Supplementary material Gut Supplementary Table 8 Spearman's correlations between targeted urinary urolithins and microbiota. Urolithin- Urolithin- Urolithin- Total A- B- C- Urolithins Family level Taxonomy glucuronid glucuronid glucuronid (A+B+C) e e e Actinobacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium adolescentis_msp_0263 -0.18 -0.09 -0.16 -0.18 Bifidobacteriaceae Bifidobacterium; Bifidobacterium adolescentis Actinobacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium bifidum_msp_0419 -0.12 -0.2 -0.08 -0.13 Bifidobacteriaceae Bifidobacterium; Bifidobacterium bifidum Actinobacteria; Coriobacteriia; Coriobacteriales; Coriobacteriaceae; Collinsella; Collinsella aerofaciens_msp_1244 -0.15 -0.06 -0.04 -0.18 Coriobacteriaceae Collinsella aerofaciens Actinobacteria; Coriobacteriia; Eggerthellales; Eggerthellaceae; Adlercreutzia; unclassified Adlercreutzia_msp_0396 0.09 0.01 0.16 0.12 Eggerthellaceae unclassified Adlercreutzia Actinobacteria; Coriobacteriia; Eggerthellales; Eggerthellaceae; Eggerthella; Eggerthella lenta_msp_0573 0.03 -0.15 0.08 0.03 Eggerthellaceae Eggerthella lenta Actinobacteria; Coriobacteriia; Eggerthellales; Eggerthellaceae; Gordonibacter; Gordonibacter urolithinfaciens_msp_1339 0.19 -0.05 0.18 0.19 Eggerthellaceae Gordonibacter urolithinfaciens Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides cellulosilyticus_msp_0003 0.12 0.11 0.15 0.15 Bacteroidaceae Bacteroides cellulosilyticus Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides dorei_msp_0035 0.12 0.23 0.14 0.19 Bacteroidaceae Bacteroides dorei Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides faecis_msp_0019 0.09 -0.11 0.15 0.07 Bacteroidaceae Bacteroides faecis Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides salyersiae_msp_0037 0.17 0.11 0.05 0.17 Bacteroidaceae Bacteroides salyersiae Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides sp. CAG:144_msp_0412 0.2 0.26 0.15 0.24 Bacteroidaceae Bacteroides sp. CAG:144 Coprobacter secundus == Gabonia Bacteroidetes; Bacteroidia; Bacteroidales; Barnesiellaceae; Coprobacter; 0.2 0.13 0.14 0.2 Barnesiellaceae massiliensis_msp_0198 Coprobacter secundus == Gabonia massiliensis Alistipes inops == Tidjanibacter Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes 0.05 -0.17 0 -0.02 Rikenellaceae massiliensis_msp_0230 inops == Tidjanibacter massiliensis Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes Alistipes obesi_msp_0225 0.1 0.23 0.08 0.16 Rikenellaceae obesi Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes Alistipes senegalensis_msp_0381 0.11 0.16 0.02 0.11 Rikenellaceae senegalensis Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides; Parabacteroides goldsteinii_msp_0028 0.2 0.06 0.14 0.17 Tannerellaceae Parabacteroides goldsteinii Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides; Parabacteroides merdae_msp_0027 -0.02 -0.15 -0.05 -0.09 Tannerellaceae Parabacteroides merdae Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Streptococcus thermophilus_msp_0833 -0.16 -0.06 -0.23 -0.16 Streptococcaceae Streptococcus thermophilus Butyricicoccus sp. 2789STDY5834927 / Clostridia Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Butyricicoccus; -0.06 -0.17 -0.03 -0.05 Clostridiaceae bacterium UC5.1-1D1_msp_1381 Butyricicoccus sp. 2789STDY5834927 / Clostridia bacterium UC5.1-1D1 Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium Clostridium saudiense_msp_0362 -0.15 -0.17 -0.07 -0.17 Clostridiaceae saudiense Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium Clostridium sp. 2789STDY5608831_msp_1608c -0.11 0.16 -0.03 -0.02 Clostridiaceae sp. 2789STDY5608831 Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium Clostridium sp. AT4_msp_0066 -0.14 -0.14 -0.14 -0.17 Clostridiaceae sp. AT4 Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; unclassified unclassified Clostridium_msp_0563 0.19 -0.02 0.12 0.13 Clostridiaceae Clostridium Firmicutes; Clostridia; Clostridiales; Eubacteriaceae; Eubacterium; Eubacterium Eubacterium eligens_msp_0029 0.18 0.2 0.25 0.26 Eubacteriaceae eligens Meslier V, et al. Gut 2020; 69:1258–1268. doi: 10.1136/gutjnl-2019-320438 Supplementary material Gut Firmicutes; Clostridia; Clostridiales; Eubacteriaceae; Eubacterium; Eubacterium Eubacterium sp. 36_13 & CAG:86_msp_0227 0.19 0.14 0.24 0.24 Eubacteriaceae sp. 36_13 & CAG:86 Firmicutes; Clostridia; Clostridiales; Eubacteriaceae; Eubacterium; Eubacterium Eubacterium sp. CAG:115_msp_0047 0.21 0.06 0.16 0.22 Eubacteriaceae sp. CAG:115 