroRNA-155 targets tristetraprolin and enhances cytokine expression in airway smooth muscle. Am J Respir Crit Care Med. 2016;193:A2464. Available from: http://www.atsjournals.org/doi/pdf/10.1164/ajrccm- conference.2016.193.1_MeetingAbstracts.A2464 Hamilton CL, Kadeba PI, Abney KA, Honkanen RE, Scammell JG, Cioffi DL. The role of PP5 in the FKB51 inhibition of Isoc current. FASEB J. 2016;30:980.6. Kim JH, Park EY, Stone JK, Butler TW, Lim S, Ahn EYE. SON and its splice variants regulate MLL ½ complex-mediated H3K4me3 and transcription of leukemia-associated genes. American Association for Cancer Research Annual Meeting 2016; 2016 Apr 16- 20; New Orleans, LA. Abstract no. 1978. LeClaire LL, Fortwendel JR. Pharmacological stabilization of filamentous actin in Aspergillus fumigatus prevents conidial germination and alters hyphal morphology. Mol Biol Cell. 2015 Dec 15;26(25)P881.