PDF Output of CLIC (Clustering by Inferred Co-Expression)

PDF Output of CLIC (Clustering by Inferred Co-Expression)

PDF Output of CLIC (clustering by inferred co-expression) Dataset: Num of genes in input gene set: 15 Total number of genes: 16493 CLIC PDF output has three sections: 1) Overview of Co-Expression Modules (CEMs) Heatmap shows pairwise correlations between all genes in the input query gene set. Red lines shows the partition of input genes into CEMs, ordered by CEM strength. Each row shows one gene, and the brightness of squares indicates its correlations with other genes. Gene symbols are shown at left side and on the top of the heatmap. 2) Details of each CEM and its expansion CEM+ Top panel shows the posterior selection probability (dataset weights) for top GEO series datasets. Bottom panel shows the CEM genes (blue rows) as well as expanded CEM+ genes (green rows). Each column is one GEO series dataset, sorted by their posterior probability of being selected. The brightness of squares indicates the gene's correlations with CEM genes in the corresponding dataset. CEM+ includes genes that co-express with CEM genes in high-weight datasets, measured by LLR score. 3) Details of each GEO series dataset and its expression profile: Top panel shows the detailed information (e.g. title, summary) for the GEO series dataset. Bottom panel shows the background distribution and the expression profile for CEM genes in this dataset. Overview of Co-Expression Modules (CEMs) with Dataset Weighting Scale of average Pearson correlations Num of Genes in Query Geneset: 15. Num of CEMs: 1. 0.0 0.2 0.4 0.6 0.8 1.0 Atp2a1 Ryr1 Casq1 Tcap Mypn Cacna1s Ttn Ankrd23 Smtnl1 Aldoa Actc1 Myl3 Ankrd2 Ankrd1 Kat2b Atp2a1 Ryr1 Casq1 Tcap Mypn Cacna1s Ttn CEM 1 (158 datasets) Ankrd23 Smtnl1 Aldoa Actc1 Myl3 Ankrd2 Ankrd1 Singletons Kat2b Symbol Num ofCEMGenes:13.Predicted300.SelectedDatasets:158.Strength:15.7 CEM 1,Geneset"[G]Iband",Page1 Apobec2 Itgb1bp2 Cacna1s Ankrd23 Pde4dip Mybpc2 Cox6a2 Myom1 Ankrd2 Dhrs7c Ampd1 Smtnl1 Atp2a1 Trim54 Cmya5 Pgam2 Tmod4 Ckmt2 Klhl41 Casq1 Tnnc2 Actn2 Actn3 Aldoa Smpx Pygm Acta1 Actc1 Tnnt3 Pvalb Tpm2 Tnni2 Mylpf Mypn Myh2 Myh4 Rpl3l Eno3 Ldb3 Tcap Myot Nrap Myl1 Myl3 Ryr1 Hfe2 Ckm Neb Ttn Srl 0.0 1.0 GSE20152 [8] GSE22506 [12] GSE6210 [12] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE31431 [34] GSE41759 [14] GSE12730 [24] GSE20577 [12] GSE41997 [6] GSE50813 [24] GSE24243 [6] GSE49122 [14] GSE11990 [20] GSE32316 [12] GSE24207 [73] GSE38257 [14] GSE51628 [15] GSE4786 [9] GSE13563 [6] GSE25295 [25] GSE32422 [6] GSE19616 [16] GSE4866 [10] GSE27309 [10] GSE9954 [70] GSE52358 [8] GSE12248 [83] GSE22307 [23] GSE28389 [20] GSE19079 [6] GSE16992 [48] GSE6055 [8] GSE41342 [26] GSE5800 [6] GSE36826 [12] GSE19517 [6] GSE10246 [182] GSE3501 [6] GSE31004 [8] GSE43242 [10] GSE11186 [33] GSE12993 [6] GSE15772 [8] GSE51883 [30] GSE7863 [16] GSE16377 [6] GSE30688 [9] GSE17739 [24] GSE5657 [20] GSE17825 [18] GSE9330 [8] GSE8498 [6] GSE41907 [7] GSE13224 [6] GSE46209 [21] GSE31561 [36] GSE21716 [28] GSE39897 [36] GSE28457 [24] GSE43373 [130] GSE33308 [10] GSE16110 [16] GSE5861 [6] GSE38822 [22] GSE8733 [24] GSE18567 [24] GSE51686 [9] GSE37191 [12] GSE38048 [20] GSE30865 [68] GSE43779 [6] GSE16777 [38] GSE16496 [102] GSE13071 [15] GSE56236 [12] GSE28417 [12] GSE11343 [19] GSE13032 [18] GSE35357 [12] GSE20726 [9] GSE4694 [6] GSE9368 [12] GSE11291 [60] GSE23006 [48] GSE15155 [12] GSE6591 [15] GSE23724 [8] GSE27628 [34] GSE59437 [30] GSE23782 [18] GSE7694 [12] GSE7475 [16] GSE9725 [16] GSE32020 [26] GSE21247 [60] GSE6686 [13] GSE38693 [8] GSE8513 [10] GSE3313 [24] GSE43381 [26] GSE19204 [6] GSE9460 [26] GSE19793 [32] GSE6837 [8] GSE35206 [14] GSE5313 [6] GSE18341 [30] GSE35322 [20] GSE7381 [6] GSE8790 [22] GSE42299 [8] GSE54678 [6] GSE6482 [9] GSE13227 [6] GSE4768 [18] GSE22005 [23] GSE52597 [7] GSE10290 [24] GSE42473 [15] GSE50789 [96] GSE34765 [6] GSE22006 [19] GSE52474 [154] GSE24695 [9] GSE17513 [12] GSE38754 [40] GSE45968 [6] GSE35044 [9] GSE11035 [6] GSE39984 [18] GSE17462 [8] GSE4238 [24] GSE51417 [60] GSE5296 [96] GSE25908 [111] GSE3100 [23] GSE36833 [49] GSE10589 [6] GSE21263 [68] GSE4411 [11] GSE24920 [19] GSE44363 [16] GSE11981 [8] GSE14395 [24] GSE20398 [30] GSE6487 [30] GSE24873 [48] GSE3822 [16] GSE1806 [22] GSE14710 [12] GSE32937 [8] GSE33931 [42] GSE50122 [10] GSE12499 [10] GSE40087 [15] CEM+ CEM GSE4671 [28] GSE19657 [21] GSE8044 [6] GSE43635 [9] GSE20604 [6] GSE17649 [36] 0.0 GSE27630 [8] GSE24512 [29] GSE28031 [6] Scale ofaveragePearsoncorrelations GSE51927 [59] GSE9743 [12] GSE13421 [8] GSE29685 [132] GSE49128 [17] GSE37975 [8] 0.2 GSE9400 [8] GSE42049 [8] GSE22989 [10] GSE31570 [6] GSE40261 [8] GSE11804 [12] GSE33770 [8] GSE10813 [12] GSE55733 [24] 0.4 GSE10192 [24] GSE17797 [19] GSE19668 [50] GSE30138 [51] GSE7302 [6] GSE18993 [13] GSE20325 [6] GSE27987 [31] GSE8349 [10] 0.6 GSE13103 [8] GSE25911 [26] GSE8660 [6] GSE42008 [6] GSE19925 [6] GSE30192 [6] GSE27675 [14] GSE12948 [9] GSE43899 [12] 0.8 GSE8025 [21] GSE8407 [17] GSE17709 [18] GSE5891 [6] Score 437.90 440.22 440.75 449.70 454.02 472.55 475.02 482.42 489.78 493.65 500.49 509.86 514.33 523.48 527.70 529.59 538.74 538.77 539.72 561.75 563.50 574.60 575.40 612.85 620.89 629.92 630.30 634.59 636.51 636.97 660.85 669.01 701.47 729.65 741.63 778.45 780.71 1.0 Notes 2310002L09Rik Symbol Num ofCEMGenes:13.Predicted300.SelectedDatasets:158.Strength:15.7 CEM 1,Geneset"[G]Iband",Page2 Tmem182 Tmem38a Ppp1r27 Mybpc1 Cacng1 Cox7a1 Sh3bgr Pdlim7 Pdlim3 Adssl1 Trim63 Lmod2 Lmod3 Eef1a2 Obscn Myoz3 Hspb3 Hspb6 Cox8b Myoz2 Asb15 Scn4b Asb11 Klhl40 Tnnc1 Fabp3 Csrp3 Mylk4 Alpk3 Tnnt1 Jsrp1 Stac3 Fitm1 Txlnb Cap2 Asb2 Asb5 Pfkm Sgca Vgll2 Cav3 Murc Abra Myf6 Myl2 Rtn2 Mlf1 Des Hrc 0.0 1.0 GSE20152 [8] GSE22506 [12] GSE6210 [12] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE31431 [34] GSE41759 [14] GSE12730 [24] GSE20577 [12] GSE41997 [6] GSE50813 [24] GSE24243 [6] GSE49122 [14] GSE11990 [20] GSE32316 [12] GSE24207 [73] GSE38257 [14] GSE51628 [15] GSE4786 [9] GSE13563 [6] GSE25295 [25] GSE32422 [6] GSE19616 [16] GSE4866 [10] GSE27309 [10] GSE9954 [70] GSE52358 [8] GSE12248 [83] GSE22307 [23] GSE28389 [20] GSE19079 [6] GSE16992 [48] GSE6055 [8] GSE41342 [26] GSE5800 [6] GSE36826 [12] GSE19517 [6] GSE10246 [182] GSE3501 [6] GSE31004 [8] GSE43242 [10] GSE11186 [33] GSE12993 [6] GSE15772 [8] GSE51883 [30] GSE7863 [16] GSE16377 [6] GSE30688 [9] GSE17739 [24] GSE5657 [20] GSE17825 [18] GSE9330 [8] GSE8498 [6] GSE41907 [7] GSE13224 [6] GSE46209 [21] GSE31561 [36] GSE21716 [28] GSE39897 [36] GSE28457 [24] GSE43373 [130] GSE33308 [10] GSE16110 [16] GSE5861 [6] GSE38822 [22] GSE8733 [24] GSE18567 [24] GSE51686 [9] GSE37191 [12] GSE38048 [20] GSE30865 [68] GSE43779 [6] GSE16777 [38] GSE16496 [102] GSE13071 [15] GSE56236 [12] GSE28417 [12] GSE11343 [19] GSE13032 [18] GSE35357 [12] GSE20726 [9] GSE4694 [6] GSE9368 [12] GSE11291 [60] GSE23006 [48] GSE15155 [12] GSE6591 [15] GSE23724 [8] GSE27628 [34] GSE59437 [30] GSE23782 [18] GSE7694 [12] GSE7475 [16] GSE9725 [16] GSE32020 [26] GSE21247 [60] GSE6686 [13] GSE38693 [8] GSE8513 [10] GSE3313 [24] GSE43381 [26] GSE19204 [6] GSE9460 [26] GSE19793 [32] GSE6837 [8] GSE35206 [14] GSE5313 [6] GSE18341 [30] GSE35322 [20] GSE7381 [6] GSE8790 [22] GSE42299 [8] GSE54678 [6] GSE6482 [9] GSE13227 [6] GSE4768 [18] GSE22005 [23] GSE52597 [7] GSE10290 [24] GSE42473 [15] GSE50789 [96] GSE34765 [6] GSE22006 [19] GSE52474 [154] GSE24695 [9] GSE17513 [12] GSE38754 [40] GSE45968 [6] GSE35044 [9] GSE11035 [6] GSE39984 [18] GSE17462 [8] GSE4238 [24] GSE51417 [60] GSE5296 [96] GSE25908 [111] GSE3100 [23] GSE36833 [49] GSE10589 [6] GSE21263 [68] GSE4411 [11] GSE24920 [19] GSE44363 [16] GSE11981 [8] GSE14395 [24] GSE20398 [30] GSE6487 [30] GSE24873 [48] GSE3822 [16] GSE1806 [22] GSE14710 [12] GSE32937 [8] GSE33931 [42] GSE50122 [10] GSE12499 [10] GSE40087 [15] CEM+ CEM GSE4671 [28] GSE19657 [21] GSE8044 [6] GSE43635 [9] GSE20604 [6] GSE17649 [36] 0.0 GSE27630 [8] GSE24512 [29] GSE28031 [6] Scale ofaveragePearsoncorrelations GSE51927 [59] GSE9743 [12] GSE13421 [8] GSE29685 [132] GSE49128 [17] GSE37975 [8] 0.2 GSE9400 [8] GSE42049 [8] GSE22989 [10] GSE31570 [6] GSE40261 [8] GSE11804 [12] GSE33770 [8] GSE10813 [12] GSE55733 [24] 0.4 GSE10192 [24] GSE17797 [19] GSE19668 [50] GSE30138 [51] GSE7302 [6] GSE18993 [13] GSE20325 [6] GSE27987 [31] GSE8349 [10] 0.6 GSE13103 [8] GSE25911 [26] GSE8660 [6] GSE42008 [6] GSE19925 [6] GSE30192 [6] GSE27675 [14] GSE12948 [9] GSE43899 [12] 0.8 GSE8025 [21] GSE8407 [17] GSE17709 [18] GSE5891 [6] Score 217.37 220.49 222.51 228.96 232.88 238.63 239.24 241.29 242.76 250.48 252.51 254.34 254.40 255.44 257.51 262.30 263.35 266.86 274.12 277.34 284.81 286.51 287.14 289.90 291.56 292.27 294.33 298.73 300.59 309.74 311.74 318.32 319.15 327.15 331.89 350.12 363.50 390.06 391.78 397.20 398.40 405.65 405.87 408.42 415.88 420.70 421.96 424.24 424.96 437.74 1.0 Notes Symbol Num ofCEMGenes:13.Predicted300.SelectedDatasets:158.Strength:15.7 CEM 1,Geneset"[G]Iband",Page3 Macrod1 Synpo2l Mapk12 Popdc3 Unc45b Dusp27 Dusp13 Myom3 Prkag3 Smtnl2 Tmod1 Mybph Slc2a4 Tceal7 Perm1 Hspb2 Myoz1 Hspb7 Capn3 Asb10 Adck3 Asb12 Klhl30 Phkg1 Asb14 Phka1 Tbx15 Coro6 Tcea3 Mef2c Mylk2 Ctxn3 Ddit4l Alpk2 Tnni1 Tpm3 Myh7 Myh8 Lrrc2 Xirp1 Hhatl Yipf7 Sgcg Nexn Fsd2 Pkia Flnc Fhl1 Mlip Agl 0.0 1.0 GSE20152 [8] GSE22506 [12] GSE6210 [12] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE31431 [34] GSE41759 [14] GSE12730 [24] GSE20577 [12] GSE41997 [6] GSE50813 [24] GSE24243 [6] GSE49122 [14] GSE11990 [20] GSE32316 [12] GSE24207 [73] GSE38257 [14] GSE51628 [15] GSE4786 [9] GSE13563 [6] GSE25295 [25] GSE32422 [6] GSE19616 [16] GSE4866 [10] GSE27309

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