Firmicutes; Clostridia; Clostridiales; Eubacteriaceae; Eubacterium; Eubacterium Eubacterium sp. CAG:180_msp_0271 -0.19 -0.05 -0.13 -0.18 Eubacteriaceae sp. CAG:180 Firmicutes; Clostridia; Clostridiales; Eubacteriaceae; Eubacterium; Eubacterium Eubacterium sp. CAG:248_msp_0161 -0.02 -0.01 -0.15 -0.05 Eubacteriaceae sp. CAG:248 Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Blautia Blautia massiliensis_msp_0141 -0.18 -0.2 -0.13 -0.21 Lachnospiraceae massiliensis Blautia obeum_msp_0436 0.02 0.15 0.04 0.06 Lachnospiraceae Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Blautia obeum Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Blautia sp. Blautia sp. CAG:237_msp_0189 0.21 -0.03 0.19 0.19 Lachnospiraceae CAG:237 Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Blautia sp. Blautia sp. CAG:257_msp_0052 -0.19 -0.15 -0.15 -0.24 Lachnospiraceae CAG:257 Blautia sp. Marseille-P3087 / Ruminococcus sp. Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Blautia sp. -0.16 -0.08 -0.01 -0.14 Lachnospiraceae 2789STDY5608882_msp_0722 Marseille-P3087 / Ruminococcus sp. 2789STDY5608882 Blautia wexlerae_msp_0076 -0.17 -0.25 -0.1 -0.21 Lachnospiraceae Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Blautia wexlerae Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Ruminococcus Ruminococcus gnavus_msp_0058 -0.2 -0.21 -0.24 -0.26 Lachnospiraceae gnavus Ruminococcus sp. CAG:60 / Blautia sp. Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Ruminococcus 0.23 0.09 0.15 0.19 Lachnospiraceae 2789STDY5608836_msp_0244 sp. CAG:60 / Blautia sp. 2789STDY5608836 Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Ruminococcus Ruminococcus torques_msp_0126 -0.13 -0.17 -0.15 -0.15 Lachnospiraceae torques Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; unclassified unclassified Blautia_msp_0756 0.14 0.23 0.15 0.16 Lachnospiraceae Blautia Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; unclassified unclassified Blautia_msp_1385 0 0.15 -0.04 0.04 Lachnospiraceae Blautia Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Coprococcus; Coprococcus catus_msp_0986 -0.01 0.01 0.19 0 Lachnospiraceae Coprococcus catus Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Coprococcus; Coprococcus comes_msp_0259 -0.2 -0.03 -0.12 -0.15 Lachnospiraceae Coprococcus comes Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Coprococcus; Coprococcus eutactus 2_msp_0042 0.13 0.16 0.03 0.14 Lachnospiraceae Coprococcus eutactus 2 Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Dorea; Dorea Dorea formicigenerans_msp_0506 -0.22 -0.15 -0.04 -0.22 Lachnospiraceae formicigenerans Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Dorea; Dorea Dorea longicatena 1_msp_0307 -0.24 -0.03 -0.06 -0.19 Lachnospiraceae longicatena 1 Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Eisenbergiella; Eisenbergiella tayi_msp_0014 -0.2 -0.09 0 -0.16 Lachnospiraceae Eisenbergiella tayi Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnoclostridium; Clostridium asparagiforme == lavalense_msp_0360 0.09 -0.24 0.04 0.04 Lachnospiraceae Clostridium asparagiforme == lavalense Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnoclostridium; Clostridium bolteae_msp_0009 -0.04 -0.26 -0.02 -0.07 Lachnospiraceae Clostridium bolteae Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnoclostridium; Clostridium clostridioforme 1_msp_0020 -0.09 -0.09 -0.15 -0.08 Lachnospiraceae Clostridium clostridioforme 1 Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnoclostridium; Clostridium glycyrrhizinilyticum_msp_0510 -0.16 -0.14 -0.12 -0.2 Lachnospiraceae Clostridium glycyrrhizinilyticum Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnoclostridium; Clostridium symbiosum_msp_0086 -0.01 -0.17 -0.08 -0.05 Lachnospiraceae Clostridium symbiosum Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnoclostridium; unclassified Lachnoclostridium_msp_0049 0.22 -0.06 0.03 0.18 Lachnospiraceae unclassified Lachnoclostridium Meslier V, et al. Gut 2020; 69:1258–1268. doi: 10.1136/gutjnl-2019-320438 Supplementary material Gut Lachnospira sp. 2789STDY5834967 / Clostridiales Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospira; bacterium KLE1615 & 0.15 0.09 0.23 0.19 Lachnospiraceae Lachnospira sp. 2789STDY5834967 / Clostridiales bacterium KLE1615 & 41_12_two_minus_msp_0572 41_12_two_minus Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia; Roseburia Roseburia faecis_msp_0015 0.15 -0.03 0.11 0.17 Lachnospiraceae faecis Firmicutes; Clostridia; Clostridiales;