Accepted Manuscript Precuneus-related regional and network functional deficits in social anxiety disorder: a resting-state functional MRI study Cui Yuan, Hongru Zhu, Zhengjia Ren, Minlan Yuan, Meng Gao, Yan Zhang, Yuchen Li, Yajing Meng, Qiyong Gong, Su Lui, Changjian Qiu, Wei Zhang PII: S0010-440X(17)30264-X DOI: https://doi.org/10.1016/j.comppsych.2017.12.002 Reference: YCOMP 51925 To appear in: Please cite this article as: Cui Yuan, Hongru Zhu, Zhengjia Ren, Minlan Yuan, Meng Gao, Yan Zhang, Yuchen Li, Yajing Meng, Qiyong Gong, Su Lui, Changjian Qiu, Wei Zhang , Precuneus-related regional and network functional deficits in social anxiety disorder: a resting-state functional MRI study. The address for the corresponding author was captured as affiliation for all authors. Please check if appropriate. Ycomp(2017), https://doi.org/ 10.1016/j.comppsych.2017.12.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ACCEPTED MANUSCRIPT Precuneus-related regional and network functional deficits in social anxiety disorder: a resting-state functional MRI study Cui Yuana,1, Hongru Zhua,b,1, Zhengjia Rena,c, Minlan Yuana, Meng Gaoa, Yan Zhanga, Yuchen Lia, Yajing, Menga, Qiyong Gongd, Su Luid, Changjian Qiua, Wei Zhanga* Abstract Background: Neuroimaging findings suggest that social anxiety disorder (SAD) may be correlated with changes in regional- or network-level brain function. However, few studies have explored alterations in intrinsic resting cerebral function in patients with SAD at both the regional and network levels, particularly focusing on the theory of mind (ToM)-related regions. This study was performed to investigate changes in neural activity and functional connectivity (FC) in ToM-related regions during the resting state in SAD patients and to determine how these alterations are correlated with the clinical symptoms of SAD. Methods: Forty-three SAD patients and 43 matched healthy controls underwent a Mental HealthACCEPTED Center, West China Hospital MANUSCRIPT of Sichuan University, Chengdu 610041, China b State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China c Southwest Hospital, Third Military Medical University, Chongqing 400038, China. d Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China 1 Cui Yuan and Hongru Zhu contributed equally to this study. *Correspondence to: W. Zhang, Mental Health Center, West China Hospital of Sichuan University, Chengdu 610041, China. Tel.: +86 28 85422005. [在此处键入] .